Vitamin E 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3613	1406-18-4

Description:

Molecule	Description
Synonyms: tocopherol (vit E) Vitamin E Tocofer 400	A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

tocopherol (vit E)
Vitamin E
Tocofer 400

A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
0.20	g	O
0.20	g	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA03	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:22587	antiviral agents
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:37700	protein kinase C inhibitors
CHEBI has role	CHEBI:50249	anticoagulants
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:50846	Immunologic factor
CHEBI has role	CHEBI:50855	antiatherogenic drug
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:84735	algal metabolites
CHEBI has role	CHEBI:24020	fat-soluble vitamins
MeSH PA	D000975	Antioxidants
MeSH PA	D018977	Micronutrients
MeSH PA	D020011	Protective Agents
MeSH PA	D014815	Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vitamin E deficiency	indication	54137008

🐶 Veterinary Drug Use

Species	Use	Relation
Cattle	Prevention and treatment of selenium-tocopherol deficiency syndrome	Indication
Sheep	Prevention and treatment of selenium-tocopherol deficiency syndrome	Indication
Swine	Diseases associated with Selenium-Tocopherol deficiency	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
BO-SE	Intervet Inc.	2
Seletoc Minicaps and Caps	Intervet Inc.	2
Mu-Se	Intervet Inc.	2
E-SE	Intervet Inc.	2
Seletoc Injection	Intervet Inc.	2
Velenium	Zoetis Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glutathione S-transferase P	Enzyme	P09211	GSTP1_HUMAN		IC50	6.30		CHEMBL
Alpha-tocopherol transfer protein	Transporter	P49638	TTPA_HUMAN		Kd	5.62		CHEMBL

External reference:

ID	Source
4017656	VUID
N0000146035	NUI
D02331	KEGG_DRUG
4017656	VANDF
4021718	VANDF
C0042874	UMLSCUI
CHEBI:33229	CHEBI
VIT	PDB_CHEM_ID
CHEMBL3989727	ChEMBL_ID
CHEMBL47	ChEMBL_ID
D014810	MESH_DESCRIPTOR_UI
DB00163	DRUGBANK_ID
14985	PUBCHEM_CID
11256	RXNORM
37013	MMSL
5201	MMSL
5689	MMSL
d00405	MMSL
37237003	SNOMEDCT_US
63822004	SNOMEDCT_US

Pharmaceutical products:

None