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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tiazofurine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
3605
60084-10-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tiazofurin
riboxamide
tiazofurine
Molecular weight: 260.26
Formula: C9H12N2O5S
CLOGP: -1.86
LIPINSKI: 0
HAC: 7
HDO: 4
TPSA: 125.90
ALOGS: -1.65
ROTB: 3
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
5.90 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
2.40 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
1.10 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.47 %
Lombardo F, Berellini G, Obach RS
Showing 1 to 4 of 4 entries
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L01XX18
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:50266
Prodrugs
CHEBI has role
CHEBI:53746
EC 1.1.1.205 inhibitor
MeSH PA
D000963
Antimetabolites
MeSH PA
D000964
Antimetabolites, Antineoplastic
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D009676
Noxae
Showing 1 to 8 of 8 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.54
acidic
pKa2
13.16
acidic
pKa3
13.51
acidic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
TIZ
PDB_CHEM_ID
457954
PUBCHEM_CID
5220
INN_ID
C033706
MESH_SUPPLEMENTAL_RECORD_UI
C3652605
UMLSCUI
CHEBI:90239
CHEBI
CHEMBL108358
ChEMBL_ID
D06130
KEGG_DRUG
DB13243
DRUGBANK_ID
ULJ82834RE
UNII
Showing 1 to 10 of 10 entries
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Pharmaceutical products:
None
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tiazofurine