All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

tetryzoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihistaminics or local vasoconstrictors, antazoline derivatives	3591	84-22-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: tetrahydrozoline nitrate tetrahydrozoline (+/-)-Tetrahydrozoline ocuzolin tetryzolin tetryzoline dl-Tetrahydrozoline tetrahydrozoline hydrochloride tetrahydrozeline hydrochloride tetrahydrozeline nitrate tetrahydrozoline HCl tetrahydrozeline HCl	used as nasal decongestant; Visine is a form of eye drops; RN given refers to parent cpd; structure Molecular weight: 200.29 Formula: C13H16N2 CLOGP: 3.54 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 24.39 ALOGS: -2.92 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.80	mg	N

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Nov. 30, 1979	FDA	FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R01AA06	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain
ATC	R01AB03	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, combinations excl. corticosteroids
ATC	S01GA02	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
ATC	S01GA52	SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014663	Nasal Decongestants
MeSH PA	D009883	Ophthalmic Solutions
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019999	Pharmaceutical Solutions
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D013566	Sympathomimetics
MeSH PA	D014662	Vasoconstrictor Agents
CHEBI has role	CHEBI:35524	sympathomimetic
CHEBI has role	CHEBI:77715	nasal decongestants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Red eye	indication	75705005
Hyperthyroidism	contraindication	34486009	DOID:7998
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Diabetes mellitus	contraindication	73211009	DOID:9351

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.93	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adrenergic receptor alpha	GPCR	P08913 P18089 P18825 P25100 P35348 P35368	ADA2A_HUMAN ADA2B_HUMAN ADA2C_HUMAN ADA1D_HUMAN ADA1A_HUMAN ADA1B_HUMAN	AGONIST				CHEMBL	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	7.52		CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		IC50	5.80		CHEMBL
Adrenergic receptor alpha	GPCR		ADA1B_RAT ADA2B_RAT ADA2C_RAT ADA2A_RAT ADA1D_RAT ADA1A_RAT		Ki	7.96		CHEMBL

External reference:

ID	Source
4022735	VUID
N0000020740	NUI
D00756	KEGG_DRUG
118201-38-0	SECONDARY_CAS_RN
522-48-5	SECONDARY_CAS_RN
4018994	VANDF
4022735	VANDF
C0076286	UMLSCUI
CHEBI:28674	CHEBI
CHEMBL1200413	ChEMBL_ID
CHEMBL1266	ChEMBL_ID
DB06764	DRUGBANK_ID
C005810	MESH_SUPPLEMENTAL_RECORD_UI
5419	PUBCHEM_CID
37935	RXNORM
5562	MMSL
72350	MMSL
7784	MMSL
001803	NDDF
004726	NDDF
2183004	SNOMEDCT_US
372673004	SNOMEDCT_US
50969006	SNOMEDCT_US
519	INN_ID
8P9X484T3F	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Glitch Advanced Relief Eye Drops	HUMAN OTC DRUG LABEL	2	0276-0801	SOLUTION/ DROPS	0.05 g	OPHTHALMIC	OTC monograph final	14 sections
Walgreens Multi-Symptom Relief Eye Drops	HUMAN OTC DRUG LABEL	5	0363-1462	SOLUTION/ DROPS	0.05 g	OPHTHALMIC	OTC monograph final	13 sections
Walgreens Sterile Original Eye Drops	HUMAN OTC DRUG LABEL	1	0363-1676	SOLUTION/ DROPS	0.05 mg	OPHTHALMIC	OTC monograph final	12 sections
Walgreens Sterile Advance Relief Eye Drops	HUMAN OTC DRUG LABEL	4	0363-1677	SOLUTION/ DROPS	0.00 mg	OPHTHALMIC	OTC monograph final	12 sections
Walgreens Eye Drops Seasonal Relief 15mL	HUMAN OTC DRUG LABEL	2	0363-4545	LIQUID	0.05 g	OPHTHALMIC	OTC monograph final	14 sections
Walgreens Eye Drops Advanced Relief 15mL	HUMAN OTC DRUG LABEL	4	0363-4547	LIQUID	0.05 g	OPHTHALMIC	OTC monograph final	12 sections
Walgreens Eye Drops Original 15mL and twin pack	HUMAN OTC DRUG LABEL	1	0363-4550	LIQUID	0.05 g	OPHTHALMIC	OTC monograph final	13 sections
Walgreens Sterile Original Eye	HUMAN OTC DRUG LABEL	1	0363-7298	SOLUTION/ DROPS	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
Eye Drops	HUMAN OTC DRUG LABEL	1	0498-0161	SOLUTION/ DROPS	0.05 g	OPHTHALMIC	OTC monograph final	14 sections
Industrial Strength Eye Drops	HUMAN OTC DRUG LABEL	2	0498-0162	SOLUTION/ DROPS	0.05 g	OPHTHALMIC	OTC monograph final	15 sections
Rugby Tetrahydrozoline Ophthalmic Solution	HUMAN OTC DRUG LABEL	1	0536-1217	SOLUTION/ DROPS	0.05 g	OPHTHALMIC	OTC monograph final	14 sections
RohtoIce	HUMAN OTC DRUG LABEL	3	10742-8143	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
RohtoIce	HUMAN OTC DRUG LABEL	3	10742-8143	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
RohtoAll-In-One	HUMAN OTC DRUG LABEL	3	10742-8146	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
RohtoAll-In-One	HUMAN OTC DRUG LABEL	3	10742-8146	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
Rohto Digi-Eye	HUMAN OTC DRUG LABEL	2	10742-8175	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
Rohto Digi-Eye	HUMAN OTC DRUG LABEL	2	10742-8175	LIQUID	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
Up and Up Ultra Itchy Relief	HUMAN OTC DRUG LABEL	2	11673-672	SOLUTION/ DROPS	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
GOODSENSE ORIGINAL EYE DROPS	HUMAN OTC DRUG LABEL	1	11716-0002	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
GOODSENSE IRRITATION RELIEF EYE	HUMAN OTC DRUG LABEL	2	11716-0003	SOLUTION/ DROPS	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
GOODSENSE ADVANCED RELIEF EYE	HUMAN OTC DRUG LABEL	4	11716-0004	SOLUTION/ DROPS	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
DG HEALTH ORIGINAL	HUMAN OTC DRUG LABEL	1	11716-0053	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	22 sections
PREMIER VALUE ORIGINAL	HUMAN OTC DRUG LABEL	1	11716-0101	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	12 sections
PREMIER VALUE ADVANCED EYE DROPS	HUMAN OTC DRUG LABEL	4	11716-0102	SOLUTION	0.00 mL	OPHTHALMIC	OTC monograph final	22 sections
PREMIER VALUE EYE AC	HUMAN OTC DRUG LABEL	2	11716-0103	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
SHOPKO ADVANCED FORMULA EYE DROPS	HUMAN OTC DRUG LABEL	4	11716-0458	SOLUTION	0.00 mL	OPHTHALMIC	OTC monograph final	22 sections
SHOPKO RELIEF	HUMAN OTC DRUG LABEL	2	11716-0460	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	11 sections
LEADER ADVANCED FORMULA EYE DROPS	HUMAN OTC DRUG LABEL	4	11716-1104	SOLUTION	0.00 mL	OPHTHALMIC	OTC monograph final	22 sections
WALGREENS MAXIMUM RELIEF EYE DROPS	HUMAN OTC DRUG LABEL	4	11716-1167	SOLUTION	0.00 mL	OPHTHALMIC	OTC monograph final	22 sections
WALGREENS ORIGINAL EYE DROPS	HUMAN OTC DRUG LABEL	1	11716-1168	SOLUTION	0.50 mg	OPHTHALMIC	OTC monograph final	22 sections