bethanechol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 358 | 674-38-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, HEART RATE changes, and BRONCHIAL SPASM.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 45 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 14.53 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 12, 1948 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Peritonitis | 81.92 | 64.50 | 12 | 26 | 2562 | 2355485 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N07AB02 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS PARASYMPATHOMIMETICS Choline esters |
| FDA EPC | N0000175840 | Cholinergic Muscarinic Agonist |
| FDA MoA | N0000000104 | Cholinergic Muscarinic Agonists |
| CHEBI has role | CHEBI:38325 | muscarinic agonist |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018679 | Cholinergic Agonists |
| MeSH PA | D018721 | Muscarinic Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D010277 | Parasympathomimetics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Retention of urine | indication | 267064002 | |
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Irritable bowel syndrome | contraindication | 10743008 | DOID:9778 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Increased gastric tonus | contraindication | 18644006 | |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Orthostatic hypotension | contraindication | 28651003 | |
| Parkinsonism | contraindication | 32798002 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Low blood pressure | contraindication | 45007003 | |
| Peritonitis | contraindication | 48661000 | |
| Bradycardia | contraindication | 48867003 | |
| Parkinson's disease | contraindication | 49049000 | DOID:14330 |
| Abnormal vasomotor function | contraindication | 70670009 | |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Atrioventricular block | contraindication | 233917008 | DOID:0050820 |
| Anastomosis of intestine | contraindication | 235407009 | |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Bladder Surgery | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | AGONIST | Ki | 4.20 | IUPHAR | CHEMBL | |||
| Muscarinic acetylcholine receptor M2 | GPCR | AGONIST | Ki | 4 | IUPHAR | CHEMBL | |||
| Muscarinic acetylcholine receptor M4 | GPCR | AGONIST | Ki | 4 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M1 | GPCR | AGONIST | Ki | 4 | IUPHAR | ||||
| Muscarinic acetylcholine receptor | GPCR | Kd | 4.90 | CHEMBL | |||||
| Muscarinic receptor 2 | Unclassified | EC50 | 6 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019634 | VUID |
| N0000147727 | NUI |
| C0053526 | UMLSCUI |
| D01000 | KEGG_DRUG |
| 31690003 | SNOMEDCT_US |
| 4019634 | VANDF |
| 19257 | RXNORM |
| 372698003 | SNOMEDCT_US |
| d01427 | MMSL |
| 004683 | NDDF |
| 2370 | PUBCHEM_CID |
| CHEBI:3084 | CHEBI |
| CHEMBL1482 | ChEMBL_ID |
| DB01019 | DRUGBANK_ID |
| CHEMBL1768 | ChEMBL_ID |
| H4QBZ2LO84 | UNII |
| 590-63-6 | SECONDARY_CAS_RN |
| 297 | IUPHAR_LIGAND_ID |
| D018723 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1329 | TABLET | 50 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1332 | TABLET | 5 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1340 | TABLET | 10 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1356 | TABLET | 25 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2557 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-2558 | TABLET | 25 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7912 | TABLET | 25 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0510 | TABLET | 5 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0511 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0512 | TABLET | 25 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-0513 | TABLET | 50 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6178 | TABLET | 25 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-516 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-517 | TABLET | 25 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-518 | TABLET | 50 mg | ORAL | ANDA | 11 sections |
| bethanechol chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 23155-679 | TABLET | 50 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50111-323 | TABLET | 5 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50111-324 | TABLET | 10 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50111-325 | TABLET | 25 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50111-326 | TABLET | 50 mg | ORAL | ANDA | 10 sections |
| Urecholine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51285-690 | TABLET | 10 mg | ORAL | ANDA | 10 sections |
| Urecholine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51285-691 | TABLET | 25 mg | ORAL | ANDA | 10 sections |
| Urecholine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51285-692 | TABLET | 50 mg | ORAL | ANDA | 10 sections |
| Urecholine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51285-697 | TABLET | 5 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-645 | TABLET | 5 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-646 | TABLET | 10 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-647 | TABLET | 25 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51293-648 | TABLET | 50 mg | ORAL | ANDA | 10 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-1624 | TABLET | 10 mg | ORAL | ANDA | 11 sections |
| Bethanechol Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-1625 | TABLET | 25 mg | ORAL | ANDA | 11 sections |