sodium tetradecyl sulfate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3550 139-88-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • TETRADECYL HYDROGEN SULFATE (ESTER)
  • tetradecyl sulfate
  • sodium tetradecyl sulfate
  • sodium sotradecol
  • sotradecol
  • tetradecyl sulfuric acid
An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins.
  • Molecular weight: 294.45
  • Formula: C14H30O4S
  • CLOGP: 5.57
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 1
  • TPSA: 63.60
  • ALOGS: -4.45
  • ROTB: 11

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1946 FDA ELKINS SINN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C05BB04 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
ANTIVARICOSE THERAPY
Sclerosing agents for local injection
MeSH PA D002317 Cardiovascular Agents
MeSH PA D019999 Pharmaceutical Solutions
MeSH PA D012597 Sclerosing Solutions
MeSH PA D013501 Surface-Active Agents
CHEBI has role CHEBI:27780 detergents
CHEBI has role CHEBI:63923 sclerotherapy agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Venous varices indication 128060009 DOID:799
Incompetence of any valvular structure contraindication 10337008
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Peripheral venous insufficiency contraindication 20696009 DOID:10128
Acute tuberculosis contraindication 25629007
Thrombophlebitis migrans contraindication 31268005 DOID:14392
Infectious disease contraindication 40733004
Thromboangiitis obliterans contraindication 52403007 DOID:12918
Thrombophlebitis contraindication 64156001 DOID:3875
Arteriosclerotic vascular disease contraindication 72092001
Thyrotoxicosis contraindication 90739004 DOID:7997
Neoplasm contraindication 108369006
Bed-ridden contraindication 160685001
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Sepsis syndrome contraindication 238150007
Diabetic - poor control contraindication 268519009
Exacerbation of asthma contraindication 281239006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.02 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D06882 KEGG_DRUG
300-52-7 SECONDARY_CAS_RN
4019068 VANDF
C0087006 UMLSCUI
CHEBI:75273 CHEBI
CHEMBL1200354 ChEMBL_ID
CHEMBL1201345 ChEMBL_ID
D012981 MESH_DESCRIPTOR_UI
130 INN_ID
DB00464 DRUGBANK_ID
DB11328 DRUGBANK_ID
Q1SUG5KBD6 UNII
23665772 PUBCHEM_CID
1370424 RXNORM
1154 MMSL
1445 MMSL
5497 MMSL
d01383 MMSL
002554 NDDF
387320008 SNOMEDCT_US
57616006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sodium Tetradecyl Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 24201-201 INJECTION, SOLUTION 30 mg INTRAVENOUS ANDA 19 sections
Sotradecol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4525 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
Sotradecol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4529 INJECTION, SOLUTION 30 mg INTRAVENOUS ANDA 20 sections
(SOTRADECOL) SODIUM TETRADECYL SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1563 INJECTION, SOLUTION 30 mg INTRAVENOUS ANDA 18 sections
Sotradecol HUMAN PRESCRIPTION DRUG LABEL 1 67457-162 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 20 sections
Sotradecol HUMAN PRESCRIPTION DRUG LABEL 1 67457-163 INJECTION, SOLUTION 30 mg INTRAVENOUS ANDA 20 sections