sitaxentan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
endothelin receptor antagonists 3548 210421-74-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thelin
  • sitaxentan
  • sitaxentan sodium
  • sitaxsentan
  • TBC11251
  • TBC-11251
endothelin A receptor antagonist
  • Molecular weight: 454.90
  • Formula: C18H15ClN2O6S2
  • CLOGP: 3.59
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 107.73
  • ALOGS: -4.40
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 10, 2006 EMA Pfizer Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C02KX03 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
OTHER ANTIHYPERTENSIVES
Antihypertensives for pulmonary arterial hypertension
MeSH PA D065128 Endothelin Receptor Antagonists

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pulmonary arterial hypertension indication 11399002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.66 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Endothelin-1 receptor GPCR ANTAGONIST Ki 9.37 CHEMBL IUPHAR
Endothelin B receptor GPCR ANTAGONIST IC50 5.01 CHEMBL
Endothelin-1 receptor GPCR ANTAGONIST Ki 9.37 CHEMBL

External reference:

IDSource
D07171 KEGG_DRUG
CHEBI:135736 CHEBI
CHEMBL282724 ChEMBL_ID
CHEMBL2105740 ChEMBL_ID
DB06268 DRUGBANK_ID
C106276 MESH_SUPPLEMENTAL_RECORD_UI
3950 IUPHAR_LIGAND_ID
7952 INN_ID
J9QH779MEM UNII
216235 PUBCHEM_CID
012019 NDDF
012042 NDDF
428709002 SNOMEDCT_US
428712004 SNOMEDCT_US
428790008 SNOMEDCT_US
C1704271 UMLSCUI
184036-34-8 SECONDARY_CAS_RN

Pharmaceutical products:

None