sabcomeline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
cholinergic agents (muscarine receptor agonists/partial antagonists used in the treatment of Alzheimer's disease)	3536	159912-53-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sabcomeline
sabcomeline hydrochloride
SB-202026-A
sabcomeline HCl

selective for M1 receptors; RN refers to (R,S)-isomer

Molecular weight: 193.25
Formula: C10H15N3O
CLOGP: 1.09
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 48.62
ALOGS: -1.27
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.82	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		IC50	6.77		CHEMBL
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		IC50	6.74		CHEMBL
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		IC50	7.22		CHEMBL
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		EC50	8.24		CHEMBL
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN	AGONIST	Ki	7.10		IUPHAR
Muscarinic acetylcholine receptor	GPCR		ACM1_RAT ACM3_RAT ACM4_RAT ACM5_RAT ACM2_RAT		IC50	7.85		CHEMBL

External reference:

ID	Source
D05779	KEGG_DRUG
159912-58-0	SECONDARY_CAS_RN
C0669113	UMLSCUI
CHEBI:134846	CHEBI
CHEMBL134641	ChEMBL_ID
9577995	PUBCHEM_CID
7427	INN_ID
C109640	MESH_SUPPLEMENTAL_RECORD_UI
306	IUPHAR_LIGAND_ID
P8P92V596C	UNII
CHEMBL2107146	ChEMBL_ID

Pharmaceutical products:

None