sabcomeline Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
cholinergic agents (muscarine receptor agonists/partial antagonists used in the treatment of Alzheimer's disease) 3536 159912-53-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sabcomeline
  • sabcomeline hydrochloride
  • SB-202026-A
  • sabcomeline HCl
selective for M1 receptors; RN refers to (R,S)-isomer
  • Molecular weight: 193.25
  • Formula: C10H15N3O
  • CLOGP: 1.09
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 48.62
  • ALOGS: -1.27
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M5 GPCR AGONIST Ki 7.10 IUPHAR
Muscarinic acetylcholine receptor M3 GPCR IC50 7.22 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR EC50 8.24 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR IC50 6.74 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR IC50 6.77 CHEMBL
Muscarinic acetylcholine receptor GPCR IC50 7.85 CHEMBL

External reference:

IDSource
D05779 KEGG_DRUG
A24BK93DRR UNII
159912-58-0 SECONDARY_CAS_RN
9577995 PUBCHEM_CID
CHEBI:134846 CHEBI
CHEMBL134641 ChEMBL_ID
7427 INN_ID
C109640 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2107146 ChEMBL_ID
306 IUPHAR_LIGAND_ID

Pharmaceutical products:

None