rapacuronium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| neuromuscular blocking agents with rigid structure | 3520 | 156137-99-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a nondepolarizing neuromuscular blocking agent with a rapid onset of action acts by competing for cholinergic receptors at the motor end plate
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 18, 1999 | FDA | ORGANON USA INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D009466 | Neuromuscular Blocking Agents |
| MeSH PA | D003473 | Neuromuscular Nondepolarizing Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Muscle relaxation, function | indication | 11977004 | |
| General anesthesia | indication | 50697003 | |
| Skeletal Muscle Relaxation for Endotracheal Intubation | indication | ||
| Skeletal Muscle Relaxation for Endotracheal Intubation in C-Section | indication | ||
| Eaton-Lambert syndrome | contraindication | 56989000 | DOID:0050214 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscle-type nicotinic acetylcholine receptor | Ion channel | ANTAGONIST | CHEMBL | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 4021207 | VUID |
| N0000148653 | NUI |
| D05703 | KEGG_DRUG |
| 4021206 | VANDF |
| 4021207 | VANDF |
| CHEBI:135845 | CHEBI |
| CHEMBL1201352 | ChEMBL_ID |
| CHEMBL1200549 | ChEMBL_ID |
| C082938 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB04834 | DRUGBANK_ID |
| GG1LBM463S | UNII |
| 228530 | RXNORM |
| 31315 | MMSL |
| 8291 | MMSL |
| d04450 | MMSL |
| 007881 | NDDF |
| 013422 | NDDF |
| 116106006 | SNOMEDCT_US |
| 763001001 | SNOMEDCT_US |
| 764600006 | SNOMEDCT_US |
| C0876716 | UMLSCUI |
| 7635 | INN_ID |
| 5311399 | PUBCHEM_CID |
| 465499-11-0 | SECONDARY_CAS_RN |
Pharmaceutical products:
None