pyridoxal phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3506	54-47-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pyridoxal 5-phosphate codecarboxylase coenzyme B6 phosphopyridoxal phosphopyridoxal coenzyme pyridoxal 5-monophosphoric acid ester pyridoxal monophosphate pyridoxaldehyde phosphate pyridoxyl phosphate Vitamin B6 phosphate Vitamin B6 (Active form) pyridoxal phosphate	This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). Molecular weight: 247.14 Formula: C8H10NO6P CLOGP: -0.57 LIPINSKI: 0 HAC: 7 HDO: 3 TPSA: 116.95 ALOGS: -1.64 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pyridoxal 5-phosphate
codecarboxylase
coenzyme B6
phosphopyridoxal
phosphopyridoxal coenzyme
pyridoxal 5-monophosphoric acid ester
pyridoxal monophosphate
pyridoxaldehyde phosphate
pyridoxyl phosphate
Vitamin B6 phosphate
Vitamin B6 (Active form)
pyridoxal phosphate

This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).

Molecular weight: 247.14
Formula: C8H10NO6P
CLOGP: -0.57
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 116.95
ALOGS: -1.64
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11HA06	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
MeSH PA	D018977	Micronutrients
MeSH PA	D014803	Vitamin B Complex
MeSH PA	D014815	Vitamins
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:23354	coenzymes
CHEBI has role	CHEBI:131699	EC 2.7.7.7 inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.56	acidic
pKa2	6.61	acidic
pKa3	8.45	acidic
pKa4	3.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
P2X purinoceptor 1	Ion channel	P51575	P2RX1_HUMAN		IC50	5		CHEMBL
Low molecular weight phosphotyrosine protein phosphatase	Enzyme	P24666	PPAC_HUMAN		Ki	4.89		CHEMBL

External reference:

ID	Source
4024929	VUID
N0000023490	NUI
41468-25-1	SECONDARY_CAS_RN
4024929	VANDF
CHEBI:18405	CHEBI
CHEBI:17310	CHEBI
PLP	PDB_CHEM_ID
PXL	PDB_CHEM_ID
CHEMBL82202	ChEMBL_ID
CHEMBL3181870	ChEMBL_ID
5249	IUPHAR_LIGAND_ID
DB00114	DRUGBANK_ID
5V5IOJ8338	UNII
9002	RXNORM
227241	MMSL
30462	MMSL
327587	MMSL
003448	NDDF
019440	NDDF
259663004	SNOMEDCT_US
430926008	SNOMEDCT_US
770955002	SNOMEDCT_US
C0034266	UMLSCUI
D011732	MESH_DESCRIPTOR_UI
C0034263	UMLSCUI
DB00147	DRUGBANK_ID
1051	PUBCHEM_CID
66-72-8	SECONDARY_CAS_RN
D011730	MESH_DESCRIPTOR_UI
1050	PUBCHEM_CID

Pharmaceutical products:

None