pyridoxal phosphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3506 54-47-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxal 5-phosphate
  • codecarboxylase
  • coenzyme B6
  • phosphopyridoxal
  • phosphopyridoxal coenzyme
  • pyridoxal 5-monophosphoric acid ester
  • pyridoxal monophosphate
  • pyridoxaldehyde phosphate
  • pyridoxyl phosphate
  • Vitamin B6 phosphate
  • Vitamin B6 (Active form)
  • pyridoxal phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
  • Molecular weight: 247.14
  • Formula: C8H10NO6P
  • CLOGP: -0.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 116.95
  • ALOGS: -1.64
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 35.21 0 9 7 101615 2256454

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC A11HA06 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.56 acidic
pKa2 6.61 acidic
pKa3 8.45 acidic
pKa4 3.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2X purinoceptor 1 Ion channel IC50 5 CHEMBL

External reference:

IDSource
4024929 VUID
N0000023490 NUI
C0034266 UMLSCUI
5V5IOJ8338 UNII
41468-25-1 SECONDARY_CAS_RN
4024929 VANDF
259663004 SNOMEDCT_US
9004 RXNORM
003448 NDDF
227241 MMSL
30462 MMSL
1051 PUBCHEM_CID
CHEBI:18405 CHEBI
CHEMBL82202 ChEMBL_ID
DB00114 DRUGBANK_ID
PLP PDB_CHEM_ID
D011732 MESH_DESCRIPTOR_UI
CHEMBL3181870 ChEMBL_ID
5249 IUPHAR_LIGAND_ID
DB00147 DRUGBANK_ID

Pharmaceutical products:

None