protoporphyrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3500	553-12-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

Protoporphyrin IX
protoporphyrin
protoporphyrinprotoporphyrin disodium

Molecular weight: 562.67
Formula: C34H34N4O4
CLOGP: 8.36
LIPINSKI: 2
HAC: 8
HDO: 4
TPSA: 131.96
ALOGS: -4.40
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D017319	Photosensitizing Agents
MeSH PA	D011838	Radiation-Sensitizing Agents
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:47868	photosensitising agent
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.14	acidic
pKa2	3.76	acidic
pKa3	12.6	acidic
pKa4	9.42	Basic
pKa5	5.16	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Zinc finger protein mex-5	Cytosolic other		MEX5_CAEEL		EC50	5.05		CHEMBL
Cytoplasmic zinc-finger protein	Unclassified		G5EF15_CAEEL		EC50	5		CHEMBL

External reference:

ID	Source
C0033733	UMLSCUI
CHEBI:15430	CHEBI
PP9	PDB_CHEM_ID
CHEMBL267548	ChEMBL_ID
CHEMBL1325592	ChEMBL_ID
CHEMBL1907972	ChEMBL_ID
DB02285	DRUGBANK_ID
C028025	MESH_SUPPLEMENTAL_RECORD_UI
C2K325S808	UNII
4971	PUBCHEM_CID
006951	NDDF
51866008	SNOMEDCT_US
80918003	SNOMEDCT_US

Pharmaceutical products:

None