propoxycaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 3496 | 86-43-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1017)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | EASTMAN KODAK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.8 | Basic |
| pKa2 | 2.55 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | BLOCKER | IC50 | 4.62 | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02099 | KEGG_DRUG |
| 550-83-4 | SECONDARY_CAS_RN |
| C0033492 | UMLSCUI |
| CHEBI:8496 | CHEBI |
| CHEMBL1195 | ChEMBL_ID |
| CHEMBL1769 | ChEMBL_ID |
| DB09342 | DRUGBANK_ID |
| D011430 | MESH_DESCRIPTOR_UI |
| 6843 | PUBCHEM_CID |
| 319 | INN_ID |
| EPD1EH7F53 | UNII |
| 001357 | NDDF |
| 004570 | NDDF |
| 387454005 | SNOMEDCT_US |
| 78936006 | SNOMEDCT_US |
| 79221007 | SNOMEDCT_US |
Pharmaceutical products:
None