Stem definition | Drug id | CAS RN |
---|---|---|
prednisone and prednisolone derivatives | 348 | 378-44-9 |
Dose | Unit | Route |
---|---|---|
1.50 | mg | O |
1.50 | mg | P |
0.40 | mg | P |
0.40 | mg | N |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.06 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 4.80 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.38 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.36 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5.60 hours | Lombardo F, Berellini G, Obach RS |
BA (Bioavailability) | 0.72 % | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Date | Agency | Company | Orphan |
---|---|---|---|
April 17, 1961 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature delivery | 1980.90 | 13.98 | 614 | 18775 | 29667 | 63439966 |
Premature baby | 1128.54 | 13.98 | 366 | 19023 | 20369 | 63449264 |
Maternal exposure during pregnancy | 1065.84 | 13.98 | 720 | 18669 | 219342 | 63250291 |
Low birth weight baby | 757.39 | 13.98 | 211 | 19178 | 6918 | 63462715 |
Exposure during pregnancy | 668.64 | 13.98 | 474 | 18915 | 155073 | 63314560 |
Foetal exposure during pregnancy | 647.94 | 13.98 | 273 | 19116 | 31689 | 63437944 |
Normal labour | 393.73 | 13.98 | 76 | 19313 | 441 | 63469192 |
Delivery | 349.45 | 13.98 | 82 | 19307 | 1321 | 63468312 |
Macular degeneration | 299.45 | 13.98 | 147 | 19242 | 24229 | 63445404 |
Product use in unapproved indication | 263.46 | 13.98 | 298 | 19091 | 178782 | 63290851 |
Neonatal respiratory distress syndrome | 217.06 | 13.98 | 65 | 19324 | 2753 | 63466880 |
Premature labour | 204.75 | 13.98 | 92 | 19297 | 12412 | 63457221 |
Foetal growth restriction | 181.63 | 13.98 | 73 | 19316 | 7480 | 63462153 |
Computerised tomogram thorax abnormal | 177.16 | 13.98 | 50 | 19339 | 1713 | 63467920 |
Patent ductus arteriosus | 141.27 | 13.98 | 52 | 19337 | 4198 | 63465435 |
Pre-eclampsia | 130.07 | 13.98 | 61 | 19328 | 9072 | 63460561 |
Computerised tomogram thorax | 121.09 | 13.98 | 28 | 19361 | 421 | 63469212 |
Live birth | 106.99 | 13.98 | 77 | 19312 | 25553 | 63444080 |
Psoriasis | 101.72 | 13.98 | 129 | 19260 | 86828 | 63382805 |
Steroid withdrawal syndrome | 100.48 | 13.98 | 25 | 19364 | 520 | 63469113 |
Atelectasis | 93.02 | 13.98 | 66 | 19323 | 21417 | 63448216 |
Normal newborn | 92.61 | 13.98 | 47 | 19342 | 8294 | 63461339 |
Premature rupture of membranes | 92.24 | 13.98 | 40 | 19349 | 4953 | 63464680 |
Caesarean section | 92.00 | 13.98 | 60 | 19329 | 16972 | 63452661 |
Ductus arteriosus premature closure | 80.32 | 13.98 | 19 | 19370 | 317 | 63469316 |
Respiratory disorder neonatal | 75.88 | 13.98 | 24 | 19365 | 1221 | 63468412 |
Skin exfoliation | 75.85 | 13.98 | 79 | 19310 | 43023 | 63426610 |
Gestational diabetes | 72.49 | 13.98 | 40 | 19349 | 8356 | 63461277 |
Selective eating disorder | 71.26 | 13.98 | 26 | 19363 | 2046 | 63467587 |
Oligohydramnios | 71.05 | 13.98 | 36 | 19353 | 6330 | 63463303 |
Preterm premature rupture of membranes | 68.96 | 13.98 | 23 | 19366 | 1386 | 63468247 |
Hypoxia | 65.65 | 13.98 | 86 | 19303 | 59706 | 63409927 |
Drug ineffective | 63.95 | 13.98 | 539 | 18850 | 1044226 | 62425407 |
Chronic sinusitis | 61.54 | 13.98 | 42 | 19347 | 12801 | 63456832 |
Bradycardia neonatal | 60.72 | 13.98 | 19 | 19370 | 933 | 63468700 |
Foetal hypokinesia | 53.39 | 13.98 | 15 | 19374 | 505 | 63469128 |
Neonatal hypocalcaemia | 52.44 | 13.98 | 9 | 19380 | 23 | 63469610 |
Weight gain poor | 49.03 | 13.98 | 16 | 19373 | 900 | 63468733 |
Atrial septal defect | 49.01 | 13.98 | 29 | 19360 | 6909 | 63462724 |
Diabetes mellitus inadequate control | 48.85 | 13.98 | 39 | 19350 | 15087 | 63454546 |
Paraesthesia oral | 48.47 | 13.98 | 43 | 19346 | 19213 | 63450420 |
Neonatal gastrointestinal haemorrhage | 47.65 | 13.98 | 8 | 19381 | 17 | 63469616 |
Death | 45.74 | 13.98 | 29 | 19360 | 374352 | 63095281 |
Foetal heart rate deceleration abnormality | 44.70 | 13.98 | 13 | 19376 | 496 | 63469137 |
Rectal cancer metastatic | 43.49 | 13.98 | 11 | 19378 | 245 | 63469388 |
Bronchopulmonary dysplasia | 42.23 | 13.98 | 12 | 19377 | 421 | 63469212 |
Placental insufficiency | 41.94 | 13.98 | 16 | 19373 | 1425 | 63468208 |
Polyhydramnios | 41.32 | 13.98 | 18 | 19371 | 2253 | 63467380 |
Off label use | 41.01 | 13.98 | 348 | 19041 | 674114 | 62795519 |
Joint swelling | 40.54 | 13.98 | 25 | 19364 | 327641 | 63141992 |
Amniotic cavity infection | 40.30 | 13.98 | 15 | 19374 | 1248 | 63468385 |
Asthenia | 40.04 | 13.98 | 35 | 19354 | 383569 | 63086064 |
Skin weeping | 39.69 | 13.98 | 13 | 19376 | 740 | 63468893 |
Foetal distress syndrome | 39.46 | 13.98 | 15 | 19374 | 1323 | 63468310 |
Arthropathy | 38.34 | 13.98 | 12 | 19377 | 234780 | 63234853 |
Hydrops foetalis | 38.21 | 13.98 | 12 | 19377 | 596 | 63469037 |
Cervical incompetence | 38.04 | 13.98 | 12 | 19377 | 605 | 63469028 |
Foetal non-stress test abnormal | 37.47 | 13.98 | 7 | 19382 | 33 | 63469600 |
Catarrh | 37.33 | 13.98 | 15 | 19374 | 1534 | 63468099 |
Hypotonia neonatal | 36.86 | 13.98 | 14 | 19375 | 1232 | 63468401 |
Drug intolerance | 36.21 | 13.98 | 25 | 19364 | 308636 | 63160997 |
HELLP syndrome | 35.53 | 13.98 | 13 | 19376 | 1031 | 63468602 |
Steroid dependence | 35.44 | 13.98 | 15 | 19374 | 1749 | 63467884 |
Neonatal cholestasis | 35.25 | 13.98 | 7 | 19382 | 48 | 63469585 |
Procedural pain | 35.21 | 13.98 | 38 | 19351 | 21531 | 63448102 |
Fall | 33.94 | 13.98 | 42 | 19347 | 392292 | 63077341 |
Burns second degree | 33.79 | 13.98 | 15 | 19374 | 1963 | 63467670 |
Glossodynia | 33.30 | 13.98 | 7 | 19382 | 178869 | 63290764 |
Multiple drug therapy | 33.21 | 13.98 | 18 | 19371 | 3628 | 63466005 |
Therapeutic product effect decreased | 33.14 | 13.98 | 9 | 19380 | 193178 | 63276455 |
Blood pressure inadequately controlled | 33.07 | 13.98 | 20 | 19369 | 4958 | 63464675 |
Acute pulmonary oedema | 32.87 | 13.98 | 24 | 19365 | 8134 | 63461499 |
Ophthalmic herpes simplex | 32.80 | 13.98 | 10 | 19379 | 450 | 63469183 |
Umbilical erythema | 32.63 | 13.98 | 7 | 19382 | 73 | 63469560 |
Neonatal respiratory failure | 32.59 | 13.98 | 9 | 19380 | 284 | 63469349 |
Hand deformity | 32.37 | 13.98 | 5 | 19384 | 159452 | 63310181 |
Starvation ketoacidosis | 32.13 | 13.98 | 7 | 19382 | 79 | 63469554 |
Infantile apnoea | 31.98 | 13.98 | 12 | 19377 | 1021 | 63468612 |
Rheumatoid arthritis | 31.89 | 13.98 | 19 | 19370 | 253800 | 63215833 |
Ventricular septal defect | 30.14 | 13.98 | 18 | 19371 | 4360 | 63465273 |
Exercise tolerance decreased | 28.79 | 13.98 | 19 | 19370 | 5478 | 63464155 |
Discomfort | 28.33 | 13.98 | 8 | 19381 | 167366 | 63302267 |
Pneumocystis jirovecii pneumonia | 27.96 | 13.98 | 30 | 19359 | 16884 | 63452749 |
Gastrointestinal disorder | 27.14 | 13.98 | 95 | 19294 | 131144 | 63338489 |
Hypopnoea | 27.12 | 13.98 | 16 | 19373 | 3790 | 63465843 |
Corneal perforation | 27.03 | 13.98 | 9 | 19380 | 539 | 63469094 |
Neonatal intestinal perforation | 26.52 | 13.98 | 5 | 19384 | 25 | 63469608 |
Toxicity to various agents | 26.45 | 13.98 | 22 | 19367 | 247228 | 63222405 |
Maternal condition affecting foetus | 25.98 | 13.98 | 7 | 19382 | 201 | 63469432 |
Pemphigus | 25.65 | 13.98 | 12 | 19377 | 183714 | 63285919 |
Hepatic enzyme increased | 25.61 | 13.98 | 15 | 19374 | 202313 | 63267320 |
Libido increased | 25.58 | 13.98 | 11 | 19378 | 1334 | 63468299 |
Pyrexia | 25.52 | 13.98 | 237 | 19152 | 470241 | 62999392 |
Wound | 25.49 | 13.98 | 9 | 19380 | 163254 | 63306379 |
Vomiting | 25.34 | 13.98 | 87 | 19302 | 559530 | 62910103 |
White matter lesion | 24.96 | 13.98 | 12 | 19377 | 1883 | 63467750 |
Pericarditis | 24.80 | 13.98 | 5 | 19384 | 131574 | 63338059 |
Eczema | 24.51 | 13.98 | 39 | 19350 | 32252 | 63437381 |
Perioral dermatitis | 24.25 | 13.98 | 7 | 19382 | 260 | 63469373 |
Sepsis neonatal | 24.21 | 13.98 | 8 | 19381 | 468 | 63469165 |
Pulmonary hypoplasia | 23.61 | 13.98 | 7 | 19382 | 286 | 63469347 |
Skin burning sensation | 23.58 | 13.98 | 24 | 19365 | 12710 | 63456923 |
Cerebral haemorrhage neonatal | 23.46 | 13.98 | 6 | 19383 | 140 | 63469493 |
Soft tissue injury | 23.41 | 13.98 | 11 | 19378 | 1641 | 63467992 |
Cholestasis of pregnancy | 23.24 | 13.98 | 10 | 19379 | 1215 | 63468418 |
Arthralgia | 22.90 | 13.98 | 93 | 19296 | 569617 | 62900016 |
Anti-cyclic citrullinated peptide antibody positive | 22.78 | 13.98 | 4 | 19385 | 116208 | 63353425 |
Meningitis chemical | 22.77 | 13.98 | 6 | 19383 | 158 | 63469475 |
Jaundice neonatal | 22.44 | 13.98 | 9 | 19380 | 916 | 63468717 |
Right ventricular dysfunction | 22.40 | 13.98 | 11 | 19378 | 1808 | 63467825 |
Pneumocephalus | 22.21 | 13.98 | 6 | 19383 | 174 | 63469459 |
Gestational hypertension | 22.20 | 13.98 | 12 | 19377 | 2405 | 63467228 |
Intraventricular haemorrhage neonatal | 22.18 | 13.98 | 6 | 19383 | 175 | 63469458 |
Pulmonary valve stenosis congenital | 22.15 | 13.98 | 6 | 19383 | 176 | 63469457 |
Hostility | 22.10 | 13.98 | 11 | 19378 | 1861 | 63467772 |
Nightmare | 21.66 | 13.98 | 28 | 19361 | 19166 | 63450467 |
Drug ineffective for unapproved indication | 21.65 | 13.98 | 38 | 19351 | 34025 | 63435608 |
Aplastic anaemia | 21.40 | 13.98 | 20 | 19369 | 9549 | 63460084 |
Meconium abnormal | 21.28 | 13.98 | 3 | 19386 | 0 | 63469633 |
Pulmonary valve disease | 21.22 | 13.98 | 4 | 19385 | 20 | 63469613 |
Post-traumatic neck syndrome | 21.04 | 13.98 | 11 | 19378 | 2063 | 63467570 |
Diarrhoea | 20.67 | 13.98 | 131 | 19258 | 715235 | 62754398 |
Decreased appetite | 20.53 | 13.98 | 28 | 19361 | 251024 | 63218609 |
Foetal anaemia | 20.42 | 13.98 | 5 | 19384 | 97 | 63469536 |
Sternal fracture | 20.18 | 13.98 | 11 | 19378 | 2243 | 63467390 |
Breech presentation | 20.08 | 13.98 | 9 | 19380 | 1205 | 63468428 |
Small for dates baby | 19.73 | 13.98 | 13 | 19376 | 3738 | 63465895 |
Toxic anterior segment syndrome | 19.72 | 13.98 | 10 | 19379 | 1761 | 63467872 |
Pulmonary haemorrhage neonatal | 19.60 | 13.98 | 4 | 19385 | 32 | 63469601 |
Stomatitis | 19.45 | 13.98 | 9 | 19380 | 138716 | 63330917 |
Alopecia | 19.25 | 13.98 | 47 | 19342 | 337489 | 63132144 |
Oesophageal atresia | 19.22 | 13.98 | 7 | 19382 | 548 | 63469085 |
Delayed delivery | 19.08 | 13.98 | 4 | 19385 | 37 | 63469596 |
Papule | 19.07 | 13.98 | 15 | 19374 | 5676 | 63463957 |
Tracheo-oesophageal fistula | 18.78 | 13.98 | 7 | 19382 | 585 | 63469048 |
Skin infection | 18.70 | 13.98 | 23 | 19366 | 14979 | 63454654 |
Serratia infection | 18.64 | 13.98 | 8 | 19381 | 965 | 63468668 |
Synovitis | 18.35 | 13.98 | 18 | 19371 | 186900 | 63282733 |
Anaemia neonatal | 18.33 | 13.98 | 6 | 19383 | 341 | 63469292 |
Angiotensin converting enzyme inhibitor foetopathy | 18.29 | 13.98 | 4 | 19385 | 46 | 63469587 |
Gingival pain | 18.14 | 13.98 | 17 | 19372 | 8145 | 63461488 |
Retroplacental haematoma | 18.07 | 13.98 | 5 | 19384 | 159 | 63469474 |
Contraindicated product administered | 18.07 | 13.98 | 24 | 19365 | 217624 | 63252009 |
Seizure | 17.99 | 13.98 | 9 | 19380 | 132625 | 63337008 |
Tachycardia foetal | 17.89 | 13.98 | 5 | 19384 | 165 | 63469468 |
Skin plaque | 17.86 | 13.98 | 17 | 19372 | 8303 | 63461330 |
Jarisch-Herxheimer reaction | 17.84 | 13.98 | 6 | 19383 | 371 | 63469262 |
Neonatal respiratory distress | 17.56 | 13.98 | 6 | 19383 | 389 | 63469244 |
Human herpesvirus 6 infection | 17.40 | 13.98 | 11 | 19378 | 2946 | 63466687 |
Foetal growth abnormality | 17.24 | 13.98 | 4 | 19385 | 61 | 63469572 |
Twin pregnancy | 17.21 | 13.98 | 8 | 19381 | 1165 | 63468468 |
Duodenal ulcer perforation | 17.10 | 13.98 | 3 | 19386 | 87206 | 63382427 |
Neutropenia | 17.01 | 13.98 | 17 | 19372 | 174988 | 63294645 |
Pain | 16.89 | 13.98 | 145 | 19244 | 740483 | 62729150 |
Ultrasound uterus abnormal | 16.73 | 13.98 | 4 | 19385 | 70 | 63469563 |
Gait disturbance | 16.46 | 13.98 | 19 | 19370 | 183159 | 63286474 |
Systemic lupus erythematosus | 16.38 | 13.98 | 24 | 19365 | 208894 | 63260739 |
Concussion | 16.35 | 13.98 | 17 | 19372 | 9227 | 63460406 |
Impetigo | 16.16 | 13.98 | 8 | 19381 | 1338 | 63468295 |
Right aortic arch | 16.11 | 13.98 | 5 | 19384 | 239 | 63469394 |
Breast injury | 15.99 | 13.98 | 4 | 19385 | 85 | 63469548 |
Hirsutism | 15.89 | 13.98 | 8 | 19381 | 1387 | 63468246 |
Rash erythematous | 15.81 | 13.98 | 38 | 19351 | 42472 | 63427161 |
Ulcerative keratitis | 15.75 | 13.98 | 10 | 19379 | 2700 | 63466933 |
Stenotrophomonas infection | 15.71 | 13.98 | 9 | 19380 | 2018 | 63467615 |
Medication error | 15.59 | 13.98 | 43 | 19346 | 52241 | 63417392 |
Adenovirus infection | 15.52 | 13.98 | 11 | 19378 | 3560 | 63466073 |
Death neonatal | 15.40 | 13.98 | 7 | 19382 | 968 | 63468665 |
Swelling | 15.18 | 13.98 | 39 | 19350 | 275339 | 63194294 |
Scab | 15.05 | 13.98 | 15 | 19374 | 7748 | 63461885 |
Shared psychotic disorder | 14.93 | 13.98 | 3 | 19386 | 22 | 63469611 |
Corneal neovascularisation | 14.91 | 13.98 | 4 | 19385 | 113 | 63469520 |
Intermittent positive pressure breathing | 14.70 | 13.98 | 3 | 19386 | 24 | 63469609 |
Adrenal haematoma | 14.70 | 13.98 | 3 | 19386 | 24 | 63469609 |
Helicobacter infection | 14.68 | 13.98 | 5 | 19384 | 92780 | 63376853 |
Cardiac failure congestive | 14.59 | 13.98 | 5 | 19384 | 92428 | 63377205 |
Dry gangrene | 14.56 | 13.98 | 6 | 19383 | 654 | 63468979 |
Pustule | 14.41 | 13.98 | 8 | 19381 | 1691 | 63467942 |
Umbilical cord prolapse | 14.38 | 13.98 | 3 | 19386 | 27 | 63469606 |
Rheumatoid factor positive | 14.34 | 13.98 | 4 | 19385 | 84402 | 63385231 |
Hypopituitarism | 14.31 | 13.98 | 7 | 19382 | 1141 | 63468492 |
Decreased insulin requirement | 14.23 | 13.98 | 4 | 19385 | 135 | 63469498 |
Fatigue | 14.13 | 13.98 | 189 | 19200 | 887839 | 62581794 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature baby | 960.65 | 19.21 | 338 | 13021 | 19295 | 34924277 |
Low birth weight baby | 597.06 | 19.21 | 189 | 13170 | 7716 | 34935856 |
Foetal exposure during pregnancy | 550.19 | 19.21 | 275 | 13084 | 37826 | 34905746 |
Appendicolith | 419.55 | 19.21 | 148 | 13211 | 8453 | 34935119 |
Appendicitis | 348.06 | 19.21 | 150 | 13209 | 14657 | 34928915 |
Drug eruption | 311.66 | 19.21 | 152 | 13207 | 19746 | 34923826 |
Stress | 296.30 | 19.21 | 169 | 13190 | 30178 | 34913394 |
Cardiogenic shock | 269.97 | 19.21 | 152 | 13207 | 26466 | 34917106 |
Stomatitis | 225.29 | 19.21 | 161 | 13198 | 42353 | 34901219 |
Hepatic function abnormal | 214.62 | 19.21 | 159 | 13200 | 44204 | 34899368 |
Ascites | 201.16 | 19.21 | 156 | 13203 | 46415 | 34897157 |
Urticaria | 192.57 | 19.21 | 172 | 13187 | 62205 | 34881367 |
Hypersensitivity | 183.86 | 19.21 | 166 | 13193 | 60869 | 34882703 |
Ventricular fibrillation | 179.88 | 19.21 | 111 | 13248 | 22843 | 34920729 |
Blood phosphorus increased | 174.05 | 19.21 | 76 | 13283 | 7645 | 34935927 |
Abdominal distension | 168.17 | 19.21 | 155 | 13204 | 58337 | 34885235 |
Hyponatraemia | 167.34 | 19.21 | 181 | 13178 | 82510 | 34861062 |
Epistaxis | 164.83 | 19.21 | 153 | 13206 | 58098 | 34885474 |
Multiple organ dysfunction syndrome | 146.89 | 19.21 | 163 | 13196 | 76403 | 34867169 |
Muscle spasms | 139.29 | 19.21 | 157 | 13202 | 74844 | 34868728 |
Pain in extremity | 124.70 | 19.21 | 194 | 13165 | 126319 | 34817253 |
Patent ductus arteriosus | 116.48 | 19.21 | 45 | 13314 | 3309 | 34940263 |
Neonatal respiratory distress syndrome | 105.07 | 19.21 | 44 | 13315 | 3990 | 34939582 |
Constipation | 97.77 | 19.21 | 182 | 13177 | 136800 | 34806772 |
Atrial septal defect | 93.72 | 19.21 | 49 | 13310 | 7343 | 34936229 |
Sepsis | 88.75 | 19.21 | 196 | 13163 | 166365 | 34777207 |
Abdominal pain | 84.31 | 19.21 | 190 | 13169 | 163428 | 34780144 |
General physical health deterioration | 79.95 | 19.21 | 161 | 13198 | 128108 | 34815464 |
Dry mouth | 79.02 | 19.21 | 76 | 13283 | 30089 | 34913483 |
Myasthenia gravis | 76.73 | 19.21 | 42 | 13317 | 6898 | 34936674 |
Foetal growth restriction | 72.10 | 19.21 | 34 | 13325 | 4083 | 34939489 |
Drug ineffective | 69.23 | 19.21 | 350 | 13009 | 456401 | 34487171 |
Blood uric acid increased | 66.47 | 19.21 | 43 | 13316 | 9581 | 34933991 |
Toxicity to various agents | 58.12 | 19.21 | 5 | 13354 | 200357 | 34743215 |
Drug therapy | 45.72 | 19.21 | 17 | 13342 | 1124 | 34942448 |
Analgesic therapy | 44.18 | 19.21 | 16 | 13343 | 982 | 34942590 |
Blood cholesterol increased | 43.24 | 19.21 | 46 | 13313 | 20497 | 34923075 |
Psoriasis | 41.60 | 19.21 | 62 | 13297 | 38750 | 34904822 |
Foetal heart rate deceleration abnormality | 41.53 | 19.21 | 13 | 13346 | 508 | 34943064 |
Sleep disorder therapy | 40.11 | 19.21 | 15 | 13344 | 1008 | 34942564 |
Septum pellucidum agenesis | 37.30 | 19.21 | 8 | 13351 | 65 | 34943507 |
Steroid withdrawal syndrome | 36.77 | 19.21 | 10 | 13349 | 236 | 34943336 |
Polydipsia | 35.99 | 19.21 | 21 | 13338 | 3894 | 34939678 |
Vomiting | 34.64 | 19.21 | 186 | 13173 | 247435 | 34696137 |
Incorrect route of product administration | 34.39 | 19.21 | 35 | 13324 | 14810 | 34928762 |
Maternal exposure during pregnancy | 34.02 | 19.21 | 22 | 13337 | 4896 | 34938676 |
Hyperphosphataemia | 33.56 | 19.21 | 21 | 13338 | 4416 | 34939156 |
Acute kidney injury | 32.93 | 19.21 | 41 | 13318 | 304947 | 34638625 |
Iron deficiency | 32.21 | 19.21 | 22 | 13337 | 5359 | 34938213 |
Asthenia | 32.06 | 19.21 | 28 | 13331 | 245223 | 34698349 |
Condition aggravated | 31.50 | 19.21 | 151 | 13208 | 192045 | 34751527 |
Respiratory disorder neonatal | 30.20 | 19.21 | 14 | 13345 | 1616 | 34941956 |
Congenital hearing disorder | 29.17 | 19.21 | 7 | 13352 | 98 | 34943474 |
Somnolence | 29.11 | 19.21 | 101 | 13258 | 111015 | 34832557 |
Neonatal respiratory failure | 28.57 | 19.21 | 9 | 13350 | 359 | 34943213 |
Congenital cystic lung | 28.04 | 19.21 | 8 | 13351 | 226 | 34943346 |
Corneal endotheliitis | 27.95 | 19.21 | 6 | 13353 | 49 | 34943523 |
Perioral dermatitis | 26.79 | 19.21 | 7 | 13352 | 141 | 34943431 |
Death | 25.76 | 19.21 | 73 | 13286 | 397976 | 34545596 |
Fall | 25.50 | 19.21 | 24 | 13335 | 202861 | 34740711 |
Neuralgia | 25.23 | 19.21 | 30 | 13329 | 15083 | 34928489 |
Drug abuse | 24.92 | 19.21 | 4 | 13355 | 99092 | 34844480 |
Ciliary hyperaemia | 24.49 | 19.21 | 5 | 13354 | 31 | 34943541 |
Hydrops foetalis | 24.41 | 19.21 | 10 | 13349 | 857 | 34942715 |
Cryptorchism | 24.36 | 19.21 | 13 | 13346 | 2028 | 34941544 |
Bronchopulmonary dysplasia | 24.29 | 19.21 | 9 | 13350 | 589 | 34942983 |
Persistent corneal epithelial defect | 23.97 | 19.21 | 5 | 13354 | 35 | 34943537 |
Polyhydramnios | 23.30 | 19.21 | 7 | 13352 | 238 | 34943334 |
Anaplastic astrocytoma | 23.29 | 19.21 | 6 | 13353 | 114 | 34943458 |
Vertical infection transmission | 22.77 | 19.21 | 4 | 13355 | 9 | 34943563 |
Hypothalamic pituitary adrenal axis suppression | 22.08 | 19.21 | 6 | 13353 | 141 | 34943431 |
Congenital pulmonary valve atresia | 21.95 | 19.21 | 5 | 13354 | 55 | 34943517 |
Skin indentation | 21.94 | 19.21 | 4 | 13355 | 12 | 34943560 |
Haemangioma congenital | 21.79 | 19.21 | 8 | 13351 | 510 | 34943062 |
Meningitis aseptic | 21.26 | 19.21 | 14 | 13345 | 3210 | 34940362 |
Trisomy 21 | 20.82 | 19.21 | 8 | 13351 | 579 | 34942993 |
Ventricular septal defect | 20.79 | 19.21 | 15 | 13344 | 3986 | 34939586 |
Shared psychotic disorder | 20.67 | 19.21 | 4 | 13355 | 18 | 34943554 |
Pulmonary vasculitis | 20.66 | 19.21 | 8 | 13351 | 591 | 34942981 |
Bradycardia foetal | 20.57 | 19.21 | 7 | 13352 | 357 | 34943215 |
Large for dates baby | 20.56 | 19.21 | 9 | 13350 | 909 | 34942663 |
Craniosynostosis | 20.28 | 19.21 | 7 | 13352 | 373 | 34943199 |
Cerebral ventricle dilatation | 20.12 | 19.21 | 9 | 13350 | 957 | 34942615 |
Cough | 19.76 | 19.21 | 17 | 13342 | 150123 | 34793449 |
Back pain | 19.72 | 19.21 | 11 | 13348 | 121778 | 34821794 |
Nausea | 19.58 | 19.21 | 207 | 13152 | 339701 | 34603871 |
Cardiac failure congestive | 19.56 | 19.21 | 4 | 13355 | 83266 | 34860306 |
Haemoglobin decreased | 19.43 | 19.21 | 11 | 13348 | 120761 | 34822811 |
Glioblastoma | 19.32 | 19.21 | 9 | 13350 | 1050 | 34942522 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature delivery | 1370.27 | 13.59 | 444 | 25564 | 23023 | 79695357 |
Maternal exposure during pregnancy | 792.07 | 13.59 | 514 | 25494 | 136024 | 79582356 |
Exposure during pregnancy | 643.83 | 13.59 | 404 | 25604 | 100728 | 79617652 |
Appendicolith | 439.02 | 13.59 | 147 | 25861 | 8404 | 79709976 |
Appendicitis | 318.54 | 13.59 | 149 | 25859 | 20645 | 79697735 |
Drug eruption | 245.65 | 13.59 | 162 | 25846 | 43773 | 79674607 |
Cardiogenic shock | 218.56 | 13.59 | 148 | 25860 | 41766 | 79676614 |
Premature labour | 206.50 | 13.59 | 84 | 25924 | 8306 | 79710074 |
Stress | 204.72 | 13.59 | 185 | 25823 | 79427 | 79638953 |
Hepatic function abnormal | 192.14 | 13.59 | 172 | 25836 | 72935 | 79645445 |
Ascites | 173.76 | 13.59 | 165 | 25843 | 75397 | 79642983 |
Ventricular fibrillation | 164.67 | 13.59 | 112 | 25896 | 31814 | 79686566 |
Blood phosphorus increased | 164.18 | 13.59 | 76 | 25932 | 10271 | 79708109 |
Computerised tomogram thorax abnormal | 158.29 | 13.59 | 50 | 25958 | 2369 | 79716011 |
Psoriasis | 123.24 | 13.59 | 149 | 25859 | 89438 | 79628942 |
Epistaxis | 122.72 | 13.59 | 166 | 25842 | 111349 | 79607031 |
Abdominal distension | 122.50 | 13.59 | 172 | 25836 | 119478 | 79598902 |
Pre-eclampsia | 122.03 | 13.59 | 55 | 25953 | 6986 | 79711394 |
Multiple organ dysfunction syndrome | 121.84 | 13.59 | 172 | 25836 | 120074 | 79598306 |
Urticaria | 120.11 | 13.59 | 216 | 25792 | 184985 | 79533395 |
Computerised tomogram thorax | 119.19 | 13.59 | 28 | 25980 | 422 | 79717958 |
Live birth | 109.30 | 13.59 | 71 | 25937 | 18673 | 79699707 |
Steroid withdrawal syndrome | 106.08 | 13.59 | 28 | 25980 | 693 | 79717687 |
Caesarean section | 94.71 | 13.59 | 56 | 25952 | 12479 | 79705901 |
Hyponatraemia | 92.59 | 13.59 | 189 | 25819 | 177659 | 79540721 |
Stomatitis | 88.58 | 13.59 | 166 | 25842 | 146591 | 79571789 |
Premature rupture of membranes | 84.17 | 13.59 | 36 | 25972 | 4033 | 79714347 |
Product use in unapproved indication | 83.09 | 13.59 | 223 | 25785 | 250136 | 79468244 |
Normal newborn | 82.22 | 13.59 | 42 | 25966 | 7030 | 79711350 |
Premature baby | 76.73 | 13.59 | 33 | 25975 | 3747 | 79714633 |
Muscle spasms | 74.14 | 13.59 | 171 | 25837 | 174559 | 79543821 |
Corneal endotheliitis | 71.48 | 13.59 | 14 | 25994 | 82 | 79718298 |
Atelectasis | 71.36 | 13.59 | 69 | 25939 | 32188 | 79686192 |
Toxicity to various agents | 70.11 | 13.59 | 25 | 25983 | 421515 | 79296865 |
Gestational diabetes | 69.20 | 13.59 | 36 | 25972 | 6257 | 79712123 |
Drug ineffective | 67.47 | 13.59 | 590 | 25418 | 1080323 | 78638057 |
Myasthenia gravis | 67.11 | 13.59 | 42 | 25966 | 10357 | 79708023 |
Sepsis | 66.46 | 13.59 | 216 | 25792 | 269212 | 79449168 |
Constipation | 66.32 | 13.59 | 223 | 25785 | 282827 | 79435553 |
Preterm premature rupture of membranes | 65.77 | 13.59 | 22 | 25986 | 1251 | 79717129 |
Hypersensitivity | 62.67 | 13.59 | 208 | 25800 | 262031 | 79456349 |
Blood uric acid increased | 62.13 | 13.59 | 44 | 25964 | 13316 | 79705064 |
Off label use | 57.43 | 13.59 | 497 | 25511 | 906718 | 78811662 |
Chronic sinusitis | 56.22 | 13.59 | 41 | 25967 | 12985 | 79705395 |
Asthenia | 55.68 | 13.59 | 51 | 25957 | 511638 | 79206742 |
Macular degeneration | 54.38 | 13.59 | 38 | 25970 | 11258 | 79707122 |
Perioral dermatitis | 52.23 | 13.59 | 14 | 25994 | 368 | 79718012 |
Skin exfoliation | 51.63 | 13.59 | 76 | 25932 | 55024 | 79663356 |
Foetal growth restriction | 51.39 | 13.59 | 21 | 25987 | 2098 | 79716282 |
Incorrect route of product administration | 51.12 | 13.59 | 60 | 25948 | 34869 | 79683511 |
Pain in extremity | 49.18 | 13.59 | 242 | 25766 | 364296 | 79354084 |
Drug therapy | 47.50 | 13.59 | 17 | 25991 | 1184 | 79717196 |
Analgesic therapy | 46.48 | 13.59 | 16 | 25992 | 993 | 79717387 |
Skin weeping | 45.90 | 13.59 | 16 | 25992 | 1031 | 79717349 |
Paraesthesia oral | 45.67 | 13.59 | 44 | 25964 | 20427 | 79697953 |
Oligohydramnios | 44.77 | 13.59 | 22 | 25986 | 3390 | 79714990 |
Catarrh | 44.16 | 13.59 | 19 | 25989 | 2159 | 79716221 |
Burns second degree | 43.86 | 13.59 | 20 | 25988 | 2608 | 79715772 |
Steroid dependence | 43.85 | 13.59 | 20 | 25988 | 2610 | 79715770 |
Sleep disorder therapy | 42.41 | 13.59 | 15 | 25993 | 1009 | 79717371 |
Fall | 41.73 | 13.59 | 59 | 25949 | 487570 | 79230810 |
Amniotic cavity infection | 41.57 | 13.59 | 14 | 25994 | 813 | 79717567 |
Polyhydramnios | 41.56 | 13.59 | 17 | 25991 | 1703 | 79716677 |
Abdominal pain | 41.24 | 13.59 | 242 | 25766 | 389327 | 79329053 |
General physical health deterioration | 39.45 | 13.59 | 186 | 25822 | 275052 | 79443328 |
Ophthalmic herpes simplex | 39.24 | 13.59 | 13 | 25995 | 717 | 79717663 |
Dry mouth | 38.24 | 13.59 | 87 | 25921 | 87932 | 79630448 |
HELLP syndrome | 37.98 | 13.59 | 13 | 25995 | 793 | 79717587 |
Placental insufficiency | 37.38 | 13.59 | 14 | 25994 | 1109 | 79717271 |
Acute kidney injury | 36.85 | 13.59 | 71 | 25937 | 519333 | 79199047 |
Hypoxia | 36.25 | 13.59 | 94 | 25914 | 103149 | 79615231 |
Rectal cancer metastatic | 36.03 | 13.59 | 11 | 25997 | 465 | 79717915 |
Shared psychotic disorder | 35.88 | 13.59 | 7 | 26001 | 40 | 79718340 |
Pneumocystis jirovecii pneumonia | 35.12 | 13.59 | 48 | 25960 | 32460 | 79685920 |
Ulcerative keratitis | 34.64 | 13.59 | 19 | 25989 | 3670 | 79714710 |
Nausea | 34.14 | 13.59 | 468 | 25540 | 956728 | 78761652 |
Drug abuse | 34.03 | 13.59 | 6 | 26002 | 162685 | 79555695 |
Eczema | 33.57 | 13.59 | 53 | 25955 | 40765 | 79677615 |
Joint swelling | 33.51 | 13.59 | 27 | 25981 | 288619 | 79429761 |
Arthralgia | 33.35 | 13.59 | 87 | 25921 | 571716 | 79146664 |
Death | 33.19 | 13.59 | 86 | 25922 | 566428 | 79151952 |
Procedural pain | 32.70 | 13.59 | 39 | 25969 | 23045 | 79695335 |
Hyperphosphataemia | 31.98 | 13.59 | 22 | 25986 | 6354 | 79712026 |
Pulmonary valve stenosis congenital | 31.68 | 13.59 | 5 | 26003 | 5 | 79718375 |
Polydipsia | 31.28 | 13.59 | 22 | 25986 | 6583 | 79711797 |
Cerebral haemorrhage neonatal | 31.20 | 13.59 | 5 | 26003 | 6 | 79718374 |
Corneal perforation | 30.93 | 13.59 | 11 | 25997 | 752 | 79717628 |
Hypothalamic pituitary adrenal axis suppression | 30.81 | 13.59 | 9 | 25999 | 326 | 79718054 |
Cervical incompetence | 30.81 | 13.59 | 10 | 25998 | 517 | 79717863 |
Hypopnoea | 30.60 | 13.59 | 20 | 25988 | 5309 | 79713071 |
Hypotension | 30.51 | 13.59 | 61 | 25947 | 440256 | 79278124 |
Diabetes mellitus inadequate control | 29.55 | 13.59 | 38 | 25970 | 24226 | 79694154 |
Gastrointestinal disorder | 29.19 | 13.59 | 97 | 25911 | 122108 | 79596272 |
Haemoglobin decreased | 28.07 | 13.59 | 19 | 25989 | 222100 | 79496280 |
Starvation ketoacidosis | 27.89 | 13.59 | 7 | 26001 | 141 | 79718239 |
Multiple drug therapy | 27.65 | 13.59 | 17 | 25991 | 4061 | 79714319 |
Rheumatoid arthritis | 27.48 | 13.59 | 17 | 25991 | 208453 | 79509927 |
Maternal condition affecting foetus | 27.01 | 13.59 | 7 | 26001 | 161 | 79718219 |
Arthropathy | 26.95 | 13.59 | 12 | 25996 | 177099 | 79541281 |
Dehydration | 26.63 | 13.59 | 25 | 25983 | 248162 | 79470218 |
Somnolence | 26.24 | 13.59 | 150 | 25858 | 238831 | 79479549 |
Diarrhoea | 26.24 | 13.59 | 174 | 25834 | 880315 | 78838065 |
Nightmare | 26.16 | 13.59 | 37 | 25971 | 25824 | 79692556 |
Foetal hypokinesia | 25.80 | 13.59 | 8 | 26000 | 356 | 79718024 |
Parosmia | 25.66 | 13.59 | 20 | 25988 | 6994 | 79711386 |
Blood pressure inadequately controlled | 25.66 | 13.59 | 19 | 25989 | 6158 | 79712222 |
Condition aggravated | 25.27 | 13.59 | 262 | 25746 | 500862 | 79217518 |
Gingival pain | 25.26 | 13.59 | 22 | 25986 | 8976 | 79709404 |
Skin burning sensation | 24.95 | 13.59 | 26 | 25982 | 13246 | 79705134 |
Cholestasis of pregnancy | 24.63 | 13.59 | 10 | 25998 | 983 | 79717397 |
Foetal exposure during pregnancy | 24.48 | 13.59 | 18 | 25990 | 5772 | 79712608 |
Gestational hypertension | 24.31 | 13.59 | 12 | 25996 | 1867 | 79716513 |
Cardiac failure congestive | 22.70 | 13.59 | 9 | 25999 | 142393 | 79575987 |
Persistent corneal epithelial defect | 22.57 | 13.59 | 5 | 26003 | 57 | 79718323 |
Decreased appetite | 22.39 | 13.59 | 49 | 25959 | 342369 | 79376011 |
Blood cholesterol increased | 22.31 | 13.59 | 69 | 25939 | 83651 | 79634729 |
Therapeutic product effect decreased | 22.10 | 13.59 | 13 | 25995 | 163850 | 79554530 |
Anaplastic astrocytoma | 22.09 | 13.59 | 6 | 26002 | 166 | 79718214 |
Iron deficiency | 22.08 | 13.59 | 22 | 25986 | 10632 | 79707748 |
Soft tissue injury | 21.94 | 13.59 | 11 | 25997 | 1770 | 79716610 |
Ciliary hyperaemia | 21.63 | 13.59 | 5 | 26003 | 70 | 79718310 |
Neutropenia | 21.55 | 13.59 | 38 | 25970 | 287672 | 79430708 |
Bradycardia | 20.91 | 13.59 | 9 | 25999 | 135548 | 79582832 |
Libido increased | 20.73 | 13.59 | 11 | 25997 | 1990 | 79716390 |
Delayed delivery | 20.48 | 13.59 | 4 | 26004 | 23 | 79718357 |
Meningitis chemical | 20.42 | 13.59 | 6 | 26002 | 222 | 79718158 |
Scab | 20.40 | 13.59 | 21 | 25987 | 10551 | 79707829 |
Post-traumatic neck syndrome | 20.26 | 13.59 | 11 | 25997 | 2083 | 79716297 |
Acute pulmonary oedema | 20.08 | 13.59 | 24 | 25984 | 14206 | 79704174 |
Pulmonary vasculitis | 20.03 | 13.59 | 8 | 26000 | 753 | 79717627 |
Impaired quality of life | 19.87 | 13.59 | 24 | 25984 | 14362 | 79704018 |
Foetal distress syndrome | 19.59 | 13.59 | 7 | 26001 | 485 | 79717895 |
Patent ductus arteriosus | 19.50 | 13.59 | 5 | 26003 | 110 | 79718270 |
Hand deformity | 19.34 | 13.59 | 5 | 26003 | 103914 | 79614466 |
Exercise tolerance decreased | 19.30 | 13.59 | 19 | 25989 | 9052 | 79709328 |
Depressed level of consciousness | 19.28 | 13.59 | 4 | 26004 | 96648 | 79621732 |
Hostility | 19.25 | 13.59 | 11 | 25997 | 2299 | 79716081 |
Glossodynia | 19.18 | 13.59 | 5 | 26003 | 103332 | 79615048 |
Neuritis | 19.16 | 13.59 | 10 | 25998 | 1748 | 79716632 |
Retroplacental haematoma | 18.89 | 13.59 | 5 | 26003 | 125 | 79718255 |
Hepatic enzyme increased | 18.88 | 13.59 | 19 | 25989 | 182591 | 79535789 |
Gait disturbance | 18.83 | 13.59 | 24 | 25984 | 207482 | 79510898 |
Twin pregnancy | 18.77 | 13.59 | 8 | 26000 | 888 | 79717492 |
Renal failure | 18.49 | 13.59 | 23 | 25985 | 200945 | 79517435 |
Coma | 18.43 | 13.59 | 5 | 26003 | 100644 | 79617736 |
Atrial septal defect | 18.33 | 13.59 | 10 | 25998 | 1912 | 79716468 |
Sternal fracture | 18.32 | 13.59 | 11 | 25997 | 2519 | 79715861 |
Seizure | 18.02 | 13.59 | 21 | 25987 | 188813 | 79529567 |
Pyrexia | 18.02 | 13.59 | 316 | 25692 | 678393 | 79039987 |
Low birth weight baby | 17.98 | 13.59 | 7 | 26001 | 616 | 79717764 |
White blood cell count decreased | 17.91 | 13.59 | 21 | 25987 | 188267 | 79530113 |
Pneumocephalus | 17.82 | 13.59 | 6 | 26002 | 348 | 79718032 |
Rhinitis | 17.73 | 13.59 | 23 | 25985 | 14784 | 79703596 |
Glucocorticoid deficiency | 17.61 | 13.59 | 7 | 26001 | 651 | 79717729 |
Colitis ulcerative | 16.96 | 13.59 | 36 | 25972 | 34706 | 79683674 |
Skin infection | 16.84 | 13.59 | 25 | 25983 | 18220 | 79700160 |
Glioblastoma | 16.84 | 13.59 | 9 | 25999 | 1651 | 79716729 |
Delivery | 16.80 | 13.59 | 7 | 26001 | 735 | 79717645 |
Neuralgia | 16.77 | 13.59 | 35 | 25973 | 33349 | 79685031 |
Frequent bowel movements | 16.06 | 13.59 | 32 | 25976 | 29507 | 79688873 |
Transient aphasia | 16.03 | 13.59 | 6 | 26002 | 474 | 79717906 |
Overdose | 16.00 | 13.59 | 22 | 25986 | 184184 | 79534196 |
Myocardial infarction | 15.99 | 13.59 | 22 | 25986 | 184107 | 79534273 |
Dermatitis atopic | 15.93 | 13.59 | 18 | 25990 | 10038 | 79708342 |
International normalised ratio increased | 15.91 | 13.59 | 4 | 26004 | 84717 | 79633663 |
Breast injury | 15.82 | 13.59 | 4 | 26004 | 83 | 79718297 |
Rhabdomyolysis | 15.66 | 13.59 | 7 | 26001 | 103124 | 79615256 |
Meningitis aseptic | 15.66 | 13.59 | 15 | 25993 | 6913 | 79711467 |
Alanine aminotransferase increased | 15.60 | 13.59 | 18 | 25990 | 162552 | 79555828 |
Ventricular septal defect | 15.56 | 13.59 | 6 | 26002 | 515 | 79717865 |
Anti-cyclic citrullinated peptide antibody positive | 15.47 | 13.59 | 4 | 26004 | 83139 | 79635241 |
Hirsutism | 15.46 | 13.59 | 8 | 26000 | 1374 | 79717006 |
Arthritis allergic | 15.40 | 13.59 | 3 | 26005 | 17 | 79718363 |
Mucosal inflammation | 15.34 | 13.59 | 3 | 26005 | 75577 | 79642803 |
Drug ineffective for unapproved indication | 15.32 | 13.59 | 44 | 25964 | 51194 | 79667186 |
Adverse drug reaction | 15.23 | 13.59 | 52 | 25956 | 66340 | 79652040 |
Synovitis | 15.22 | 13.59 | 16 | 25992 | 150718 | 79567662 |
Self-consciousness | 15.15 | 13.59 | 4 | 26004 | 99 | 79718281 |
Medication error | 15.08 | 13.59 | 53 | 25955 | 68589 | 79649791 |
Pharyngeal erythema | 15.07 | 13.59 | 9 | 25999 | 2041 | 79716339 |
Umbilical cord prolapse | 14.98 | 13.59 | 3 | 26005 | 20 | 79718360 |
Toxic anterior segment syndrome | 14.97 | 13.59 | 10 | 25998 | 2754 | 79715626 |
Hospitalisation | 14.94 | 13.59 | 6 | 26002 | 94230 | 79624150 |
Therapeutic product effect incomplete | 14.94 | 13.59 | 88 | 25920 | 141557 | 79576823 |
Impetigo | 14.94 | 13.59 | 9 | 25999 | 2074 | 79716306 |
Foetal heart rate deceleration abnormality | 14.86 | 13.59 | 4 | 26004 | 107 | 79718273 |
Wound | 14.59 | 13.59 | 10 | 25998 | 116169 | 79602211 |
Sinusitis | 14.47 | 13.59 | 26 | 25982 | 195475 | 79522905 |
Pericarditis | 14.43 | 13.59 | 8 | 26000 | 104228 | 79614152 |
Keratitis fungal | 14.39 | 13.59 | 5 | 26003 | 319 | 79718061 |
Heart rate increased | 14.36 | 13.59 | 11 | 25997 | 120713 | 79597667 |
Back pain | 14.32 | 13.59 | 51 | 25957 | 304129 | 79414251 |
Discomfort | 14.25 | 13.59 | 12 | 25996 | 125605 | 79592775 |
Rash | 14.17 | 13.59 | 266 | 25742 | 578092 | 79140288 |
Hypokalaemia | 13.76 | 13.59 | 16 | 25992 | 144024 | 79574356 |
Fluid retention | 13.70 | 13.59 | 3 | 26005 | 69806 | 79648574 |
Decreased insulin requirement | 13.64 | 13.59 | 4 | 26004 | 147 | 79718233 |
None
Source | Code | Description |
---|---|---|
ATC | A07EA04 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFLAMMATORY AGENTS Corticosteroids acting locally |
ATC | C05AA05 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids |
ATC | D07AC01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
ATC | D07BC01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, potent, combinations with antiseptics |
ATC | D07CC01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, potent, combinations with antibiotics |
ATC | D07XC01 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, potent, other combinations |
ATC | H02AB01 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids |
ATC | R01AD06 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids |
ATC | R03BA04 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids |
ATC | S01BA06 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain |
ATC | S01BB04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids and mydriatics in combination |
ATC | S01CA05 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
ATC | S01CB04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION Corticosteroids/antiinfectives/mydriatics in combination |
ATC | S02BA07 | SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS Corticosteroids |
ATC | S03BA03 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS Corticosteroids |
ATC | S03CA06 | SENSORY ORGANS OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination |
FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
FDA EPC | N0000175576 | Corticosteroid |
CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
CHEBI has role | CHEBI:35705 | immunosuppressive agents |
CHEBI has role | CHEBI:65023 | anti-asthmatic agents |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D000893 | Anti-Inflammatory Agents |
MeSH PA | D005938 | Glucocorticoids |
MeSH PA | D006728 | Hormones |
MeSH PA | D019141 | Respiratory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Disorder of musculoskeletal system | indication | 928000 | DOID:17 |
Cerebral edema | indication | 2032001 | |
Tinea pedis | indication | 6020002 | DOID:12403 |
Berylliosis | indication | 8247009 | DOID:10322 |
Psoriasis | indication | 9014002 | DOID:8893 |
Ankylosing spondylitis | indication | 9631008 | DOID:7147 |
Rheumatic heart disease | indication | 23685000 | |
Atopic dermatitis | indication | 24079001 | DOID:3310 |
Inflammatory bowel disease | indication | 24526004 | DOID:0050589 |
Multiple sclerosis | indication | 24700007 | DOID:2377 |
Severe adrenal insufficiency | indication | 24867002 | |
Sarcoidosis | indication | 31541009 | DOID:11335 |
Idiopathic thrombocytopenic purpura | indication | 32273002 | DOID:8924 |
Psoriasis with arthropathy | indication | 33339001 | |
Crohn's disease | indication | 34000006 | |
Tendinitis | indication | 34840004 | DOID:971 |
Erythema multiforme | indication | 36715001 | |
Contact dermatitis | indication | 40275004 | DOID:2773 |
Angioedema | indication | 41291007 | DOID:1558 |
Miliary tuberculosis | indication | 47604008 | DOID:9861 |
Humoral hypercalcemia of malignancy | indication | 47709007 | |
Articular gout | indication | 48440001 | DOID:13189 |
Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
Edema of larynx | indication | 51599000 | |
Nephrotic syndrome | indication | 52254009 | DOID:1184 |
Lichen simplex chronicus | indication | 53891004 | |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Allergic rhinitis | indication | 61582004 | |
Lรถffler's syndrome | indication | 64936001 | DOID:9503 |
Pemphigus | indication | 65172003 | DOID:9182 |
Granuloma annulare | indication | 65508009 | DOID:3777 |
Tenosynovitis | indication | 67801009 | DOID:970 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Transfusion reaction due to serum protein reaction | indication | 72284000 | |
Epicondylitis | indication | 73583000 | DOID:14087 |
Acquired thrombocytopenia | indication | 74576004 | DOID:11126 |
Thyroiditis | indication | 82119001 | DOID:7166 |
Bursitis | indication | 84017003 | DOID:2965 |
Tinea corporis | indication | 84849002 | |
Autoimmune disease | indication | 85828009 | |
Infection by larvae of Trichinella spiralis | indication | 88264003 | |
Congenital hypoplastic anemia | indication | 88854002 | DOID:1339 |
Pruritus ani | indication | 90446007 | |
Acute lymphoid leukemia | indication | 91857003 | DOID:9952 |
Disorder of skin | indication | 95320005 | DOID:37 |
Dermatitis herpetiformis | indication | 111196000 | DOID:8505 |
Hodgkin's disease | indication | 118599009 | |
Non-Hodgkin's lymphoma | indication | 118601006 | |
Mycosis fungoides | indication | 118618005 | |
Aspiration pneumonitis | indication | 155597006 | |
Asthma | indication | 195967001 | DOID:2841 |
Discoid lupus erythematosus | indication | 200938002 | |
Plaque psoriasis | indication | 200965009 | |
Transplanted organ rejection | indication | 213148006 | |
Congenital adrenal hyperplasia | indication | 237751000 | |
Scalp psoriasis | indication | 238608008 | |
Adrenogenital disorder | indication | 267395000 | DOID:0050811 |
Pruritus of genital organs | indication | 267802000 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Follicular non-Hodgkin's lymphoma | indication | 308121000 | |
Disorder of eye | indication | 371405004 | DOID:5614 |
Primary adrenocortical insufficiency | indication | 373662000 | |
Adrenal cortical hypofunction | indication | 386584007 | DOID:10493 |
Tinea cruris | indication | 399029005 | |
Erythroderma | indication | 399992009 | |
Primary cutaneous T-cell lymphoma | indication | 400122007 | |
Dermatosis of scalp | indication | 402694007 | DOID:3136 |
Juvenile rheumatoid arthritis | indication | 410795001 | |
Autoimmune hemolytic anemia | indication | 413603009 | DOID:718 |
Synovitis | indication | 416209007 | DOID:2703 |
Post traumatic osteoarthritis | indication | 699262001 | |
Systemic Dermatomyositis | indication | ||
Diagnostic Test for Cushing's Syndrome | indication | ||
Erythroblastic Anemia | indication | ||
Synovitis due to Osteoarthritis | indication | ||
Transfusion Reaction Urticaria | indication | ||
Pericarditis | off-label use | 3238004 | DOID:1787 |
Chronic obstructive lung disease | off-label use | 13645005 | DOID:3083 |
West syndrome | off-label use | 28055006 | |
Vasculitis | off-label use | 31996006 | DOID:865 |
Bronchitis | off-label use | 32398004 | DOID:6132 |
Eczema | off-label use | 43116000 | |
Respiratory distress syndrome in the newborn | off-label use | 46775006 | |
Nasal polyp | off-label use | 52756005 | |
Rheumatic fever | off-label use | 58718002 | DOID:1586 |
Pseudogout | off-label use | 60782007 | |
Polymyalgia rheumatica | off-label use | 65323003 | DOID:853 |
Chronic hepatitis | off-label use | 76783007 | DOID:2237 |
Pemphigoid | off-label use | 86142006 | |
Hepatic necrosis | off-label use | 87248009 | |
Multiple myeloma | off-label use | 109989006 | DOID:9538 |
Polyarteritis nodosa | off-label use | 155441006 | DOID:9810 |
Celiac disease | off-label use | 396331005 | DOID:10608 |
Carditis | off-label use | 399617002 | |
Giant cell arteritis | off-label use | 414341000 | DOID:13375 |
Hypercalcemia associated with Sarcoidosis | off-label use | ||
Neonatal Bronchopulmonary Dysplasia | off-label use | ||
Infection by Strongyloides | contraindication | 1214006 | DOID:10955 |
Mycosis | contraindication | 3218000 | DOID:1564 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Inactive tuberculosis | contraindication | 11999007 | |
Congenital ichthyosis of skin | contraindication | 13059002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Hypercholesterolemia | contraindication | 13644009 | |
Measles | contraindication | 14189004 | DOID:8622 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Arginase deficiency | contraindication | 23501004 | DOID:9278 |
Hypervitaminosis D | contraindication | 27712000 | DOID:9971 |
Guttate psoriasis | contraindication | 37042000 | |
Immunosuppression | contraindication | 38013005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Cerebral malaria | contraindication | 53622003 | DOID:14069 |
Tuberculosis | contraindication | 56717001 | |
Congenital hyperammonemia, type I | contraindication | 62522004 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Psychotic disorder | contraindication | 69322001 | |
Disorder of calcium metabolism | contraindication | 71638002 | DOID:10575 |
Hypercalciuria | contraindication | 71938000 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Hypopituitarism | contraindication | 74728003 | DOID:9406 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Ornithine Carbamyltransferase Deficiency | contraindication | 80908008 | DOID:9271 |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Muscle atrophy | contraindication | 88092000 | DOID:767 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Bilateral cataracts | contraindication | 95722004 | |
Seizure disorder | contraindication | 128613002 | |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Pustular psoriasis | contraindication | 200973000 | |
Anastomosis of intestine | contraindication | 235407009 | |
Telangiectasia disorder | contraindication | 247479008 | |
Edema | contraindication | 267038008 | |
Pathological fracture | contraindication | 268029009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Cerebral trauma | contraindication | 275382005 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Osteopenia | contraindication | 312894000 | |
Avascular necrosis of bone | contraindication | 397758007 | DOID:10159 |
Citrullinemia | contraindication | 398680004 | DOID:9273 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Traumatic rupture of tendon | contraindication | 415749005 | |
Exposure to varicella | contraindication | 444453009 | |
Arginosuccinate Lyase Deficiency | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.06 | acidic |
pKa2 | 12.45 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | IC50 | 8.07 | WOMBAT-PK | CHEMBL | |||
Annexin A1 | Cytosolic other | WOMBAT-PK |
ID | Source |
---|---|
4018644 | VUID |
N0000146957 | NUI |
D00244 | KEGG_DRUG |
1514 | RXNORM |
C0005308 | UMLSCUI |
CHEBI:3077 | CHEBI |
CHEMBL632 | ChEMBL_ID |
D001623 | MESH_DESCRIPTOR_UI |
DB00443 | DRUGBANK_ID |
7061 | IUPHAR_LIGAND_ID |
1045 | INN_ID |
9842X06Q6M | UNII |
9782 | PUBCHEM_CID |
10006 | MMSL |
4270 | MMSL |
d00628 | MMSL |
116571008 | SNOMEDCT_US |
29896003 | SNOMEDCT_US |
4018644 | VANDF |
002168 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
DR. THROWERS BETA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69299-202 | OINTMENT | 0.05 g | TOPICAL | unapproved drug other | 4 sections |