practolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 3486 | 6673-35-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A beta-1 adrenergic antagonist that has been used in the emergency treatment of CARDIAC ARRYTHMIAS.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | g | O |
| 20 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| CL (Clearance) | 2.28 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.93 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 12.20 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 0.49 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07AB01 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, selective |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D058671 | Adrenergic beta-1 Receptor Antagonists |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| CHEBI has role | CHEBI:35530 | beta-adrenergic blockers |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 6.80 | IUPHAR | IUPHAR | |||
| Beta-2 adrenergic receptor | GPCR | Kd | 5.80 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Kd | 4.69 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 6.47 | CHEMBL | |||||
| Beta-1 adrenergic receptor | GPCR | Kd | 6.98 | CHEMBL | |||||
| Beta-2 adrenergic receptor | GPCR | Ki | 4.87 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166900 | NUI |
| D05587 | KEGG_DRUG |
| C0032896 | UMLSCUI |
| CHEBI:258351 | CHEBI |
| CHEMBL6995 | ChEMBL_ID |
| DB01297 | DRUGBANK_ID |
| D011217 | MESH_DESCRIPTOR_UI |
| 4883 | PUBCHEM_CID |
| 555 | IUPHAR_LIGAND_ID |
| 2832 | INN_ID |
| SUG9176GRW | UNII |
| 386156 | RXNORM |
| 003757 | NDDF |
| 387436006 | SNOMEDCT_US |
| 76390000 | SNOMEDCT_US |
Pharmaceutical products:
None