All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

podophyllotoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3481	518-28-5

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: podophyllotoxin podofilox condyline

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. Molecular weight: 414.41 Formula: C22H22O8 CLOGP: 2.12 LIPINSKI: 0 HAC: 8 HDO: 1 TPSA: 92.68 ALOGS: -3.56 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 13, 1990	FDA	ACTAVIS LABS UT INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D06BB04	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Antivirals
FDA PE	N0000008732	Decreased Mitosis
MeSH PA	D050256	Antimitotic Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000972	Antineoplastic Agents, Phytogenic
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D007641	Keratolytic Agents
MeSH PA	D050257	Tubulin Modulators
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50176	keratolytic drugs
CHEBI has role	CHEBI:60832	tubulin modulators
CHEBI has role	CHEBI:61951	microtubule destabilizing role
CHEBI has role	CHEBI:64911	mitotic inhibitor
CHEBI has role	CHEBI:76924	plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Condyloma acuminatum	indication	240542006	DOID:11168
Pregnancy, function	contraindication	289908002

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.37	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	6.22		DRUG MATRIX
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		IC50	7.85		CHEMBL
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	5.40		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.30		DRUG MATRIX
Tubulin	Structural	P04350 P07437 P68363 P68366 P68371 Q13509 Q13748 Q13885 Q3ZCM7 Q6PEY2 Q71U36 Q9BQE3 Q9BUF5 Q9BVA1 Q9H4B7	TBB4A_HUMAN TBB5_HUMAN TBA1B_HUMAN TBA4A_HUMAN TBB4B_HUMAN TBB3_HUMAN TBA3C_HUMAN TBB2A_HUMAN TBB8_HUMAN TBA3E_HUMAN TBA1A_HUMAN TBA1C_HUMAN TBB6_HUMAN TBB2B_HUMAN TBB1_HUMAN		IC50	6		CHEMBL
Regulatory protein E2	Unclassified		VE2_HPV11		Kd	4.70		CHEMBL
Tubulin alpha-1A chain	Structural		TBA1A_PIG		IC50	6.34		CHEMBL
Regulatory protein E2	Unclassified		VE2_HPV1A		Kd	5.98		CHEMBL
Tubulin	Structural		TBB2B_BOVIN Q862F3_BOVIN Q862L2_BOVIN		IC50	6.34		CHEMBL
Tubulin	Structural		TBA1A_PIG TBB_PIG		Ki	5.66		CHEMBL
Human papillomavirus regulatory protein E2	Unclassified		VE2_HPV16		Kd	4.15		CHEMBL

External reference:

ID	Source
4019583	VUID
N0000147681	NUI
D05529	KEGG_DRUG
4019583	VANDF
C0032334	UMLSCUI
CHEBI:50305	CHEBI
POD	PDB_CHEM_ID
CHEMBL61	ChEMBL_ID
D011034	MESH_DESCRIPTOR_UI
DB01179	DRUGBANK_ID
10607	PUBCHEM_CID
225782	RXNORM
5312	MMSL
003584	NDDF
415128000	SNOMEDCT_US
76575003	SNOMEDCT_US
L36H50F353	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Condylox	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6118	GEL	5 mg	TOPICAL	NDA	23 sections
Condylox	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6118	GEL	5 mg	TOPICAL	NDA	23 sections
PODOFILOX	HUMAN PRESCRIPTION DRUG LABEL	1	0574-0611	SOLUTION	5 mg	TOPICAL	ANDA	24 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3204	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3204	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	0591-3204	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6198	SOLUTION	5 mg	TOPICAL	NDA authorized generic	20 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8832	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8832	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	63629-8832	SOLUTION	5 mg	TOPICAL	NDA authorized generic	23 sections