oxybenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3412 131-57-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzophenone-3
  • oxybenzone
  • oxybenzon
  • Molecular weight: 228.25
  • Formula: C14H12O3
  • CLOGP: 3.59
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.25
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 439.42 19.25 114 3092 14274 50587644
Therapy interrupted 304.10 19.25 92 3114 20060 50581858
Death 181.20 19.25 155 3051 325224 50276694
Therapy cessation 161.50 19.25 61 3145 25950 50575968
Squamous cell carcinoma of skin 128.97 19.25 35 3171 5143 50596775
Hospitalisation 84.75 19.25 53 3153 67884 50534034
Surgery 83.74 19.25 40 3166 30165 50571753
Skin atrophy 75.24 19.25 22 3184 4223 50597695
Neoplasm skin 61.12 19.25 14 3192 1026 50600892
Ochronosis 49.82 19.25 7 3199 26 50601892
Drug ineffective 48.03 19.25 136 3070 819197 49782721
Intentional dose omission 39.25 19.25 14 3192 5036 50596882
Jarisch-Herxheimer reaction 22.97 19.25 5 3201 290 50601628
Chronic sinusitis 22.86 19.25 10 3196 6135 50595783
Paraesthesia oral 21.68 19.25 12 3194 12209 50589709
Dermatophytosis 19.92 19.25 4 3202 156 50601762
Spinal operation 19.51 19.25 9 3197 6251 50595667
COVID-19 19.35 19.25 19 3187 46643 50555275

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 277.22 27.43 184 1319 341900 29231124
Therapy interrupted 179.94 27.43 48 1455 8338 29564686
Therapy cessation 117.12 27.43 39 1464 14423 29558601
Surgery 76.67 27.43 27 1476 11752 29561272
Hospitalisation 49.16 27.43 30 1473 45958 29527066

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 494.70 18.62 136 4212 19900 64474484
Death 475.13 18.62 329 4019 482376 64012008
Therapy cessation 273.93 18.62 97 4251 32392 64461992
Surgery 166.91 18.62 65 4283 28148 64466236
Hospitalisation 146.42 18.62 80 4268 75127 64419257
Squamous cell carcinoma of skin 98.16 18.62 35 4313 11841 64482543
Skin atrophy 74.89 18.62 23 4325 4897 64489487
Neoplasm skin 58.29 18.62 14 4334 1183 64493201
Intentional dose omission 47.98 18.62 17 4331 5635 64488749
Ochronosis 47.06 18.62 7 4341 39 64494345
Spinal operation 35.75 18.62 14 4334 6119 64488265
COVID-19 32.12 18.62 30 4318 65110 64429274
Macular degeneration 26.28 18.62 11 4337 5699 64488685
Knee operation 25.15 18.62 10 4338 4547 64489837
Condition aggravated 20.23 18.62 63 4285 372363 64122021
Chronic sinusitis 18.93 18.62 9 4339 6283 64488101
Pneumonia 18.84 18.62 81 4267 559495 63934889

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:73335 ultraviolet filters
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Hormone-sensitive lipase Enzyme IC50 5.49 CHEMBL

External reference:

IDSource
4019544 VUID
N0000147648 NUI
D05309 KEGG_DRUG
4019323 VANDF
4019544 VANDF
C0069803 UMLSCUI
CHEBI:34283 CHEBI
CHEMBL1625 ChEMBL_ID
DB01428 DRUGBANK_ID
4632 PUBCHEM_CID
2096 INN_ID
C005290 MESH_SUPPLEMENTAL_RECORD_UI
95OOS7VE0Y UNII
32673 RXNORM
NOCODE MMSL
001967 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 30 mg TOPICAL OTC monograph not final 9 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 30.60 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 30.60 mg TOPICAL OTC monograph not final 8 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 2 g TOPICAL OTC monograph not final 12 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0936 STICK 30 mg TOPICAL OTC monograph not final 11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0937 LOTION 60 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 30 mg TOPICAL OTC monograph not final 13 sections
Walgreens Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-0956 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 55 Dry Touch HUMAN OTC DRUG LABEL 5 0363-0963 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Clear Complexion For Face HUMAN OTC DRUG LABEL 5 0363-0981 LOTION 45 mg TOPICAL OTC monograph not final 11 sections
Walgreens Sport SPF 30 HUMAN OTC DRUG LABEL 5 0363-0991 SPRAY 40 mg TOPICAL OTC monograph not final 13 sections
Well at Walgreens Kids Sunscreen Broad Spectrum SPF 50 HUMAN OTC DRUG LABEL 5 0363-0992 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Well at Walgreens Mist Sheer Broad Spectrum Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 5 0363-0996 SPRAY 500 mg TOPICAL OTC monograph not final 13 sections
Scar with SPF 30Walgreens HUMAN OTC DRUG LABEL 3 0363-1116 CREAM 6 g TOPICAL OTC monograph final 9 sections
70 Dry Touch SPF 70 HUMAN OTC DRUG LABEL 5 0363-1125 STICK 3 g TOPICAL OTC monograph not final 8 sections
Walgreens Sunscreen Sport SFP 70 HUMAN OTC DRUG LABEL 5 0363-1671 LOTION 6 g TOPICAL OTC monograph not final 13 sections
Walgreens Scar Cream w/SPF 30 HUMAN OTC DRUG LABEL 3 0363-2054 CREAM 60 mg TOPICAL OTC monograph final 12 sections
Walgreen Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-2720 LOTION 6 g TOPICAL OTC monograph not final 13 sections
SPF 55 Sport SunstickWell at Walgreens HUMAN OTC DRUG LABEL 5 0363-3215 STICK 6 g TOPICAL OTC monograph not final 10 sections
Walgreens Sport Faces SPF 30 HUMAN OTC DRUG LABEL 5 0363-3890 LOTION 4 g TOPICAL OTC monograph not final 13 sections