oxybenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3412 131-57-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzophenone-3
  • oxybenzone
  • oxybenzon
  • Molecular weight: 228.25
  • Formula: C14H12O3
  • CLOGP: 3.59
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.25
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 824.03 21.59 224 5359 24152 63459287
Chronic sinusitis 254.00 21.59 78 5505 12765 63470674
Therapy interrupted 234.59 21.59 93 5490 32362 63451077
Paraesthesia oral 222.96 21.59 78 5505 19178 63464261
Procedural pain 210.59 21.59 77 5506 21492 63461947
Therapy cessation 132.65 21.59 61 5522 30396 63453043
Vaginal flatulence 123.67 21.59 33 5550 3260 63480179
Death 119.42 21.59 155 5428 374226 63109213
Therapeutic product effect incomplete 117.16 21.59 93 5490 124963 63358476
Drug ineffective 112.54 21.59 267 5316 1044498 62438941
Squamous cell carcinoma of skin 111.70 21.59 35 5548 6097 63477342
Proctitis 107.29 21.59 33 5550 5408 63478031
Female genital tract fistula 104.50 21.59 35 5548 7524 63475915
Dyspepsia 104.34 21.59 80 5503 102116 63381323
Radiculopathy 92.41 21.59 33 5550 8578 63474861
Vaginal discharge 90.29 21.59 33 5550 9165 63474274
Colitis ulcerative 71.08 21.59 38 5545 26053 63457386
Surgery 67.40 21.59 41 5542 35871 63447568
Skin atrophy 64.97 21.59 22 5561 4884 63478555
Hospitalisation 64.42 21.59 56 5527 85025 63398414
Frequent bowel movements 64.03 21.59 34 5549 22988 63460451
Oral candidiasis 61.52 21.59 33 5550 22765 63460674
Weight decreased 56.43 21.59 93 5490 276705 63206734
Rectal haemorrhage 51.31 21.59 39 5544 48991 63434448
Neoplasm skin 50.90 21.59 14 5569 1547 63481892
Pyrexia 48.64 21.59 119 5464 470359 63013080
Colitis 47.28 21.59 37 5546 48491 63434948
Ochronosis 45.05 21.59 7 5576 40 63483399
Infusion related reaction 44.07 21.59 78 5505 245443 63237996
Haematochezia 42.03 21.59 36 5547 53508 63429931
Malaise 28.79 21.59 91 5492 415863 63067576
Intentional dose omission 28.47 21.59 14 5569 8061 63475378
Constipation 22.18 21.59 56 5527 224887 63258552

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 209.12 25.51 186 2134 397863 34556748
Therapy interrupted 147.78 25.51 49 2271 13648 34940963
Therapy cessation 100.67 25.51 39 2281 16934 34937677
Anal inflammation 89.09 25.51 20 2300 1280 34953331
SARS-CoV-2 test negative 77.07 25.51 17 2303 1003 34953608
Accident 66.33 25.51 21 2299 5026 34949585
Surgery 64.76 25.51 27 2293 14130 34940481
Proctalgia 59.74 25.51 20 2300 5703 34948908
Haemorrhoids 41.63 25.51 20 2300 14555 34940056
Body temperature increased 38.30 25.51 20 2300 17348 34937263
Hospitalisation 38.20 25.51 31 2289 56871 34897740
Appendicolith 34.65 25.51 15 2305 8586 34946025
Appendicitis 26.91 25.51 15 2305 14792 34939819
Ventricular fibrillation 25.58 25.51 17 2303 22937 34931674

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 400.70 19.75 138 7159 31203 79705888
Death 339.96 19.75 331 6966 566183 79170908
Macular degeneration 243.45 19.75 74 7223 11222 79725869
Chronic sinusitis 237.21 19.75 75 7222 12951 79724140
Therapy cessation 231.03 19.75 97 7200 37465 79699626
Paraesthesia oral 203.98 19.75 75 7222 20396 79716695
Procedural pain 195.21 19.75 75 7222 23009 79714082
Surgery 141.32 19.75 66 7231 32700 79704391
Vaginal flatulence 125.47 19.75 32 7265 2543 79734548
Hospitalisation 113.95 19.75 83 7214 94153 79642938
Female genital tract fistula 107.05 19.75 34 7263 5941 79731150
Therapeutic product effect incomplete 105.66 19.75 94 7203 141551 79595540
Proctitis 96.52 19.75 32 7265 6400 79730691
Vaginal discharge 91.86 19.75 32 7265 7431 79729660
Dyspepsia 90.85 19.75 77 7220 108610 79628481
Radiculopathy 86.62 19.75 32 7265 8792 79728299
Squamous cell carcinoma of skin 82.05 19.75 35 7262 13998 79723093
Anal inflammation 75.74 19.75 19 7278 1411 79735680
Skin atrophy 64.57 19.75 23 7274 5695 79731396
SARS-CoV-2 test negative 61.72 19.75 16 7281 1355 79735736
Colitis ulcerative 59.54 19.75 38 7259 34704 79702387
Frequent bowel movements 54.86 19.75 34 7263 29505 79707586
Neoplasm skin 49.91 19.75 14 7283 1597 79735494
Oral candidiasis 49.76 19.75 32 7265 29596 79707495
Pyrexia 49.47 19.75 155 7142 678554 79058537
Infusion related reaction 46.71 19.75 79 7218 230158 79506933
Accident 45.01 19.75 20 7277 8811 79728280
Weight decreased 44.08 19.75 99 7198 355099 79381992
Proctalgia 42.63 19.75 20 7277 9981 79727110
Ochronosis 42.61 19.75 7 7290 57 79737034
Rectal haemorrhage 38.64 19.75 41 7256 76259 79660832
Malaise 38.51 19.75 115 7182 489754 79247337
Intentional dose omission 35.64 19.75 17 7280 8800 79728291
Pain 34.30 19.75 141 7156 703661 79033430
Constipation 34.08 19.75 78 7219 282972 79454119
Colitis 32.95 19.75 37 7260 73270 79663821
Appendicolith 30.10 19.75 15 7282 8536 79728555
Spinal operation 28.20 19.75 14 7283 7903 79729188
Haematochezia 27.65 19.75 37 7260 87608 79649483
Drug interaction 22.93 19.75 5 7292 415178 79321913
Haemorrhoids 21.00 19.75 19 7278 29109 79707982
Knee operation 19.79 19.75 10 7287 5856 79731235

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:73335 ultraviolet filters
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Hormone-sensitive lipase Enzyme IC50 5.49 CHEMBL

External reference:

IDSource
4019544 VUID
N0000147648 NUI
D05309 KEGG_DRUG
4019323 VANDF
4019544 VANDF
C0069803 UMLSCUI
CHEBI:34283 CHEBI
CHEMBL1625 ChEMBL_ID
DB01428 DRUGBANK_ID
4632 PUBCHEM_CID
C005290 MESH_SUPPLEMENTAL_RECORD_UI
2096 INN_ID
95OOS7VE0Y UNII
32673 RXNORM
NOCODE MMSL
001967 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 30 mg TOPICAL OTC monograph not final 9 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 30.60 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 30.60 mg TOPICAL OTC monograph not final 8 sections
Walgreens SPF 50 Sport Faces HUMAN OTC DRUG LABEL 5 0363-0087 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS 100 DRY TOUCH BROAD SPECTRUM SPF 100 FACE SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0232 LOTION 60 mg TOPICAL OTC monograph final 12 sections
Walgreens 90 Sport Continuous HUMAN OTC DRUG LABEL 5 0363-0249 SPRAY 60 mg TOPICAL OTC monograph final 12 sections
Walgreens Oil-Free Moisturizing Broad Spectrum SPF 15 Sunscreen HUMAN OTC DRUG LABEL 4 0363-0265 LOTION 40 mg TOPICAL OTC monograph final 12 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 2 g TOPICAL OTC monograph not final 12 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0936 STICK 30 mg TOPICAL OTC monograph not final 11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0937 LOTION 60 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 30 mg TOPICAL OTC monograph not final 13 sections
Walgreens Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-0956 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 55 Dry Touch HUMAN OTC DRUG LABEL 5 0363-0963 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Clear Complexion For Face HUMAN OTC DRUG LABEL 5 0363-0981 LOTION 45 mg TOPICAL OTC monograph not final 11 sections
Walgreens Sport SPF 30 HUMAN OTC DRUG LABEL 5 0363-0991 SPRAY 40 mg TOPICAL OTC monograph not final 13 sections
Well at Walgreens Kids Sunscreen Broad Spectrum SPF 50 HUMAN OTC DRUG LABEL 5 0363-0992 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Well at Walgreens Mist Sheer Broad Spectrum Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 5 0363-0996 SPRAY 500 mg TOPICAL OTC monograph not final 13 sections