Stem definition | Drug id | CAS RN |
---|---|---|
3412 | 131-57-7 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 7, 1992 | FDA | BAYER HEALTHCARE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Macular degeneration | 628.67 | 19.63 | 165 | 3952 | 18743 | 56269207 |
Therapy interrupted | 273.01 | 19.63 | 93 | 4024 | 25532 | 56262418 |
Death | 155.05 | 19.63 | 155 | 3962 | 341271 | 55946679 |
Therapy cessation | 150.08 | 19.63 | 61 | 4056 | 27203 | 56260747 |
Squamous cell carcinoma of skin | 122.48 | 19.63 | 35 | 4082 | 5367 | 56282583 |
Chronic sinusitis | 111.41 | 19.63 | 36 | 4081 | 8342 | 56279608 |
Paraesthesia oral | 88.70 | 19.63 | 35 | 4082 | 14414 | 56273536 |
Drug ineffective | 87.51 | 19.63 | 200 | 3917 | 918789 | 55369161 |
Procedural pain | 81.30 | 19.63 | 34 | 4083 | 16237 | 56271713 |
Surgery | 78.33 | 19.63 | 41 | 4076 | 32445 | 56255505 |
Hospitalisation | 77.58 | 19.63 | 55 | 4062 | 74945 | 56213005 |
Skin atrophy | 70.70 | 19.63 | 22 | 4095 | 4508 | 56283442 |
Neoplasm skin | 57.43 | 19.63 | 14 | 4103 | 1160 | 56286790 |
Ochronosis | 53.54 | 19.63 | 8 | 4109 | 42 | 56287908 |
Therapeutic product effect incomplete | 47.45 | 19.63 | 48 | 4069 | 105983 | 56181967 |
Dyspepsia | 37.71 | 19.63 | 38 | 4079 | 83433 | 56204517 |
Intentional dose omission | 34.69 | 19.63 | 14 | 4103 | 6096 | 56281854 |
Anal injury | 22.22 | 19.63 | 4 | 4113 | 74 | 56287876 |
Jarisch-Herxheimer reaction | 21.85 | 19.63 | 5 | 4112 | 315 | 56287635 |
Pyrexia | 21.25 | 19.63 | 73 | 4044 | 418700 | 55869250 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Death | 246.62 | 26.22 | 186 | 1679 | 360383 | 31335096 |
Therapy interrupted | 166.11 | 26.22 | 49 | 1816 | 10547 | 31684932 |
Therapy cessation | 109.89 | 26.22 | 39 | 1826 | 15016 | 31680463 |
Surgery | 71.00 | 26.22 | 27 | 1838 | 12572 | 31682907 |
Hospitalisation | 42.91 | 26.22 | 30 | 1835 | 49777 | 31645702 |
Appendicolith | 42.32 | 26.22 | 15 | 1850 | 5716 | 31689763 |
Appendicitis | 32.26 | 26.22 | 15 | 1850 | 11450 | 31684029 |
Ventricular fibrillation | 30.58 | 26.22 | 17 | 1848 | 18831 | 31676648 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Therapy interrupted | 455.41 | 18.96 | 138 | 5359 | 24664 | 70898283 |
Death | 419.85 | 18.96 | 331 | 5166 | 509730 | 70413217 |
Therapy cessation | 257.12 | 18.96 | 97 | 5400 | 33579 | 70889368 |
Surgery | 157.55 | 18.96 | 66 | 5431 | 29923 | 70893024 |
Hospitalisation | 134.07 | 18.96 | 82 | 5415 | 82486 | 70840461 |
Chronic sinusitis | 101.04 | 18.96 | 34 | 5463 | 8417 | 70914530 |
Macular degeneration | 100.85 | 18.96 | 33 | 5464 | 7495 | 70915452 |
Squamous cell carcinoma of skin | 91.05 | 18.96 | 35 | 5462 | 12677 | 70910270 |
Paraesthesia oral | 77.80 | 18.96 | 33 | 5464 | 15384 | 70907563 |
Procedural pain | 72.87 | 18.96 | 33 | 5464 | 17976 | 70904971 |
Skin atrophy | 70.56 | 18.96 | 23 | 5474 | 5156 | 70917791 |
Neoplasm skin | 54.86 | 18.96 | 14 | 5483 | 1318 | 70921629 |
Ochronosis | 51.48 | 18.96 | 8 | 5489 | 53 | 70922894 |
Therapeutic product effect incomplete | 43.59 | 18.96 | 50 | 5447 | 119832 | 70803115 |
Intentional dose omission | 42.27 | 18.96 | 17 | 5480 | 6924 | 70916023 |
Appendicolith | 38.39 | 18.96 | 15 | 5482 | 5665 | 70917282 |
Spinal operation | 32.01 | 18.96 | 14 | 5483 | 7014 | 70915933 |
Dyspepsia | 30.43 | 18.96 | 36 | 5461 | 89041 | 70833906 |
Appendicitis | 23.04 | 18.96 | 15 | 5482 | 16718 | 70906229 |
Knee operation | 22.81 | 18.96 | 10 | 5487 | 5037 | 70917910 |
Anal injury | 20.73 | 18.96 | 4 | 5493 | 103 | 70922844 |
Ventricular fibrillation | 20.66 | 18.96 | 17 | 5480 | 27094 | 70895853 |
None
Source | Code | Description |
---|---|---|
MeSH PA | D003358 | Cosmetics |
MeSH PA | D003879 | Dermatologic Agents |
MeSH PA | D020011 | Protective Agents |
MeSH PA | D011837 | Radiation-Protective Agents |
MeSH PA | D013473 | Sunscreening Agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50177 | dermatologic agent |
CHEBI has role | CHEBI:50267 | protective agents |
CHEBI has role | CHEBI:73335 | ultraviolet filters |
CHEBI has role | CHEBI:78298 | environmental contaminants |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.31 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Hormone-sensitive lipase | Enzyme | IC50 | 5.49 | CHEMBL |
ID | Source |
---|---|
4019544 | VUID |
N0000147648 | NUI |
D05309 | KEGG_DRUG |
4019323 | VANDF |
4019544 | VANDF |
C0069803 | UMLSCUI |
CHEBI:34283 | CHEBI |
CHEMBL1625 | ChEMBL_ID |
DB01428 | DRUGBANK_ID |
4632 | PUBCHEM_CID |
C005290 | MESH_SUPPLEMENTAL_RECORD_UI |
2096 | INN_ID |
95OOS7VE0Y | UNII |
32673 | RXNORM |
NOCODE | MMSL |
001967 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Solbar Avo SPF35 | HUMAN OTC DRUG LABEL | 4 | 0096-0687 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Solbar Avo SPF35 | HUMAN OTC DRUG LABEL | 4 | 0096-0687 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.06 g | TOPICAL | OTC monograph final | 8 sections |
Purpose | HUMAN OTC DRUG LABEL | 3 | 0187-5500 | LOTION | 30 mg | TOPICAL | OTC monograph not final | 9 sections |
Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 60 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 60 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 60 mg | TOPICAL | OTC monograph final | 11 sections |
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 60 mg | TOPICAL | OTC monograph final | 11 sections |
Almay Anti Aging Lip Care SPF 20 | HUMAN OTC DRUG LABEL | 5 | 0311-0709 | LIPSTICK | 5 mg | TOPICAL | OTC monograph final | 8 sections |
Blue Lizard Regular | HUMAN OTC DRUG LABEL | 4 | 0316-2010 | LOTION | 30.60 mg | TOPICAL | OTC monograph final | 8 sections |
Blue Lizard Sport Original Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0316-2019 | LOTION | 30.60 mg | TOPICAL | OTC monograph not final | 8 sections |
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0696 | CREAM | 2 g | TOPICAL | OTC monograph not final | 12 sections |
WALGREEN SPORT SPF 70 SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0900 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 12 sections |
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0933 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 12 sections |
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0936 | STICK | 30 mg | TOPICAL | OTC monograph not final | 11 sections |
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0937 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 13 sections |
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN | HUMAN OTC DRUG LABEL | 5 | 0363-0940 | LOTION | 30 mg | TOPICAL | OTC monograph not final | 13 sections |
Walgreens Sport SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0363-0956 | SPRAY | 50 mg | TOPICAL | OTC monograph not final | 12 sections |
Walgreens SPF 55 Dry Touch | HUMAN OTC DRUG LABEL | 5 | 0363-0963 | LOTION | 60 mg | TOPICAL | OTC monograph not final | 12 sections |
Walgreens SPF 50 Clear Complexion For Face | HUMAN OTC DRUG LABEL | 5 | 0363-0981 | LOTION | 45 mg | TOPICAL | OTC monograph not final | 11 sections |
Walgreens Sport SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0363-0991 | SPRAY | 40 mg | TOPICAL | OTC monograph not final | 13 sections |
Well at Walgreens Kids Sunscreen Broad Spectrum SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0363-0992 | SPRAY | 50 mg | TOPICAL | OTC monograph not final | 12 sections |
Well at Walgreens Mist Sheer Broad Spectrum Broad Spectrum SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0363-0996 | SPRAY | 500 mg | TOPICAL | OTC monograph not final | 13 sections |
Scar with SPF 30Walgreens | HUMAN OTC DRUG LABEL | 3 | 0363-1116 | CREAM | 6 g | TOPICAL | OTC monograph final | 9 sections |
70 Dry Touch SPF 70 | HUMAN OTC DRUG LABEL | 5 | 0363-1125 | STICK | 3 g | TOPICAL | OTC monograph not final | 8 sections |
Walgreens Sunscreen Sport SFP 70 | HUMAN OTC DRUG LABEL | 5 | 0363-1671 | LOTION | 6 g | TOPICAL | OTC monograph not final | 13 sections |
Walgreens Scar Cream w/SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0363-2054 | CREAM | 60 mg | TOPICAL | OTC monograph final | 12 sections |