oxybenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3412	131-57-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzophenone-3 oxybenzone oxybenzon	Molecular weight: 228.25 Formula: C14H12O3 CLOGP: 3.59 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 46.53 ALOGS: -3.25 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzophenone-3
oxybenzone
oxybenzon

Molecular weight: 228.25
Formula: C14H12O3
CLOGP: 3.59
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -3.25
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	824.03	21.59	224	5359	24152	63459287
Chronic sinusitis	254.00	21.59	78	5505	12765	63470674
Therapy interrupted	234.59	21.59	93	5490	32362	63451077
Paraesthesia oral	222.96	21.59	78	5505	19178	63464261
Procedural pain	210.59	21.59	77	5506	21492	63461947
Therapy cessation	132.65	21.59	61	5522	30396	63453043
Vaginal flatulence	123.67	21.59	33	5550	3260	63480179
Death	119.42	21.59	155	5428	374226	63109213
Therapeutic product effect incomplete	117.16	21.59	93	5490	124963	63358476
Drug ineffective	112.54	21.59	267	5316	1044498	62438941
Squamous cell carcinoma of skin	111.70	21.59	35	5548	6097	63477342
Proctitis	107.29	21.59	33	5550	5408	63478031
Female genital tract fistula	104.50	21.59	35	5548	7524	63475915
Dyspepsia	104.34	21.59	80	5503	102116	63381323
Radiculopathy	92.41	21.59	33	5550	8578	63474861
Vaginal discharge	90.29	21.59	33	5550	9165	63474274
Colitis ulcerative	71.08	21.59	38	5545	26053	63457386
Surgery	67.40	21.59	41	5542	35871	63447568
Skin atrophy	64.97	21.59	22	5561	4884	63478555
Hospitalisation	64.42	21.59	56	5527	85025	63398414
Frequent bowel movements	64.03	21.59	34	5549	22988	63460451
Oral candidiasis	61.52	21.59	33	5550	22765	63460674
Weight decreased	56.43	21.59	93	5490	276705	63206734
Rectal haemorrhage	51.31	21.59	39	5544	48991	63434448
Neoplasm skin	50.90	21.59	14	5569	1547	63481892
Pyrexia	48.64	21.59	119	5464	470359	63013080
Colitis	47.28	21.59	37	5546	48491	63434948
Ochronosis	45.05	21.59	7	5576	40	63483399
Infusion related reaction	44.07	21.59	78	5505	245443	63237996
Haematochezia	42.03	21.59	36	5547	53508	63429931
Malaise	28.79	21.59	91	5492	415863	63067576
Intentional dose omission	28.47	21.59	14	5569	8061	63475378
Constipation	22.18	21.59	56	5527	224887	63258552

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	209.12	25.51	186	2134	397863	34556748
Therapy interrupted	147.78	25.51	49	2271	13648	34940963
Therapy cessation	100.67	25.51	39	2281	16934	34937677
Anal inflammation	89.09	25.51	20	2300	1280	34953331
SARS-CoV-2 test negative	77.07	25.51	17	2303	1003	34953608
Accident	66.33	25.51	21	2299	5026	34949585
Surgery	64.76	25.51	27	2293	14130	34940481
Proctalgia	59.74	25.51	20	2300	5703	34948908
Haemorrhoids	41.63	25.51	20	2300	14555	34940056
Body temperature increased	38.30	25.51	20	2300	17348	34937263
Hospitalisation	38.20	25.51	31	2289	56871	34897740
Appendicolith	34.65	25.51	15	2305	8586	34946025
Appendicitis	26.91	25.51	15	2305	14792	34939819
Ventricular fibrillation	25.58	25.51	17	2303	22937	34931674

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	400.70	19.75	138	7159	31203	79705888
Death	339.96	19.75	331	6966	566183	79170908
Macular degeneration	243.45	19.75	74	7223	11222	79725869
Chronic sinusitis	237.21	19.75	75	7222	12951	79724140
Therapy cessation	231.03	19.75	97	7200	37465	79699626
Paraesthesia oral	203.98	19.75	75	7222	20396	79716695
Procedural pain	195.21	19.75	75	7222	23009	79714082
Surgery	141.32	19.75	66	7231	32700	79704391
Vaginal flatulence	125.47	19.75	32	7265	2543	79734548
Hospitalisation	113.95	19.75	83	7214	94153	79642938
Female genital tract fistula	107.05	19.75	34	7263	5941	79731150
Therapeutic product effect incomplete	105.66	19.75	94	7203	141551	79595540
Proctitis	96.52	19.75	32	7265	6400	79730691
Vaginal discharge	91.86	19.75	32	7265	7431	79729660
Dyspepsia	90.85	19.75	77	7220	108610	79628481
Radiculopathy	86.62	19.75	32	7265	8792	79728299
Squamous cell carcinoma of skin	82.05	19.75	35	7262	13998	79723093
Anal inflammation	75.74	19.75	19	7278	1411	79735680
Skin atrophy	64.57	19.75	23	7274	5695	79731396
SARS-CoV-2 test negative	61.72	19.75	16	7281	1355	79735736
Colitis ulcerative	59.54	19.75	38	7259	34704	79702387
Frequent bowel movements	54.86	19.75	34	7263	29505	79707586
Neoplasm skin	49.91	19.75	14	7283	1597	79735494
Oral candidiasis	49.76	19.75	32	7265	29596	79707495
Pyrexia	49.47	19.75	155	7142	678554	79058537
Infusion related reaction	46.71	19.75	79	7218	230158	79506933
Accident	45.01	19.75	20	7277	8811	79728280
Weight decreased	44.08	19.75	99	7198	355099	79381992
Proctalgia	42.63	19.75	20	7277	9981	79727110
Ochronosis	42.61	19.75	7	7290	57	79737034
Rectal haemorrhage	38.64	19.75	41	7256	76259	79660832
Malaise	38.51	19.75	115	7182	489754	79247337
Intentional dose omission	35.64	19.75	17	7280	8800	79728291
Pain	34.30	19.75	141	7156	703661	79033430
Constipation	34.08	19.75	78	7219	282972	79454119
Colitis	32.95	19.75	37	7260	73270	79663821
Appendicolith	30.10	19.75	15	7282	8536	79728555
Spinal operation	28.20	19.75	14	7283	7903	79729188
Haematochezia	27.65	19.75	37	7260	87608	79649483
Drug interaction	22.93	19.75	5	7292	415178	79321913
Haemorrhoids	21.00	19.75	19	7278	29109	79707982
Knee operation	19.79	19.75	10	7287	5856	79731235

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50177	dermatologic agent
CHEBI has role	CHEBI:50267	protective agents
CHEBI has role	CHEBI:73335	ultraviolet filters
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.31	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Hormone-sensitive lipase	Enzyme		LIPS_RAT		IC50	5.49		CHEMBL

External reference:

ID	Source
4019544	VUID
N0000147648	NUI
D05309	KEGG_DRUG
4019323	VANDF
4019544	VANDF
C0069803	UMLSCUI
CHEBI:34283	CHEBI
CHEMBL1625	ChEMBL_ID
DB01428	DRUGBANK_ID
4632	PUBCHEM_CID
C005290	MESH_SUPPLEMENTAL_RECORD_UI
2096	INN_ID
95OOS7VE0Y	UNII
32673	RXNORM
NOCODE	MMSL
001967	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Fifty SPF50	HUMAN OTC DRUG LABEL	4	0096-0741	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Purpose	HUMAN OTC DRUG LABEL	3	0187-5500	LOTION	30 mg	TOPICAL	OTC monograph not final	9 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	60 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	60 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	60 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	60 mg	TOPICAL	OTC monograph final	11 sections
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	5 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Regular	HUMAN OTC DRUG LABEL	4	0316-2010	LOTION	30.60 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Sport Original Sunscreen	HUMAN OTC DRUG LABEL	4	0316-2019	LOTION	30.60 mg	TOPICAL	OTC monograph not final	8 sections
Walgreens SPF 50 Sport Faces	HUMAN OTC DRUG LABEL	5	0363-0087	LOTION	60 mg	TOPICAL	OTC monograph not final	12 sections
WALGREENS 100 DRY TOUCH BROAD SPECTRUM SPF 100 FACE SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0232	LOTION	60 mg	TOPICAL	OTC monograph final	12 sections
Walgreens 90 Sport Continuous	HUMAN OTC DRUG LABEL	5	0363-0249	SPRAY	60 mg	TOPICAL	OTC monograph final	12 sections
Walgreens Oil-Free Moisturizing Broad Spectrum SPF 15 Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0265	LOTION	40 mg	TOPICAL	OTC monograph final	12 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen	HUMAN OTC DRUG LABEL	3	0363-0696	CREAM	2 g	TOPICAL	OTC monograph not final	12 sections
WALGREEN SPORT SPF 70 SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0900	LOTION	60 mg	TOPICAL	OTC monograph not final	12 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0933	LOTION	60 mg	TOPICAL	OTC monograph not final	12 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0936	STICK	30 mg	TOPICAL	OTC monograph not final	11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0937	LOTION	60 mg	TOPICAL	OTC monograph not final	13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0940	LOTION	30 mg	TOPICAL	OTC monograph not final	13 sections
Walgreens Sport SPF 50	HUMAN OTC DRUG LABEL	5	0363-0956	SPRAY	50 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 55 Dry Touch	HUMAN OTC DRUG LABEL	5	0363-0963	LOTION	60 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Clear Complexion For Face	HUMAN OTC DRUG LABEL	5	0363-0981	LOTION	45 mg	TOPICAL	OTC monograph not final	11 sections
Walgreens Sport SPF 30	HUMAN OTC DRUG LABEL	5	0363-0991	SPRAY	40 mg	TOPICAL	OTC monograph not final	13 sections
Well at Walgreens Kids Sunscreen Broad Spectrum SPF 50	HUMAN OTC DRUG LABEL	5	0363-0992	SPRAY	50 mg	TOPICAL	OTC monograph not final	12 sections
Well at Walgreens Mist Sheer Broad Spectrum Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	5	0363-0996	SPRAY	500 mg	TOPICAL	OTC monograph not final	13 sections