oxybenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3412	131-57-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzophenone-3 oxybenzone oxybenzon	Molecular weight: 228.25 Formula: C14H12O3 CLOGP: 3.59 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 46.53 ALOGS: -3.25 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzophenone-3
oxybenzone
oxybenzon

Molecular weight: 228.25
Formula: C14H12O3
CLOGP: 3.59
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -3.25
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 7, 1992	FDA	BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	824.03	21.59	224	5359	24152	63459287
Chronic sinusitis	254.00	21.59	78	5505	12765	63470674
Therapy interrupted	234.59	21.59	93	5490	32362	63451077
Paraesthesia oral	222.96	21.59	78	5505	19178	63464261
Procedural pain	210.59	21.59	77	5506	21492	63461947
Therapy cessation	132.65	21.59	61	5522	30396	63453043
Vaginal flatulence	123.67	21.59	33	5550	3260	63480179
Death	119.42	21.59	155	5428	374226	63109213
Therapeutic product effect incomplete	117.16	21.59	93	5490	124963	63358476
Drug ineffective	112.54	21.59	267	5316	1044498	62438941

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Death	209.12	25.51	186	2134	397863	34556748
Therapy interrupted	147.78	25.51	49	2271	13648	34940963
Therapy cessation	100.67	25.51	39	2281	16934	34937677
Anal inflammation	89.09	25.51	20	2300	1280	34953331
SARS-CoV-2 test negative	77.07	25.51	17	2303	1003	34953608
Accident	66.33	25.51	21	2299	5026	34949585
Surgery	64.76	25.51	27	2293	14130	34940481
Proctalgia	59.74	25.51	20	2300	5703	34948908
Haemorrhoids	41.63	25.51	20	2300	14555	34940056
Body temperature increased	38.30	25.51	20	2300	17348	34937263

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Therapy interrupted	400.70	19.75	138	7159	31203	79705888
Death	339.96	19.75	331	6966	566183	79170908
Macular degeneration	243.45	19.75	74	7223	11222	79725869
Chronic sinusitis	237.21	19.75	75	7222	12951	79724140
Therapy cessation	231.03	19.75	97	7200	37465	79699626
Paraesthesia oral	203.98	19.75	75	7222	20396	79716695
Procedural pain	195.21	19.75	75	7222	23009	79714082
Surgery	141.32	19.75	66	7231	32700	79704391
Vaginal flatulence	125.47	19.75	32	7265	2543	79734548
Hospitalisation	113.95	19.75	83	7214	94153	79642938

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50177	dermatologic agent
CHEBI has role	CHEBI:50267	protective agents
CHEBI has role	CHEBI:73335	ultraviolet filters
CHEBI has role	CHEBI:78298	environmental contaminants
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.31	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Hormone-sensitive lipase	Enzyme		LIPS_RAT		IC50	5.49		CHEMBL

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External reference:

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ID	Source
001967	NDDF
2096	INN_ID
32673	RXNORM
4019323	VANDF
4019544	VUID
4019544	VANDF
4632	PUBCHEM_CID
95OOS7VE0Y	UNII
C005290	MESH_SUPPLEMENTAL_RECORD_UI
C0069803	UMLSCUI

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	5 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Regular	HUMAN OTC DRUG LABEL	4	0316-2010	LOTION	30.60 mg	TOPICAL	OTC monograph final	8 sections
Blue Lizard Sport Original Sunscreen	HUMAN OTC DRUG LABEL	4	0316-2019	LOTION	30.60 mg	TOPICAL	OTC monograph not final	8 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	60 mg	TOPICAL	OTC monograph final	11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50	HUMAN OTC DRUG LABEL	5	0299-4930	LOTION	60 mg	TOPICAL	OTC monograph final	11 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	60 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Mederma	HUMAN OTC DRUG LABEL	3	0259-3192	CREAM	60 mg	TOPICAL	OTC MONOGRAPH FINAL	13 sections
Purpose	HUMAN OTC DRUG LABEL	3	0187-5500	LOTION	30 mg	TOPICAL	OTC monograph not final	9 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.06 g	TOPICAL	OTC monograph final	8 sections

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