oxybenzone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3412 131-57-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzophenone-3
  • oxybenzone
  • oxybenzon
  • Molecular weight: 228.25
  • Formula: C14H12O3
  • CLOGP: 3.59
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -3.25
  • ROTB: 3
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA BAYER HEALTHCARE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 628.67 19.63 165 3952 18743 56269207
Therapy interrupted 273.01 19.63 93 4024 25532 56262418
Death 155.05 19.63 155 3962 341271 55946679
Therapy cessation 150.08 19.63 61 4056 27203 56260747
Squamous cell carcinoma of skin 122.48 19.63 35 4082 5367 56282583
Chronic sinusitis 111.41 19.63 36 4081 8342 56279608
Paraesthesia oral 88.70 19.63 35 4082 14414 56273536
Drug ineffective 87.51 19.63 200 3917 918789 55369161
Procedural pain 81.30 19.63 34 4083 16237 56271713
Surgery 78.33 19.63 41 4076 32445 56255505
Hospitalisation 77.58 19.63 55 4062 74945 56213005
Skin atrophy 70.70 19.63 22 4095 4508 56283442
Neoplasm skin 57.43 19.63 14 4103 1160 56286790
Ochronosis 53.54 19.63 8 4109 42 56287908
Therapeutic product effect incomplete 47.45 19.63 48 4069 105983 56181967
Dyspepsia 37.71 19.63 38 4079 83433 56204517
Intentional dose omission 34.69 19.63 14 4103 6096 56281854
Anal injury 22.22 19.63 4 4113 74 56287876
Jarisch-Herxheimer reaction 21.85 19.63 5 4112 315 56287635
Pyrexia 21.25 19.63 73 4044 418700 55869250

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 246.62 26.22 186 1679 360383 31335096
Therapy interrupted 166.11 26.22 49 1816 10547 31684932
Therapy cessation 109.89 26.22 39 1826 15016 31680463
Surgery 71.00 26.22 27 1838 12572 31682907
Hospitalisation 42.91 26.22 30 1835 49777 31645702
Appendicolith 42.32 26.22 15 1850 5716 31689763
Appendicitis 32.26 26.22 15 1850 11450 31684029
Ventricular fibrillation 30.58 26.22 17 1848 18831 31676648

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Therapy interrupted 455.41 18.96 138 5359 24664 70898283
Death 419.85 18.96 331 5166 509730 70413217
Therapy cessation 257.12 18.96 97 5400 33579 70889368
Surgery 157.55 18.96 66 5431 29923 70893024
Hospitalisation 134.07 18.96 82 5415 82486 70840461
Chronic sinusitis 101.04 18.96 34 5463 8417 70914530
Macular degeneration 100.85 18.96 33 5464 7495 70915452
Squamous cell carcinoma of skin 91.05 18.96 35 5462 12677 70910270
Paraesthesia oral 77.80 18.96 33 5464 15384 70907563
Procedural pain 72.87 18.96 33 5464 17976 70904971
Skin atrophy 70.56 18.96 23 5474 5156 70917791
Neoplasm skin 54.86 18.96 14 5483 1318 70921629
Ochronosis 51.48 18.96 8 5489 53 70922894
Therapeutic product effect incomplete 43.59 18.96 50 5447 119832 70803115
Intentional dose omission 42.27 18.96 17 5480 6924 70916023
Appendicolith 38.39 18.96 15 5482 5665 70917282
Spinal operation 32.01 18.96 14 5483 7014 70915933
Dyspepsia 30.43 18.96 36 5461 89041 70833906
Appendicitis 23.04 18.96 15 5482 16718 70906229
Knee operation 22.81 18.96 10 5487 5037 70917910
Anal injury 20.73 18.96 4 5493 103 70922844
Ventricular fibrillation 20.66 18.96 17 5480 27094 70895853

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003358 Cosmetics
MeSH PA D003879 Dermatologic Agents
MeSH PA D020011 Protective Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:73335 ultraviolet filters
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Hormone-sensitive lipase Enzyme IC50 5.49 CHEMBL

External reference:

IDSource
4019544 VUID
N0000147648 NUI
D05309 KEGG_DRUG
4019323 VANDF
4019544 VANDF
C0069803 UMLSCUI
CHEBI:34283 CHEBI
CHEMBL1625 ChEMBL_ID
DB01428 DRUGBANK_ID
4632 PUBCHEM_CID
C005290 MESH_SUPPLEMENTAL_RECORD_UI
2096 INN_ID
95OOS7VE0Y UNII
32673 RXNORM
NOCODE MMSL
001967 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.06 g TOPICAL OTC monograph final 8 sections
Purpose HUMAN OTC DRUG LABEL 3 0187-5500 LOTION 30 mg TOPICAL OTC monograph not final 9 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 60 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 60 mg TOPICAL OTC monograph final 11 sections
Almay Anti Aging Lip Care SPF 20 HUMAN OTC DRUG LABEL 5 0311-0709 LIPSTICK 5 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 30.60 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 30.60 mg TOPICAL OTC monograph not final 8 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 2 g TOPICAL OTC monograph not final 12 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
WALGREENS BROAD SPECTRUM SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0936 STICK 30 mg TOPICAL OTC monograph not final 11 sections
WALGREENS SPORT BROAD SPECTRUM SPF 50 FACES SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0937 LOTION 60 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 30 DRY TOUCH SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0940 LOTION 30 mg TOPICAL OTC monograph not final 13 sections
Walgreens Sport SPF 50 HUMAN OTC DRUG LABEL 5 0363-0956 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 55 Dry Touch HUMAN OTC DRUG LABEL 5 0363-0963 LOTION 60 mg TOPICAL OTC monograph not final 12 sections
Walgreens SPF 50 Clear Complexion For Face HUMAN OTC DRUG LABEL 5 0363-0981 LOTION 45 mg TOPICAL OTC monograph not final 11 sections
Walgreens Sport SPF 30 HUMAN OTC DRUG LABEL 5 0363-0991 SPRAY 40 mg TOPICAL OTC monograph not final 13 sections
Well at Walgreens Kids Sunscreen Broad Spectrum SPF 50 HUMAN OTC DRUG LABEL 5 0363-0992 SPRAY 50 mg TOPICAL OTC monograph not final 12 sections
Well at Walgreens Mist Sheer Broad Spectrum Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 5 0363-0996 SPRAY 500 mg TOPICAL OTC monograph not final 13 sections
Scar with SPF 30Walgreens HUMAN OTC DRUG LABEL 3 0363-1116 CREAM 6 g TOPICAL OTC monograph final 9 sections
70 Dry Touch SPF 70 HUMAN OTC DRUG LABEL 5 0363-1125 STICK 3 g TOPICAL OTC monograph not final 8 sections
Walgreens Sunscreen Sport SFP 70 HUMAN OTC DRUG LABEL 5 0363-1671 LOTION 6 g TOPICAL OTC monograph not final 13 sections
Walgreens Scar Cream w/SPF 30 HUMAN OTC DRUG LABEL 3 0363-2054 CREAM 60 mg TOPICAL OTC monograph final 12 sections