Stem definition | Drug id | CAS RN |
---|---|---|
antihistaminics | 341 | 125602-71-3 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 8, 2009 | FDA | BAUSCH AND LOMB INC |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatic function abnormal | 44.10 | 29.76 | 21 | 736 | 39238 | 29534532 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatic function abnormal | 62.06 | 25.06 | 30 | 1453 | 64283 | 64432966 |
Interstitial lung disease | 42.58 | 25.06 | 27 | 1456 | 97705 | 64399544 |
Platelet count decreased | 33.58 | 25.06 | 29 | 1454 | 167682 | 64329567 |
Erythema multiforme | 30.45 | 25.06 | 12 | 1471 | 15689 | 64481560 |
Drug eruption | 29.30 | 25.06 | 15 | 1468 | 36121 | 64461128 |
Neutrophil count decreased | 27.92 | 25.06 | 19 | 1464 | 77177 | 64420072 |
None
Source | Code | Description |
---|---|---|
FDA EPC | N0000175587 | Histamine-1 Receptor Antagonist |
MeSH PA | D018926 | Anti-Allergic Agents |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:50857 | anti-allergic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.54 | acidic |
pKa2 | 9.51 | Basic |
pKa3 | 4.25 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Histamine H1 receptor | GPCR | ANTAGONIST | DRUGBANK | CHEMBL |
ID | Source |
---|---|
4029223 | VUID |
N0000181653 | NUI |
D01654 | KEGG_DRUG |
190786-44-8 | SECONDARY_CAS_RN |
658552 | RXNORM |
C2698371 | UMLSCUI |
CHEBI:71204 | CHEBI |
CHEMBL1201758 | ChEMBL_ID |
DB04890 | DRUGBANK_ID |
CHEMBL1201759 | ChEMBL_ID |
C108476 | MESH_SUPPLEMENTAL_RECORD_UI |
C511534 | MESH_SUPPLEMENTAL_RECORD_UI |
164522 | PUBCHEM_CID |
7466 | IUPHAR_LIGAND_ID |
7648 | INN_ID |
HYD2U48IAS | UNII |
167734 | MMSL |
26713 | MMSL |
347164 | MMSL |
010865 | NDDF |
010866 | NDDF |
4029223 | VANDF |
4029224 | VANDF |
443616002 | SNOMEDCT_US |
707083009 | SNOMEDCT_US |
770926005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Bepotastine Besilate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-7055 | SOLUTION/ DROPS | 15 mg | OPHTHALMIC | ANDA | 24 sections |
Bepreve | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-629 | SOLUTION/ DROPS | 15 mg | OPHTHALMIC | NDA | 21 sections |
Bepotastine Besilate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-630 | SOLUTION/ DROPS | 15 mg | OPHTHALMIC | NDA authorized generic | 22 sections |
BEPREVE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-6299 | SOLUTION/ DROPS | 15 mg | OPHTHALMIC | NDA | 21 sections |
Bepotastine Besilate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6111 | SOLUTION/ DROPS | 15 mg | OPHTHALMIC | ANDA | 22 sections |