oxiconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 3408 64211-45-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxyconazole
  • Ro 13-8996
  • oxiconazole
  • oxiconazole nitrate
  • Molecular weight: 429.12
  • Formula: C18H13Cl4N3O
  • CLOGP: 6.27
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 39.41
  • ALOGS: -5.35
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1988 FDA FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC11 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC G01AF17 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
FDA CS M0002083 Azoles
FDA EPC N0000175487 Azole Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:35441 antiinfective agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002
Tinea cruris indication 399029005
Skin irritation contraindication 367466007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.02 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 5.82 DRUG MATRIX
Cytochrome P450 3A4 Enzyme IC50 7.05 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.37 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.72 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 5.50 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.53 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.78 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.17 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.94 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.02 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 5.45 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.22 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.68 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 6.45 DRUG MATRIX
Delta-type opioid receptor GPCR Ki 5.73 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 5.33 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 5.52 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 7.40 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 6.21 DRUG MATRIX
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.55 CHEMBL
Substance-K receptor GPCR Ki 5.97 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 5.68 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme INHIBITOR CHEMBL CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.25 CHEMBL

External reference:

IDSource
4019474 VUID
N0000147594 NUI
D00885 KEGG_DRUG
64211-46-7 SECONDARY_CAS_RN
4019474 VANDF
C0069765 UMLSCUI
CHEBI:7825 CHEBI
CHEMBL1262 ChEMBL_ID
CHEMBL1200836 ChEMBL_ID
DB00239 DRUGBANK_ID
C022155 MESH_SUPPLEMENTAL_RECORD_UI
5353853 PUBCHEM_CID
4729 INN_ID
C668Q9I33J UNII
32638 RXNORM
239524 MMSL
5212 MMSL
002932 NDDF
004963 NDDF
372778004 SNOMEDCT_US
41067005 SNOMEDCT_US
57263002 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxiconazole Nitrate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0358 CREAM 10 mg TOPICAL NDA authorized generic 22 sections
Oxistat HUMAN PRESCRIPTION DRUG LABEL 1 10337-358 CREAM 10 mg TOPICAL NDA 22 sections
Oxistat HUMAN PRESCRIPTION DRUG LABEL 1 10337-359 LOTION 10 mg TOPICAL NDA 22 sections
Oxistat HUMAN PRESCRIPTION DRUG LABEL 1 21695-459 LOTION 30 mg TOPICAL NDA 22 sections
Oxiconazole Nitrate HUMAN PRESCRIPTION DRUG LABEL 1 51672-1359 CREAM 10 mg TOPICAL ANDA 25 sections