All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

oxiconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
systemic antifungal agents, miconazole derivatives	3408	64211-45-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: oxyconazole Ro 13-8996 oxiconazole oxiconazole nitrate	Molecular weight: 429.12 Formula: C18H13Cl4N3O CLOGP: 6.27 LIPINSKI: 1 HAC: 4 HDO: 0 TPSA: 39.41 ALOGS: -5.35 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 30, 1988	FDA	FOUGERA PHARMS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D01AC11	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Imidazole and triazole derivatives
ATC	G01AF17	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Imidazole derivatives
FDA CS	M0002083	Azoles
FDA EPC	N0000175487	Azole Antifungal
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
CHEBI has role	CHEBI:35441	antiinfective agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Pityriasis versicolor	indication	56454009	DOID:9060
Tinea corporis	indication	84849002
Tinea cruris	indication	399029005
Skin irritation	contraindication	367466007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.02	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.82		DRUG MATRIX
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		IC50	7.05		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.37		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.72		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	5.50		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.93		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5.53		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.78		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.17		DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.94		DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6.02		DRUG MATRIX
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		Ki	5.45		DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.22		DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.68		DRUG MATRIX
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		IC50	6		DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	6.45		DRUG MATRIX
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		Ki	5.73		DRUG MATRIX
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	5.33		DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		IC50	5.52		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	7.40		DRUG MATRIX
Thromboxane-A synthase	Enzyme	P24557	THAS_HUMAN		IC50	6.21		DRUG MATRIX
Indoleamine 2,3-dioxygenase 1	Enzyme	P14902	I23O1_HUMAN		IC50	4.55		CHEMBL
Substance-K receptor	GPCR	P21452	NK2R_HUMAN		Ki	5.97		DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	5.68		DRUG MATRIX
Lanosterol 14-alpha demethylase	Enzyme		CP51_CANAL	INHIBITOR				CHEMBL	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	5.25		CHEMBL

External reference:

ID	Source
4019474	VUID
N0000147594	NUI
D00885	KEGG_DRUG
64211-46-7	SECONDARY_CAS_RN
4019474	VANDF
C0069765	UMLSCUI
CHEBI:7825	CHEBI
CHEMBL1262	ChEMBL_ID
CHEMBL1200836	ChEMBL_ID
DB00239	DRUGBANK_ID
C022155	MESH_SUPPLEMENTAL_RECORD_UI
5353853	PUBCHEM_CID
4729	INN_ID
C668Q9I33J	UNII
32638	RXNORM
239524	MMSL
5212	MMSL
002932	NDDF
004963	NDDF
372778004	SNOMEDCT_US
41067005	SNOMEDCT_US
57263002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxiconazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0358	CREAM	10 mg	TOPICAL	NDA authorized generic	22 sections
Oxistat	HUMAN PRESCRIPTION DRUG LABEL	1	10337-358	CREAM	10 mg	TOPICAL	NDA	22 sections
Oxistat	HUMAN PRESCRIPTION DRUG LABEL	1	10337-359	LOTION	10 mg	TOPICAL	NDA	22 sections
Oxistat	HUMAN PRESCRIPTION DRUG LABEL	1	21695-459	LOTION	30 mg	TOPICAL	NDA	22 sections
Oxiconazole Nitrate	HUMAN PRESCRIPTION DRUG LABEL	1	51672-1359	CREAM	10 mg	TOPICAL	ANDA	25 sections
Oxistat	HUMAN PRESCRIPTION DRUG LABEL	1	62559-285	LOTION	10 mg	TOPICAL	NDA	23 sections