octocrylene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3395 6197-30-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octocrylene
  • octocrilene
ingredient in sunscreens and cosmetics
  • Molecular weight: 361.49
  • Formula: C24H27NO2
  • CLOGP: 6.84
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 50.09
  • ALOGS: -5.36
  • ROTB: 10

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 21, 2006 FDA LOREAL USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 456.48 21.28 115 2772 14273 50587964
Therapy interrupted 304.96 21.28 90 2797 20062 50582175
Death 197.99 21.28 156 2731 325223 50277014
Therapy cessation 164.06 21.28 60 2827 25951 50576286
Hospitalisation 89.92 21.28 53 2834 67884 50534353
Surgery 87.77 21.28 40 2847 30165 50572072
Drug ineffective 55.22 21.28 134 2753 819199 49783038
Intentional dose omission 44.61 21.28 15 2872 5035 50597202
Chronic sinusitis 23.88 21.28 10 2877 6135 50596102
Jarisch-Herxheimer reaction 23.49 21.28 5 2882 290 50601947
COVID-19 23.05 21.28 20 2867 46642 50555595
Paraesthesia oral 22.87 21.28 12 2875 12209 50590028

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 248.54 21.39 190 1721 341894 29230722
Therapy interrupted 168.37 21.39 48 1863 8338 29564278
Therapy cessation 107.84 21.39 39 1872 14423 29558193
Surgery 70.30 21.39 27 1884 11752 29560864
Hospitalisation 47.25 21.39 32 1879 45956 29526660

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 481.13 18.35 335 4130 482370 64011897
Therapy interrupted 477.25 18.35 133 4332 19903 64474364
Therapy cessation 267.61 18.35 96 4369 32393 64461874
Surgery 165.22 18.35 65 4400 28148 64466119
Hospitalisation 147.17 18.35 81 4384 75126 64419141
Intentional dose omission 47.54 18.35 17 4448 5635 64488632
COVID-19 37.28 18.35 33 4432 65107 64429160
Spinal operation 31.92 18.35 13 4452 6120 64488147
Macular degeneration 29.37 18.35 12 4453 5698 64488569
Pneumonia 24.91 18.35 90 4375 559486 63934781
Knee operation 21.48 18.35 9 4456 4548 64489719
Cardiac pacemaker insertion 20.64 18.35 9 4456 5014 64489253
Chronic sinusitis 18.70 18.35 9 4456 6283 64487984

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05227 KEGG_DRUG
C0257715 UMLSCUI
CHEBI:135526 CHEBI
CHEMBL1201147 ChEMBL_ID
DB09535 DRUGBANK_ID
C088673 MESH_SUPPLEMENTAL_RECORD_UI
22571 PUBCHEM_CID
4719 INN_ID
5A68WGF6WM UNII
77674 RXNORM
004367 NDDF
423007005 SNOMEDCT_US
69296007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.02 g TOPICAL OTC monograph final 8 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.02 g TOPICAL OTC monograph final 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.10 g TOPICAL OTC monograph final 8 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 100 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Mederma HUMAN OTC DRUG LABEL 3 0259-3192 CREAM 100 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 10 g TOPICAL OTC monograph final 10 sections
Cetaphil HUMAN OTC DRUG LABEL 2 0299-3928 LOTION 10 g TOPICAL OTC monograph final 10 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35 HUMAN OTC DRUG LABEL 4 0299-4113 LOTION 70 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 80 mg TOPICAL OTC monograph final 12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 HUMAN OTC DRUG LABEL 4 0299-4118 LOTION 80 mg TOPICAL OTC monograph final 12 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 7 g TOPICAL OTC monograph final 8 sections
Cetaphil Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4123 LOTION 7 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4133 LOTION 7 g TOPICAL OTC monograph final 9 sections
Cetaphil PRO Oil Absorbing SPF 30 HUMAN OTC DRUG LABEL 3 0299-4313 LOTION 7 g TOPICAL OTC monograph final 8 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 7 g TOPICAL OTC monograph final 9 sections
Differin Oil Absorbing Moisturizer SPF 30 HUMAN OTC DRUG LABEL 3 0299-4607 LOTION 7 g TOPICAL OTC monograph final 9 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 70 mg TOPICAL OTC monograph final 11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 70 mg TOPICAL OTC monograph final 11 sections
Almay Healthy Biome Makeup HUMAN OTC DRUG LABEL 5 0311-0723 EMULSION 5 mg TOPICAL OTC monograph final 7 sections
Blue Lizard Regular HUMAN OTC DRUG LABEL 4 0316-2010 LOTION 20.40 mg TOPICAL OTC monograph final 8 sections
Blue Lizard Sport Original Sunscreen HUMAN OTC DRUG LABEL 4 0316-2019 LOTION 20.40 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Sport Sunscreen HUMAN OTC DRUG LABEL 2 0316-2021 LOTION 41.80 mg TOPICAL OTC monograph not final 9 sections
Blue Lizard Kids Sunscreen HUMAN OTC DRUG LABEL 2 0316-2061 LOTION 41.80 mg TOPICAL OTC monograph not final 8 sections
Blue Lizard Active Sunscreen HUMAN OTC DRUG LABEL 2 0316-2071 LOTION 41.80 mg TOPICAL OTC monograph not final 9 sections
Hydrating Antioxidant Moiturizer HUMAN OTC DRUG LABEL 4 0363-0540 CREAM 2.36 1 TOPICAL OTC monograph not final 11 sections
Walgreens 7-in-1 Anti-Aging Vitamin Complex Broad Spectrum SPF 15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0692 CREAM 8 mg TOPICAL OTC monograph not final 12 sections
Walgreens Advanced Anti-Wrinkle and Firming Day Cream Broad Spectrum SPF18 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0815 CREAM 5 g TOPICAL OTC monograph not final 11 sections
WALGREEN SPORT SPF 70 SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0900 LOTION 70 mg TOPICAL OTC monograph not final 12 sections
WALGREENS SPORT SPF 50 SUNSCREEN HUMAN OTC DRUG LABEL 4 0363-0924 AEROSOL, SPRAY 50 mg TOPICAL OTC monograph not final 13 sections
WALGREENS BROAD SPECTRUM SPF 110 AGE PROTECTION SUNSCREEN HUMAN OTC DRUG LABEL 5 0363-0933 LOTION 100 mg TOPICAL OTC monograph not final 12 sections