octocrylene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3395 | 6197-30-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
ingredient in sunscreens and cosmetics
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 21, 2006 | FDA | LOREAL USA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 611.18 | 17.90 | 166 | 4537 | 18742 | 56268622 |
| Therapy interrupted | 249.44 | 17.90 | 90 | 4613 | 25535 | 56261829 |
| Death | 141.07 | 17.90 | 157 | 4546 | 341269 | 55946095 |
| Therapy cessation | 138.90 | 17.90 | 60 | 4643 | 27204 | 56260160 |
| Chronic sinusitis | 106.68 | 17.90 | 36 | 4667 | 8342 | 56279022 |
| Paraesthesia oral | 87.57 | 17.90 | 36 | 4667 | 14413 | 56272951 |
| Drug ineffective | 84.20 | 17.90 | 214 | 4489 | 918775 | 55368589 |
| Procedural pain | 76.93 | 17.90 | 34 | 4669 | 16237 | 56271127 |
| Surgery | 73.19 | 17.90 | 41 | 4662 | 32445 | 56254919 |
| Hospitalisation | 70.99 | 17.90 | 55 | 4648 | 74945 | 56212419 |
| Therapeutic product effect incomplete | 40.45 | 17.90 | 47 | 4656 | 105984 | 56181380 |
| Tracheal deviation | 36.93 | 17.90 | 7 | 4696 | 151 | 56287213 |
| Intentional dose omission | 36.24 | 17.90 | 15 | 4688 | 6095 | 56281269 |
| Phrenic nerve paralysis | 35.61 | 17.90 | 7 | 4696 | 184 | 56287180 |
| Dyspepsia | 33.50 | 17.90 | 38 | 4665 | 83433 | 56203931 |
| Body tinea | 30.09 | 17.90 | 9 | 4694 | 1411 | 56285953 |
| Local anaesthetic systemic toxicity | 26.23 | 17.90 | 7 | 4696 | 727 | 56286637 |
| Inhibitory drug interaction | 25.65 | 17.90 | 9 | 4694 | 2335 | 56285029 |
| Pyrexia | 24.82 | 17.90 | 84 | 4619 | 418689 | 55868675 |
| Infection susceptibility increased | 24.15 | 17.90 | 9 | 4694 | 2774 | 56284590 |
| Jarisch-Herxheimer reaction | 21.19 | 17.90 | 5 | 4698 | 315 | 56287049 |
| Dermatophytosis | 18.42 | 17.90 | 4 | 4699 | 173 | 56287191 |
| Glucose tolerance impaired | 18.23 | 17.90 | 9 | 4694 | 5496 | 56281868 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Death | 204.04 | 21.49 | 196 | 2491 | 360373 | 31334284 |
| Therapy interrupted | 148.29 | 21.49 | 49 | 2638 | 10547 | 31684110 |
| Therapy cessation | 95.91 | 21.49 | 39 | 2648 | 15016 | 31679641 |
| Surgery | 61.40 | 21.49 | 27 | 2660 | 12572 | 31682085 |
| Appendicolith | 40.44 | 21.49 | 16 | 2671 | 5715 | 31688942 |
| Hospitalisation | 37.18 | 21.49 | 32 | 2655 | 49775 | 31644882 |
| Appendicitis | 35.57 | 21.49 | 18 | 2669 | 11447 | 31683210 |
| Ventricular fibrillation | 27.24 | 21.49 | 18 | 2669 | 18830 | 31675827 |
| Ascites | 25.92 | 21.49 | 24 | 2663 | 40989 | 31653668 |
| Constipation | 24.13 | 21.49 | 40 | 2647 | 123951 | 31570706 |
| Stress | 22.71 | 21.49 | 18 | 2669 | 24923 | 31669734 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Therapy interrupted | 411.40 | 17.00 | 134 | 6590 | 24668 | 70897052 |
| Death | 379.95 | 17.00 | 341 | 6383 | 509720 | 70412000 |
| Therapy cessation | 234.58 | 17.00 | 96 | 6628 | 33580 | 70888140 |
| Surgery | 144.70 | 17.00 | 66 | 6658 | 29923 | 70891797 |
| Hospitalisation | 121.23 | 17.00 | 83 | 6641 | 82485 | 70839235 |
| Macular degeneration | 98.16 | 17.00 | 34 | 6690 | 7494 | 70914226 |
| Chronic sinusitis | 94.32 | 17.00 | 34 | 6690 | 8417 | 70913303 |
| Paraesthesia oral | 77.70 | 17.00 | 35 | 6689 | 15382 | 70906338 |
| Procedural pain | 66.51 | 17.00 | 33 | 6691 | 17976 | 70903744 |
| Intentional dose omission | 38.96 | 17.00 | 17 | 6707 | 6924 | 70914796 |
| Appendicolith | 38.82 | 17.00 | 16 | 6708 | 5664 | 70916056 |
| Therapeutic product effect incomplete | 37.05 | 17.00 | 51 | 6673 | 119831 | 70801889 |
| Tracheal deviation | 35.50 | 17.00 | 7 | 6717 | 164 | 70921556 |
| Local anaesthetic systemic toxicity | 33.37 | 17.00 | 9 | 6715 | 856 | 70920864 |
| Phrenic nerve paralysis | 31.02 | 17.00 | 7 | 6717 | 318 | 70921402 |
| Body tinea | 29.20 | 17.00 | 9 | 6715 | 1374 | 70920346 |
| Appendicitis | 27.33 | 17.00 | 18 | 6706 | 16715 | 70905005 |
| Spinal operation | 26.30 | 17.00 | 13 | 6711 | 7015 | 70914705 |
| Dyspepsia | 24.70 | 17.00 | 36 | 6688 | 89041 | 70832679 |
| COVID-19 | 22.72 | 17.00 | 38 | 6686 | 105719 | 70816001 |
| Infection susceptibility increased | 22.51 | 17.00 | 9 | 6715 | 2948 | 70918772 |
| Pyrexia | 22.42 | 17.00 | 115 | 6609 | 606837 | 70314883 |
| Ventricular fibrillation | 21.60 | 17.00 | 19 | 6705 | 27092 | 70894628 |
| Inhibitory drug interaction | 20.31 | 17.00 | 9 | 6715 | 3798 | 70917922 |
| Ascites | 19.75 | 17.00 | 28 | 6696 | 67519 | 70854201 |
| Knee operation | 17.89 | 17.00 | 9 | 6715 | 5038 | 70916682 |
| Cardiac pacemaker insertion | 17.36 | 17.00 | 9 | 6715 | 5363 | 70916357 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D05227 | KEGG_DRUG |
| C0257715 | UMLSCUI |
| CHEBI:135526 | CHEBI |
| CHEMBL1201147 | ChEMBL_ID |
| DB09535 | DRUGBANK_ID |
| C088673 | MESH_SUPPLEMENTAL_RECORD_UI |
| 22571 | PUBCHEM_CID |
| 4719 | INN_ID |
| 5A68WGF6WM | UNII |
| 77674 | RXNORM |
| 004367 | NDDF |
| 423007005 | SNOMEDCT_US |
| 69296007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.02 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Thirty SPF 30 | HUMAN OTC DRUG LABEL | 5 | 0096-0685 | CREAM | 0.02 g | TOPICAL | OTC monograph final | 8 sections |
| Daily Facial MoisturizerSPF 25 | HUMAN OTC DRUG LABEL | 4 | 0096-0721 | CREAM | 0.02 g | TOPICAL | OTC monograph final | 11 sections |
| Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.10 g | TOPICAL | OTC monograph final | 8 sections |
| Solbar Fifty SPF50 | HUMAN OTC DRUG LABEL | 4 | 0096-0741 | CREAM | 0.10 g | TOPICAL | OTC monograph final | 8 sections |
| Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 100 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Mederma | HUMAN OTC DRUG LABEL | 3 | 0259-3192 | CREAM | 100 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Cetaphil | HUMAN OTC DRUG LABEL | 2 | 0299-3928 | LOTION | 10 g | TOPICAL | OTC monograph final | 10 sections |
| Cetaphil | HUMAN OTC DRUG LABEL | 2 | 0299-3928 | LOTION | 10 g | TOPICAL | OTC monograph final | 10 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 35 | HUMAN OTC DRUG LABEL | 4 | 0299-4113 | LOTION | 70 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 | HUMAN OTC DRUG LABEL | 4 | 0299-4118 | LOTION | 80 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30 | HUMAN OTC DRUG LABEL | 4 | 0299-4118 | LOTION | 80 mg | TOPICAL | OTC monograph final | 12 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4123 | LOTION | 7 g | TOPICAL | OTC monograph final | 8 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4123 | LOTION | 7 g | TOPICAL | OTC monograph final | 8 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4133 | LOTION | 7 g | TOPICAL | OTC monograph final | 9 sections |
| Cetaphil Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4134 | LOTION | 7 g | TOPICAL | OTC monograph final | 8 sections |
| Cetaphil PRO Oil Absorbing SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4313 | LOTION | 7 g | TOPICAL | OTC monograph final | 8 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4607 | LOTION | 7 g | TOPICAL | OTC monograph final | 9 sections |
| Differin Oil Absorbing Moisturizer SPF 30 | HUMAN OTC DRUG LABEL | 3 | 0299-4607 | LOTION | 7 g | TOPICAL | OTC monograph final | 9 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 70 mg | TOPICAL | OTC monograph final | 11 sections |
| Cetaphil Daily Facial Moisturizer with suncreen SPF 50 | HUMAN OTC DRUG LABEL | 5 | 0299-4930 | LOTION | 70 mg | TOPICAL | OTC monograph final | 11 sections |
| Almay Healthy Biome Makeup | HUMAN OTC DRUG LABEL | 5 | 0311-0723 | EMULSION | 5 mg | TOPICAL | OTC monograph final | 7 sections |
| Blue Lizard Regular | HUMAN OTC DRUG LABEL | 4 | 0316-2010 | LOTION | 20.40 mg | TOPICAL | OTC monograph final | 8 sections |
| Blue Lizard Sport Original Sunscreen | HUMAN OTC DRUG LABEL | 4 | 0316-2019 | LOTION | 20.40 mg | TOPICAL | OTC monograph not final | 8 sections |
| Blue Lizard Sport Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0316-2021 | LOTION | 41.80 mg | TOPICAL | OTC monograph not final | 9 sections |
| Blue Lizard Kids Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0316-2061 | LOTION | 41.80 mg | TOPICAL | OTC monograph not final | 8 sections |
| Blue Lizard Active Sunscreen | HUMAN OTC DRUG LABEL | 2 | 0316-2071 | LOTION | 41.80 mg | TOPICAL | OTC monograph not final | 9 sections |
| Walgreens SPF 70 Sport Continuous | HUMAN OTC DRUG LABEL | 4 | 0363-0035 | SPRAY | 100 mg | TOPICAL | OTC monograph not final | 12 sections |
| Hydrating Antioxidant Moiturizer | HUMAN OTC DRUG LABEL | 4 | 0363-0540 | CREAM | 2.36 1 | TOPICAL | OTC monograph not final | 11 sections |
| Walgreens 7-in-1 Anti-Aging Vitamin Complex Broad Spectrum SPF 15 Sunscreen | HUMAN OTC DRUG LABEL | 3 | 0363-0692 | CREAM | 8 mg | TOPICAL | OTC monograph not final | 12 sections |