mizoribine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
ribofuranyl-derivatives of the "pyrazofurin" type 3363 50924-49-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mizoribine
  • bredinin
  • beta-Bredinin
imidazole nucleoside with immunosuppressive activity isolated from culture filtrate of Eupenicillium brefeldianum; structure
  • Molecular weight: 259.22
  • Formula: C9H13N3O6
  • CLOGP: -1.36
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 151.06
  • ALOGS: -0.86
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis 38.78 30.69 15 954 22502 50581653
Pharyngitis 38.68 30.69 14 955 17489 50586666
Hyperuricaemia 37.29 30.69 10 959 4670 50599485
Hyperlipidaemia 34.98 30.69 13 956 17477 50586678
Iron deficiency anaemia 31.80 30.69 12 957 16822 50587333

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 41.51 29.41 20 1670 37179 64459863
Pharyngitis 40.06 29.41 16 1674 19023 64478019
N-telopeptide urine increased 36.55 29.41 5 1685 42 64497000
Kidney transplant rejection 34.78 29.41 12 1678 9499 64487543
Osteonecrosis 34.00 29.41 16 1674 28213 64468829
Hyperuricaemia 33.97 29.41 12 1678 10179 64486863
Hyperlipidaemia 33.90 29.41 15 1675 22961 64474081
Iron deficiency anaemia 31.36 29.41 14 1676 21875 64475167
Diabetes mellitus 30.66 29.41 20 1670 66454 64430588

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000962 Antimalarials
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:149553 anticoronaviral drug

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.79 acidic
pKa2 11.55 acidic
pKa3 11.83 acidic
pKa4 12.51 acidic
pKa5 13.19 acidic
pKa6 3.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01392 KEGG_DRUG
C0128608 UMLSCUI
CHEBI:31858 CHEBI
MZR PDB_CHEM_ID
CHEMBL245019 ChEMBL_ID
DB12617 DRUGBANK_ID
C010052 MESH_SUPPLEMENTAL_RECORD_UI
104762 PUBCHEM_CID
5120 INN_ID
4JR41A10VP UNII
772627008 SNOMEDCT_US

Pharmaceutical products:

None