mesterolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| androgens/anabolic steroids | 3342 | 1424-00-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one. A synthetic steroid with anabolic and androgenic activities.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 3 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03BB01 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ANDROGENS 5-androstanon (3) derivatives |
| MeSH PA | D045930 | Anabolic Agents |
| MeSH PA | D006728 | Hormones |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sex hormone-binding globulin | Secreted | Kd | 9.60 | CHEMBL | |||||
| Androgen receptor | Transcription factor | IC50 | 4.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167465 | NUI |
| D04947 | KEGG_DRUG |
| C0025503 | UMLSCUI |
| CHEBI:135293 | CHEBI |
| CHEMBL258918 | ChEMBL_ID |
| DB13587 | DRUGBANK_ID |
| D008655 | MESH_DESCRIPTOR_UI |
| 15020 | PUBCHEM_CID |
| 1965 | INN_ID |
| 0SRQ75X9I9 | UNII |
| 6781 | RXNORM |
| 004004 | NDDF |
| 126166005 | SNOMEDCT_US |
| 96346001 | SNOMEDCT_US |
Pharmaceutical products:
None