benzatropine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
atropine derivatives	333	86-13-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cogentin benztropine mesilate benzatropine benztropine tropine benzohydryl ether benztropine mesylate	A centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. Molecular weight: 307.44 Formula: C21H25NO CLOGP: 3.52 LIPINSKI: 0 HAC: 2 HDO: 0 TPSA: 12.47 ALOGS: -5.41 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
2	mg	O
2	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Hosey CM, Chan R, Benet LZ
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.21 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	29 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 5, 1954	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	510.21	58.62	111	282	20923	2336769
Toxicity to various agents	297.77	58.62	79	314	32675	2325017
Ileus paralytic	106.49	58.62	18	375	778	2356914
Cardiac arrest	74.73	58.62	23	370	14907	2342785
Cardio-respiratory arrest	71.83	58.62	20	373	9126	2348566
Neuroleptic malignant syndrome	65.82	58.62	14	379	2066	2355626

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	451.65	63.82	112	411	16200	1730058
Toxicity to various agents	298.17	63.82	92	431	29049	1717209
Drug abuse	230.41	63.82	64	459	13625	1732633
Agitation	82.95	63.82	28	495	10998	1735260
Neuroleptic malignant syndrome	72.36	63.82	19	504	3129	1743129
Intentional product misuse	68.58	63.82	22	501	7336	1738922

Pharmacologic Action:

Source	Code	Description
ATC	N04AC01	NERVOUS SYSTEM ANTI-PARKINSON DRUGS ANTICHOLINERGIC AGENTS Ethers of tropine or tropine derivatives
CHEBI has role	CHEBI:66956	antidyskinesia agent
CHEBI has role	CHEBI:48876	muscarinic antagonist
CHEBI has role	CHEBI:146270	oneirogen
CHEBI has role	CHEBI:48407	antiparkinson drug
CHEBI has role	CHEBI:50370	parasympatholytic
MeSH PA	D018726	Anti-Dyskinesia Agents
MeSH PA	D000978	Antiparkinson Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018678	Cholinergic Agents
MeSH PA	D018680	Cholinergic Antagonists
MeSH PA	D015259	Dopamine Agents
MeSH PA	D018765	Dopamine Uptake Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018727	Muscarinic Antagonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D010276	Parasympatholytics
MeSH PA	D018373	Peripheral Nervous System Agents
FDA EPC	N0000175574	Anticholinergic
FDA EPC	N0000175750	Antihistamine
FDA MoA	N0000000207	Histamine Receptor Antagonists

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Postencephalitic parkinsonism	indication	19972008	DOID:14332
Parkinsonism	indication	32798002
Parkinson's disease	indication	49049000	DOID:14330
Extrapyramidal disease	indication	76349003
Arteriosclerotic Parkinsonism	indication
Urinary tract obstruction	contraindication	7163005	DOID:5200
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Severe chronic ulcerative colitis	contraindication	14311001
Disorder of autonomic nervous system	contraindication	15241006
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Shigellosis	contraindication	36188001
Hypertensive disorder	contraindication	38341003	DOID:10763
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Dysuria	contraindication	49650001
Paralytic ileus	contraindication	55525008	DOID:8442
Ulcerative colitis	contraindication	64766004	DOID:8577
Hiatal hernia	contraindication	84089009	DOID:12642
Open-angle glaucoma	contraindication	84494001	DOID:1067
Kidney disease	contraindication	90708001	DOID:557
Thyrotoxicosis	contraindication	90739004	DOID:7997
Myasthenia gravis	contraindication	91637004	DOID:437
Tardive dyskinesia	contraindication	102449007
Dysentery	contraindication	111939009
Gastrointestinal obstruction	contraindication	126765001
Bleeding	contraindication	131148009
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Fever	contraindication	386661006
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Pseudomembranous enterocolitis	contraindication	397683000
Gastric ulcer	contraindication	397825006	DOID:10808
Disorder of coronary artery	contraindication	414024009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.86	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN	ANTAGONIST	Ki	9.64		WOMBAT-PK	CHEMBL
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN	ANTAGONIST	Ki	8.55		WOMBAT-PK
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN	ANTAGONIST	Ki	8.96		WOMBAT-PK
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN	ANTAGONIST	Ki	8.96		WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN	ANTAGONIST	Ki	8.85		WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.69		DRUG MATRIX
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7.23		DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.86		DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	8.16		DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.90		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	7.49		DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.89		DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7.52		DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.65		DRUG MATRIX
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	5.93		DRUG MATRIX
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.24		DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	7.59		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		IC50	4.62		CHEMBL
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	8.96		WOMBAT-PK
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Kd	7.25		WOMBAT-PK
Sodium-dependent neutral amino acid transporter B(0)AT1	Unclassified	Q695T7	S6A19_HUMAN	INHIBITOR	IC50	4.36		IUPHAR
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	7.39		DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		Ki	6.95		DRUG MATRIX
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	5.29		CHEMBL
Sodium-dependent dopamine transporter	Transporter		SC6A3_RAT		Ki	6.93		CHEMBL
Muscarinic acetylcholine receptor M1	GPCR		ACM1_RAT		Ki	9.23		CHEMBL
Muscarinic acetylcholine receptor M2	GPCR		ACM2_RAT		Ki	8.59		CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	6.85		CHEMBL

External reference:

ID	Source
D001590	MESH_DESCRIPTOR_UI
C0591275	UMLSCUI
D00778	KEGG_DRUG
1NHL2J4X8K	UNII
292	INN_ID
372846002	SNOMEDCT_US
77390008	SNOMEDCT_US
4019630	VANDF
004667	NDDF
1424	RXNORM
d00175	MMSL
DB00245	DRUGBANK_ID
CHEMBL1200383	ChEMBL_ID
CXQ	PDB_CHEM_ID
CHEBI:3048	CHEBI
132-17-2	SECONDARY_CAS_RN
7601	IUPHAR_LIGAND_ID
1201549	PUBCHEM_CID
CHEMBL1201203	ChEMBL_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9729	INJECTION	1 mg	INTRAMUSCULAR	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2437	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2438	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0603-2439	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-2547	TABLET	0.50 mg	ORAL	ANDA	11 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-2548	TABLET	1 mg	ORAL	ANDA	11 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-2549	TABLET	2 mg	ORAL	ANDA	11 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7675	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7676	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7677	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8210	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8211	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1080	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1081	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1082	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6788	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6789	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6790	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	10135-606	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	10135-607	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	10135-608	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	17478-012	INJECTION	1 mg	INTRAVENOUS	NDA authorized generic	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	31722-218	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	31722-219	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	31722-220	TABLET	2 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	43353-580	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	43353-707	TABLET	0.50 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	43353-796	TABLET	1 mg	ORAL	ANDA	12 sections
Benztropine Mesylate	HUMAN PRESCRIPTION DRUG LABEL	1	43353-913	TABLET	0.50 mg	ORAL	ANDA	12 sections
BENZTROPINE MESYLATE	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3882	TABLET	2 mg	ORAL	ANDA	13 sections