meclocycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, protein-synthesis inhibitors, tetracycline derivatives 3333 2013-58-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • meclan
  • meclocycline
  • meclocycline sulfosalicylate
  • Molecular weight: 476.87
  • Formula: C22H21ClN2O8
  • CLOGP: -0.44
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 6
  • TPSA: 181.62
  • ALOGS: -2.94
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA JOHNSON AND JOHNSON

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D10AF04 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Antiinfectives for treatment of acne
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Trachoma indication 2576002 DOID:11265
Actinomycotic infection indication 11817007 DOID:8478
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Gingivostomatitis indication 20607006
Acute gonococcal cervicitis indication 20943002 DOID:10615
Granuloma inguinale indication 28867007 DOID:9113
Acute gonococcal urethritis indication 29864006
Bronchitis indication 32398004 DOID:6132
Sinusitis indication 36971009
Gonorrhea of rectum indication 42746002
Klebsiella cystitis indication 60867007
Acute gonococcal endometritis indication 65295003 DOID:7527
Urinary tract infectious disease indication 68566005
Yaws indication 70647001 DOID:10371
Gonorrhea of pharynx indication 74372003
Rickettsialpox indication 75096007 DOID:11103
Ornithosis indication 75116005 DOID:11262
Acute bacterial sinusitis indication 75498004
Brucellosis indication 75702008 DOID:11077
Syphilis indication 76272004
Acne vulgaris indication 88616000
Rocky Mountain spotted fever indication 186772009
Q fever indication 186788009 DOID:11100
Lymphogranuloma venereum indication 186946009 DOID:13819
Pneumonia indication 233604007 DOID:552
Inclusion conjunctivitis indication 266109000
Chancroid indication 266143009 DOID:13778
Infective otitis media indication 312218008
Pharyngitis indication 405737000 DOID:2275
Infection due to Staphylococcus aureus indication 406602003
Anthrax indication 409498004 DOID:7427
Relapsing fever indication 420079008 DOID:13034
Haemophilus Influenzae Pharyngitis indication
Haemophilus Influenzae Acute Otitis Media indication
Typhus Infections indication
Tularemia off-label use 19265001
Enterocolitis off-label use 43752006
Pneumonia due to Mycoplasma pneumoniae off-label use 46970008
Syndrome of inappropriate vasopressin secretion off-label use 55004003 DOID:3401
Plague off-label use 58750007 DOID:3482
Cholangitis off-label use 82403002 DOID:9446
Chlamydial infection off-label use 105629000
Infectious disease of abdomen off-label use 128070006
Ocular rosacea off-label use 200933006
Minor Bacterial Skin Infections off-label use
Diabetes insipidus contraindication 15771004 DOID:9409
Kidney disease contraindication 90708001 DOID:557
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.39 acidic
pKa2 6.97 acidic
pKa3 9.46 acidic
pKa4 10.69 acidic
pKa5 11.35 acidic
pKa6 13.08 acidic
pKa7 8.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02476 KEGG_DRUG
73816-42-9 SECONDARY_CAS_RN
C0065841 UMLSCUI
CHEBI:135772 CHEBI
CHEMBL1237124 ChEMBL_ID
CHEMBL261772 ChEMBL_ID
DB13092 DRUGBANK_ID
C100122 MESH_SUPPLEMENTAL_RECORD_UI
1566 INN_ID
23Q8M2HE6S UNII
54676539 PUBCHEM_CID
203162 RXNORM
1690 MMSL
5030 MMSL
002752 NDDF
002753 NDDF
27079005 SNOMEDCT_US
371167002 SNOMEDCT_US
6162007 SNOMEDCT_US

Pharmaceutical products:

None