lubeluzole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3328 | 144665-07-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a benzothiazole compound; used for the treatment of acute ischemic stroke; R-91154 is the inactive isomer
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 2.60 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 21.60 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018696 | Neuroprotective Agents |
| MeSH PA | D020011 | Protective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.78 | Basic |
| pKa2 | 3.45 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein type 2 subunit alpha | Ion channel | IC50 | 6.59 | CHEMBL | |||||
| Calmodulin | Cytosolic other | Kd | 5.54 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D04789 | KEGG_DRUG |
| C0385965 | UMLSCUI |
| CHEMBL281724 | ChEMBL_ID |
| C097722 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7198 | INN_ID |
| V2SIB71583 | UNII |
| 65998 | PUBCHEM_CID |
Pharmaceutical products:
None