All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

linoleic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3323	60-33-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: linoleic acid alpha-Linoleic acid linolic acid	A doubly unsaturated fatty acid, occurring widely in plant glycosides. It is an essential fatty acid in mammalian nutrition and is used in the biosynthesis of prostaglandins and cell membranes. (From Stedman, 26th ed) Molecular weight: 280.45 Formula: C18H32O2 CLOGP: 7.30 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -6.26 ROTB: 14

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatotoxicity	64.97	46.73	16	167	37025	63451814

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hepatotoxicity	57.62	50.99	16	244	51336	79692792
Regurgitation	53.25	50.99	9	251	2778	79741350

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:83038	Daphnia galeata metabolites
CHEBI has role	CHEBI:84735	algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.76	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	4.89		CHEMBL
Aromatase	Enzyme	P11511	CP19A_HUMAN		IC50	4.32		CHEMBL
Aldo-keto reductase family 1 member C3	Enzyme	P42330	AK1C3_HUMAN		IC50	6.16		CHEMBL
Peroxisome proliferator-activated receptor alpha	Nuclear hormone receptor	Q07869	PPARA_HUMAN		Kd	8.32		CHEMBL
Peroxisome proliferator-activated receptor gamma	Nuclear hormone receptor	P37231	PPARG_HUMAN		IC50	5.21		CHEMBL
Fatty acid-binding protein, adipocyte	Cytosolic other	P15090	FABP4_HUMAN		IC50	6		CHEMBL
Fatty acid-binding protein, heart	Cytosolic other	P05413	FABPH_HUMAN		Kd	9.70		CHEMBL
Peroxisome proliferator-activated receptor delta	Nuclear hormone receptor	Q03181	PPARD_HUMAN		IC50	5		CHEMBL
Free fatty acid receptor 1	GPCR	O14842	FFAR1_HUMAN	AGONIST	EC50	5.70		IUPHAR
Potassium voltage-gated channel subfamily B member 1	Ion channel	Q14721	KCNB1_HUMAN	ACTIVATOR	EC50	5.60		IUPHAR
Tissue factor	Membrane receptor	P13726	TF_HUMAN		IC50	4.39		CHEMBL
Free fatty acid receptor 4	GPCR	Q5NUL3	FFAR4_HUMAN	AGONIST	EC50	5.89		IUPHAR
Nuclear receptor subfamily 4 group A member 2	Nuclear other	P43354	NR4A2_HUMAN		Kd	4.30		CHEMBL
Adenosine receptor A1	GPCR		AA1R_RAT		IC50	4.19		CHEMBL
Seed linoleate 13S-lipoxygenase-1	Enzyme		LOX1_SOYBN		IC50	6		CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP		IC50	4.03		CHEMBL

External reference:

ID	Source
4020238	VUID
N0000148142	NUI
4020238	VANDF
C0023749	UMLSCUI
CHEBI:17351	CHEBI
EIC	PDB_CHEM_ID
CHEMBL267476	ChEMBL_ID
DB14104	DRUGBANK_ID
D019787	MESH_DESCRIPTOR_UI
5280450	PUBCHEM_CID
1052	IUPHAR_LIGAND_ID
9KJL21T0QJ	UNII
6400	RXNORM
005003	NDDF
012326	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
PrimaCare	HUMAN PRESCRIPTION DRUG LABEL	14	75854-322	PILL	50 mg	oral	unapproved drug other	11 sections
Dr.Different VITAACNAL TX Capsule Serum	HUMAN OTC DRUG LABEL	2	81710-110	LIQUID	0.76 g	TOPICAL	unapproved drug other	8 sections
Anubis Barcelona Vital Line	HUMAN OTC DRUG LABEL	23	83021-064	CREAM	0.16 g	TOPICAL	OTC monograph final	5 sections
AnubisMed	HUMAN OTC DRUG LABEL	28	83021-551	CREAM	0.50 g	TOPICAL	OTC monograph final	7 sections
Anubis Barcelona Protective Line	HUMAN OTC DRUG LABEL	27	83021-686	CREAM	0.50 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Protective Line	HUMAN OTC DRUG LABEL	27	83021-686	CREAM	0.50 g	TOPICAL	OTC monograph final	9 sections