isoconazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 3309 27523-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoconazole
  • isoconazole nitrate
  • Molecular weight: 416.12
  • Formula: C18H14Cl4N2O
  • CLOGP: 5.81
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 27.05
  • ALOGS: -5.70
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.60 g V

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC05 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC G01AF07 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Steroid 17-alpha-hydroxylase/17,20 lyase Enzyme Ki 6.21 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.64 CHEMBL

External reference:

IDSource
D01480 KEGG_DRUG
C0063953 UMLSCUI
CHEBI:82865 CHEBI
CHEMBL1571863 ChEMBL_ID
DB08943 DRUGBANK_ID
C020382 MESH_SUPPLEMENTAL_RECORD_UI
3760 PUBCHEM_CID
3505 INN_ID
24168-96-5 SECONDARY_CAS_RN
GRI7WFR424 UNII
203157 RXNORM
003740 NDDF
003986 NDDF
350201001 SNOMEDCT_US
418371001 SNOMEDCT_US
712726005 SNOMEDCT_US

Pharmaceutical products:

None