oxyquinoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3290 | 148-24-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 80 | mg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Allergy to plants | 62.80 | 49.96 | 10 | 574 | 746 | 63487692 |
| Elbow deformity | 55.86 | 49.96 | 10 | 574 | 1505 | 63486933 |
| Transplant dysfunction | 55.25 | 49.96 | 12 | 572 | 4860 | 63483578 |
| Wrist deformity | 52.46 | 49.96 | 10 | 574 | 2120 | 63486318 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Apparent death | 148.97 | 102.76 | 28 | 1391 | 2837 | 79740132 |
| Intestinal sepsis | 137.17 | 102.76 | 22 | 1397 | 877 | 79742092 |
| Pulmonary thrombosis | 113.53 | 102.76 | 29 | 1390 | 12142 | 79730827 |
| Terminal state | 111.17 | 102.76 | 24 | 1395 | 4865 | 79738104 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A01AB07 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
| ATC | D08AH03 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Quinoline derivatives |
| ATC | G01AC30 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Quinoline derivatives |
| ATC | R02AA14 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics |
| CHEBI has role | CHEBI:33282 | bactericides |
| CHEBI has role | CHEBI:38157 | iron chelating agents |
| CHEBI has role | CHEBI:48218 | antiseptics |
| CHEBI has role | CHEBI:86328 | anti-fungal agrichemical |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Sensation Disturbance of Genitals | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.78 | acidic |
| pKa2 | 4.73 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 72 kDa type IV collagenase | Enzyme | IC50 | 3.89 | CHEMBL | |||||
| Catechol O-methyltransferase | Enzyme | IC50 | 5.80 | CHEMBL | |||||
| Histone deacetylase 8 | Enzyme | EC50 | 4.96 | CHEMBL | |||||
| Methionine aminopeptidase 2 | Enzyme | IC50 | 5.69 | CHEMBL | |||||
| Methionine aminopeptidase 1 | Enzyme | IC50 | 4.67 | CHEMBL | |||||
| Catechol O-methyltransferase | Enzyme | IC50 | 4.67 | CHEMBL | |||||
| Bacterial leucyl aminopeptidase | Enzyme | Ki | 6.80 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018497 | VUID |
| N0000146819 | NUI |
| D02414 | KEGG_DRUG |
| 134-31-6 | SECONDARY_CAS_RN |
| 4018497 | VANDF |
| 4018927 | VANDF |
| 4020834 | VANDF |
| 4020847 | VANDF |
| C0000665 | UMLSCUI |
| CHEBI:48981 | CHEBI |
| HQI | PDB_CHEM_ID |
| CHEMBL310555 | ChEMBL_ID |
| CHEMBL1697698 | ChEMBL_ID |
| D015125 | MESH_DESCRIPTOR_UI |
| DB11145 | DRUGBANK_ID |
| 5UTX5635HP | UNII |
| 1923 | PUBCHEM_CID |
| 110 | RXNORM |
| 20652 | MMSL |
| NOCODE | MMSL |
| 003184 | NDDF |
| 003908 | NDDF |
| 34217006 | SNOMEDCT_US |
| 412098000 | SNOMEDCT_US |
| 77245001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Trimo-San | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0295-5030 | JELLY | 0.25 mg | VAGINAL | unapproved drug other | 5 sections |
| Fem pH | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0813-0799 | JELLY | 0 g | VAGINAL | unapproved drug other | 18 sections |
| Fem pH | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0813-0799 | JELLY | 0 g | VAGINAL | unapproved drug other | 18 sections |
| RELEGARD | HUMAN PRESCRIPTION DRUG LABEL | 2 | 51674-0130 | GEL | 0.03 mg | TOPICAL | unapproved drug other | 3 sections |
| TRIMO SAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 59365-5030 | JELLY | 0.25 mg | VAGINAL | unapproved drug other | 9 sections |
| TRIMO SAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 59365-5030 | JELLY | 0.25 mg | VAGINAL | unapproved drug other | 9 sections |