hydroquinone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3282	123-31-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: 1,4-Benzenediol hydroquinone benzene-1,4-diol idrochinone	skin depigmentation agent Molecular weight: 110.11 Formula: C6H6O2 CLOGP: 0.81 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: -0.06 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 18, 2002	FDA	GALDERMA LABS LP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Squamous cell carcinoma of skin	280.10	154.73	34	57	737	2357257
Skin atrophy	164.74	154.73	21	70	624	2357370

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event

Pharmacologic Action:

Source	Code	Description
ATC	D11AX11	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
CHEBI has role	CHEBI:85046	skin lightening agent
MeSH PA	D000975	Antioxidants
MeSH PA	D009153	Mutagens
MeSH PA	D009676	Noxae
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
FDA PE	N0000175851	Depigmenting Activity
FDA EPC	N0000175854	Melanin Synthesis Inhibitor
FDA MoA	N0000175850	Melanin Synthesis Inhibitors

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Discoloration of skin	indication	3253007
Chloasma	indication	36209000
Facial Hyperpigmentation	indication
Sunburn	contraindication	23346002
Eczema	contraindication	43116000
Telangiectasia disorder	contraindication	247479008
Pregnancy, function	contraindication	289908002
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006
Breastfeeding (mother)	contraindication	413712001
Denuded skin	contraindication	418242004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.26	acidic
pKa2	11.59	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	5.09		CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	4.38		CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	4.97		CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	4.97		CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	4.85		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	4.49		CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	5.11		CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	4.90		CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	7.05		CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		Ki	4.13		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	4.97		CHEMBL
Carbonic anhydrase	Unclassified		Q2PCB5_DICLA		Ki	5.23		CHEMBL
Polyphenol oxidase 2	Enzyme		PPO2_AGABI		IC50	5.01		CHEMBL

External reference:

ID	Source
4018886	VUID
N0000147180	NUI
C0020306	UMLSCUI
D00073	KEGG_DRUG
74583006	SNOMEDCT_US
387422001	SNOMEDCT_US
4849	MMSL
5509	RXNORM
1507	MMSL
4018886	VANDF
002019	NDDF
785	PUBCHEM_CID
CHEBI:17594	CHEBI
CHEMBL537	ChEMBL_ID
HQE	PDB_CHEM_ID
DB09526	DRUGBANK_ID
XV74C1N1AE	UNII
C031927	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AMBI Fade	HUMAN OTC DRUG LABEL	2	0187-5479	CREAM	20 mg	TOPICAL	OTC monograph not final	9 sections
AMBI Fade	HUMAN OTC DRUG LABEL	2	0187-5480	CREAM	20 mg	TOPICAL	OTC monograph not final	9 sections
Differin Dark Spot Correcting Serum	HUMAN OTC DRUG LABEL	1	0299-4608	SOLUTION	2 g	TOPICAL	OTC monograph not final	9 sections
TRI-LUMA	HUMAN PRESCRIPTION DRUG LABEL	3	0299-5950	CREAM	40 mg	TOPICAL	NDA	15 sections
Proactiv Advanced Dark Spot Correcting Serum	HUMAN OTC DRUG LABEL	1	11410-045	LIQUID	20 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	9 sections
Artra Skin Tone for Oily Skin	HUMAN OTC DRUG LABEL	3	12022-000	CREAM	75 mg	TOPICAL	OTC monograph not final	6 sections
Artra Skin Tone for Normal Skin	HUMAN OTC DRUG LABEL	3	12022-001	CREAM	20 mg	TOPICAL	OTC monograph not final	6 sections
Artra Skin Tone for Dry Skin	HUMAN OTC DRUG LABEL	3	12022-002	CREAM	20 mg	TOPICAL	OTC monograph not final	6 sections
Black and White Skin Bleach	HUMAN OTC DRUG LABEL	1	12022-003	CREAM	20 mg	TOPICAL	OTC monograph not final	6 sections
Nadinola Skin Fade for Dry Skin	HUMAN OTC DRUG LABEL	2	12022-012	CREAM	20 mg	TOPICAL	OTC monograph not final	6 sections
Nadinola Skin Fade for Oily Skin	HUMAN OTC DRUG LABEL	2	12022-013	CREAM	20 mg	TOPICAL	OTC monograph not final	6 sections
Nadinola Skin FadeExtra	HUMAN OTC DRUG LABEL	2	12022-014	CREAM	30 mg	TOPICAL	OTC monograph not final	6 sections
Nadinola Skin Fade for Normal Skin	HUMAN OTC DRUG LABEL	2	12022-015	CREAM	30 mg	TOPICAL	OTC monograph not final	6 sections
Othine Skin Bleach	HUMAN OTC DRUG LABEL	2	12022-016	CREAM	30 mg	TOPICAL	OTC monograph not final	6 sections
Skin Lightening	HUMAN OTC DRUG LABEL	1	14222-1615	LIQUID	2 mL	TOPICAL	OTC monograph not final	2 sections
Skin Lightening Accelerator Pack	HUMAN OTC DRUG LABEL	2	14222-5000	KIT	2 g	None	OTC monograph not final	8 sections
Skin Lightening Accelerator Pack	HUMAN OTC DRUG LABEL	2	14222-5000	KIT	2 g	None	OTC monograph not final	8 sections
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots	HUMAN OTC DRUG LABEL	6	14222-5030	KIT	2 g	TOPICAL	unapproved drug other	9 sections
REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots	HUMAN OTC DRUG LABEL	6	14222-5030	KIT	2 g	TOPICAL	unapproved drug other	9 sections
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size	HUMAN OTC DRUG LABEL	6	14222-5035	KIT	2 g	TOPICAL	unapproved drug other	10 sections
REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size	HUMAN OTC DRUG LABEL	6	14222-5035	KIT	2 g	TOPICAL	unapproved drug other	10 sections
Skin Beautifying Milk	HUMAN OTC DRUG LABEL	1	16708-001	CREAM	0.02 g	TOPICAL	OTC monograph not final	11 sections
Medicated Fade Creme with Sunscreen	HUMAN OTC DRUG LABEL	2	16708-002	CREAM	0.02 g	TOPICAL	OTC monograph not final	10 sections
Advanced Lightning	HUMAN OTC DRUG LABEL	2	24623-042	CREAM	0.02 g	TOPICAL	OTC MONOGRAPH NOT FINAL	8 sections
Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	24979-141	CREAM	40 mg	TOPICAL	Unapproved drug other	13 sections
hydroquinone time release	HUMAN PRESCRIPTION DRUG LABEL	1	24979-144	CREAM	40 mg	TOPICAL	Unapproved drug other	13 sections
Hydro-Q	HUMAN PRESCRIPTION DRUG LABEL	1	30815-0040	GEL	40 mg	TOPICAL	UNAPPROVED DRUG OTHER	13 sections
HYDROQUINONE 4%	HUMAN PRESCRIPTION DRUG LABEL	1	42192-151	CREAM	40 mg	TOPICAL	unapproved drug other	19 sections
Hydroquinone	HUMAN PRESCRIPTION DRUG LABEL	1	42582-700	CREAM	40 mg	TOPICAL	UNAPPROVED DRUG OTHER	13 sections
MELAMIN Skin Bleaching and Correcting	HUMAN PRESCRIPTION DRUG LABEL	1	42851-030	CREAM	0.04 g	TOPICAL	UNAPPROVED DRUG OTHER	9 sections