hydrogen peroxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3281	7722-84-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: oxydol hydrogen peroxide topical solution hydrogen peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials. Molecular weight: 34.01 Formula: H2O2 CLOGP: LIPINSKI: None HAC: 2 HDO: 2 TPSA: 40.46 ALOGS: ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

oxydol
hydrogen peroxide topical solution
hydrogen peroxide

A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

Molecular weight: 34.01
Formula: H2O2
CLOGP:
LIPINSKI: None
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS:
ROTB: 0

Drug dosage:

Dose	Unit	Route
60	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	10914.97	21.89	3504	23589	142169	63319760
Toxicity to various agents	6201.57	21.89	2674	24419	244576	63217353
Drug abuse	3681.10	21.89	1316	25777	71202	63390727
Cardio-respiratory arrest	2236.89	21.89	870	26223	59089	63402840
Intentional overdose	1551.40	21.89	714	26379	73438	63388491
Respiratory arrest	1384.59	21.89	521	26572	32124	63429805
Overdose	1208.91	21.89	697	26396	114381	63347548
Cardiac arrest	1141.34	21.89	623	26470	91922	63370007
Poisoning	968.48	21.89	320	26773	13380	63448549
Death	926.01	21.89	956	26137	373425	63088504
Suicide attempt	859.56	21.89	449	26644	60469	63401460
Intentional product misuse	833.87	21.89	440	26653	60477	63401452
Alcohol interaction	519.96	21.89	134	26959	2275	63459654
Suspected suicide	414.61	21.89	141	26952	6427	63455502
Alcohol poisoning	391.13	21.89	102	26991	1817	63460112
Exposure via ingestion	349.12	21.89	102	26991	2807	63459122
Alcohol use	345.37	21.89	94	26999	1985	63459944
Exposure to toxic agent	257.62	21.89	95	26998	5492	63456437
Coma	255.52	21.89	215	26878	64149	63397780
Drug ineffective	252.63	21.89	68	27025	1044697	62417232
Alcohol abuse	196.11	21.89	61	27032	2085	63459844
Somnolence	190.87	21.89	302	26791	178383	63283546
Poisoning deliberate	176.04	21.89	89	27004	11129	63450800
Pain	175.18	21.89	50	27043	740578	62721351
Diarrhoea	169.70	21.89	48	27045	715318	62746611
Fatigue	162.58	21.89	89	27004	887939	62573990
Blood alcohol increased	154.08	21.89	39	27054	613	63461316
Dyspnoea	148.43	21.89	49	27044	661264	62800665
Arthralgia	147.05	21.89	32	27061	569678	62892251
Rash	132.16	21.89	38	27055	560833	62901096
Mydriasis	126.43	21.89	73	27020	11883	63450046
Agitation	119.07	21.89	137	26956	59620	63402309
Intentional self-injury	116.94	21.89	93	27000	25594	63436335
Headache	116.29	21.89	63	27030	633178	62828751
Off label use	114.16	21.89	74	27019	674388	62787541
Alcoholism	110.68	21.89	38	27055	1780	63460149
Joint swelling	106.46	21.89	9	27084	327657	63134272
Loss of consciousness	106.29	21.89	185	26908	117936	63343993
Substance abuse	105.42	21.89	48	27045	4759	63457170
Alopecia	102.54	21.89	12	27081	337524	63124405
Drug intolerance	96.21	21.89	10	27083	308651	63153278
Seizure	94.60	21.89	188	26905	132446	63329483
Infusion related reaction	91.31	21.89	3	27090	245518	63216411
Pain in extremity	90.88	21.89	16	27077	331470	63130459
Pyrexia	88.92	21.89	45	27048	470433	62991496
Condition aggravated	87.95	21.89	31	27062	402186	63059743
Pruritus	87.79	21.89	23	27070	361430	63100499
Hypersensitivity	87.41	21.89	11	27082	292674	63169255
Hepatic failure	87.08	21.89	91	27002	35565	63426364
Abdominal discomfort	86.85	21.89	16	27077	320869	63141060
Rheumatoid arthritis	82.33	21.89	7	27086	253812	63208117
Swelling	80.67	21.89	11	27082	275367	63186562
Asthenia	78.16	21.89	33	27060	383571	63078358
Postmortem blood drug level abnormal	77.65	21.89	20	27073	338	63461591
Arthropathy	77.47	21.89	6	27087	234786	63227143
Peripheral swelling	77.01	21.89	11	27082	265931	63195998
Depressed level of consciousness	74.66	21.89	111	26982	61967	63399962
Pneumonia	74.59	21.89	52	27041	456715	63005214
Myocarditis	73.48	21.89	49	27044	10276	63451653
Unresponsive to stimuli	71.53	21.89	80	27013	33736	63428193
Drug hypersensitivity	71.29	21.89	22	27071	310665	63151264
Nausea	70.34	21.89	164	26929	854307	62607622
Urinary tract infection	69.90	21.89	14	27079	264670	63197259
Drug dependence	69.88	21.89	68	27025	24415	63437514
Victim of sexual abuse	69.09	21.89	21	27072	663	63461266
Nasopharyngitis	68.09	21.89	13	27080	254244	63207685
Systemic lupus erythematosus	67.09	21.89	6	27087	208912	63253017
Anaemia	65.16	21.89	22	27071	293408	63168521
Infection	65.14	21.89	10	27083	229163	63232766
Accidental death	64.00	21.89	26	27067	1950	63459979
Drug use disorder	62.38	21.89	34	27059	4950	63456979
Chemical submission	62.37	21.89	16	27077	266	63461663
Metabolic acidosis	62.12	21.89	86	27007	44983	63416946
Back pain	60.05	21.89	19	27074	264126	63197803
Sinusitis	59.81	21.89	12	27081	226641	63235288
Aggression	59.21	21.89	61	27032	23437	63438492
Tachycardia	58.75	21.89	145	26948	118011	63343918
Cough	56.74	21.89	27	27066	292716	63169213
Product dose omission issue	56.67	21.89	15	27078	234298	63227631
Malaise	56.02	21.89	57	27036	415897	63046032
Treatment failure	55.84	21.89	9	27084	199034	63262895
Weight increased	55.42	21.89	21	27072	260771	63201158
Drug withdrawal syndrome	55.23	21.89	63	27030	27131	63434798
Suicidal ideation	55.09	21.89	97	26996	62324	63399605
Electrocardiogram QT prolonged	54.48	21.89	94	26999	59436	63402493
Drug interaction	54.03	21.89	217	26876	228914	63233015
Neutropenia	53.64	21.89	6	27087	174999	63286930
Therapeutic product effect decreased	53.61	21.89	9	27084	193178	63268751
Blood ethanol increased	52.95	21.89	12	27081	114	63461815
Congestive hepatopathy	51.05	21.89	25	27068	2917	63459012
Dizziness	50.24	21.89	66	27027	429859	63032070
Electrocardiogram QRS complex prolonged	49.18	21.89	31	27062	5907	63456022
Decreased appetite	48.88	21.89	23	27070	251029	63210900
Musculoskeletal stiffness	48.23	21.89	10	27083	184608	63277321
Constipation	44.73	21.89	20	27073	224923	63237006
Stomatitis	44.48	21.89	4	27089	138721	63323208
Wound	44.43	21.89	8	27085	163255	63298674
Discomfort	43.85	21.89	9	27084	167365	63294564
Somnambulism	43.57	21.89	28	27065	5515	63456414
Sinus tachycardia	42.30	21.89	52	27041	24216	63437713
Weight decreased	41.91	21.89	34	27059	276764	63185165
Electrocardiogram ST segment elevation	41.57	21.89	24	27069	3903	63458026
Hepatic encephalopathy	41.26	21.89	36	27057	11246	63450683
Sopor	41.09	21.89	49	27044	22115	63439814
Asphyxia	40.79	21.89	28	27065	6153	63455776
Brain oedema	39.71	21.89	39	27054	14156	63447773
Product administration interrupted	39.43	21.89	25	27068	4811	63457118
Lower respiratory tract infection	39.39	21.89	5	27088	132302	63329627
Hypotension	39.31	21.89	224	26869	272380	63189549
Pericarditis	39.11	21.89	5	27088	131574	63330355
Therapeutic product effect incomplete	39.05	21.89	4	27089	125052	63336877
Arthritis	38.10	21.89	3	27090	115918	63346011
Drug screen positive	37.94	21.89	22	27071	3607	63458322
Fall	37.44	21.89	69	27024	392265	63069664
Substance use disorder	37.38	21.89	10	27083	197	63461732
Chest pain	37.32	21.89	23	27070	215936	63245993
Contraindicated product administered	36.49	21.89	24	27069	217624	63244305
Victim of chemical submission	35.84	21.89	12	27081	520	63461409
Homicide	35.41	21.89	11	27082	374	63461555
Mobility decreased	35.06	21.89	5	27088	121154	63340775
Acute hepatic failure	34.77	21.89	41	27052	18286	63443643
Aspiration	34.50	21.89	32	27061	10819	63451110
Urticaria	34.13	21.89	14	27079	165788	63296141
Encephalopathy	34.05	21.89	60	27033	38560	63423369
Febrile neutropenia	34.02	21.89	5	27088	118444	63343485
Hypertrophic scar	33.97	21.89	6	27087	12	63461917
Blister	33.96	21.89	7	27086	129807	63332122
Respiratory depression	33.46	21.89	35	27058	13680	63448249
Liver injury	32.99	21.89	77	27016	60443	63401486
Protein C increased	32.53	21.89	8	27085	111	63461818
Injection site pain	31.95	21.89	8	27085	129792	63332137
Abdominal pain upper	31.68	21.89	25	27068	206419	63255510
Accidental overdose	31.39	21.89	44	27049	23265	63438664
Drug abuser	31.30	21.89	18	27075	2905	63459024
Drug level increased	30.74	21.89	43	27050	22693	63439236
Loss of personal independence in daily activities	30.66	21.89	3	27090	97287	63364642
Haemoglobin decreased	30.41	21.89	12	27081	145473	63316456
Impaired healing	30.22	21.89	4	27089	102538	63359391
General physical health deterioration	30.14	21.89	25	27068	201377	63260552
Wheezing	29.99	21.89	3	27090	95592	63366337
Pulmonary congestion	29.83	21.89	37	27056	17381	63444548
Blood pressure increased	29.79	21.89	16	27077	162046	63299883
Shock	29.70	21.89	43	27050	23420	63438509
Amnesia	29.51	21.89	70	27023	55515	63406414
Environmental exposure	29.25	21.89	7	27086	86	63461843
Ventricular tachycardia	28.84	21.89	39	27054	19940	63441989
Brain death	28.74	21.89	18	27075	3392	63458537
Musculoskeletal pain	28.68	21.89	3	27090	92274	63369655
Bronchitis	28.34	21.89	9	27084	124926	63337003
Substance dependence	28.25	21.89	8	27085	196	63461733
Hepatic enzyme increased	28.02	21.89	27	27066	202301	63259628
Muscle spasms	27.86	21.89	16	27077	156134	63305795
COVID-19	27.78	21.89	7	27086	113096	63348833
Areflexia	27.65	21.89	17	27076	3101	63458828
Abdominal pain	27.63	21.89	52	27041	293404	63168525
Muscular weakness	27.42	21.89	9	27084	122344	63339585
Cardiogenic shock	27.41	21.89	36	27057	17896	63444033
Sepsis	26.88	21.89	16	27077	153107	63308822
Duodenal ulcer perforation	26.68	21.89	3	27090	87206	63374723
White blood cell count decreased	26.66	21.89	13	27080	139091	63322838
Induced abortion failed	26.58	21.89	8	27085	244	63461685
Dehydration	26.58	21.89	21	27072	173333	63288596
Psoriasis	26.58	21.89	3	27090	86954	63374975
Disinhibition	26.49	21.89	11	27082	872	63461057
Thrombocytopenia	26.24	21.89	16	27077	151141	63310788
Cerebrovascular accident	25.93	21.89	7	27086	108017	63353912
Pancytopenia	25.82	21.89	5	27088	96928	63365001
Gastrointestinal disorder	25.55	21.89	12	27081	131227	63330702
Pulmonary embolism	25.43	21.89	9	27084	116675	63345254
Product administration error	25.42	21.89	39	27054	22358	63439571
Gastrooesophageal reflux disease	25.34	21.89	5	27088	95634	63366295
Osteoarthritis	25.23	21.89	5	27088	95338	63366591
Toxicologic test abnormal	25.12	21.89	10	27083	711	63461218
Euphoric mood	25.07	21.89	19	27074	4868	63457061
Ventricular fibrillation	24.96	21.89	28	27065	11839	63450090
Congenital umbilical hernia	24.88	21.89	8	27085	305	63461624
Herpes zoster	24.82	21.89	3	27090	82459	63379470
Acidosis	24.47	21.89	27	27066	11206	63450723
Asthma	24.32	21.89	12	27081	127549	63334380
Visceral congestion	24.23	21.89	8	27085	332	63461597
Miosis	23.99	21.89	22	27071	7331	63454598
Vision blurred	23.95	21.89	5	27088	91919	63370010
Abnormal behaviour	23.88	21.89	37	27056	21389	63440540
Application site discolouration	23.87	21.89	10	27083	811	63461118
Pulmonary oedema	23.80	21.89	64	27029	54809	63407120
Alcohol withdrawal syndrome	23.80	21.89	10	27083	817	63461112
Gait disturbance	23.60	21.89	26	27067	183152	63278777
Deep vein thrombosis	23.02	21.89	4	27089	83796	63378133
C-reactive protein increased	22.99	21.89	6	27087	94701	63367228
Neuropathy peripheral	22.74	21.89	10	27083	113657	63348272
Irritable bowel syndrome	22.49	21.89	4	27089	82408	63379521
Inflammation	22.44	21.89	4	27089	82269	63379660
Ill-defined disorder	22.24	21.89	4	27089	81751	63380178
Alcoholic	22.11	21.89	5	27088	47	63461882

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	8511.95	24.95	3211	28576	95885	34829259
Completed suicide	7123.98	24.95	2819	28968	95349	34829795
Toxicity to various agents	5884.13	24.95	3058	28729	197304	34727840
Cardio-respiratory arrest	1680.18	24.95	873	30914	54400	34870744
Intentional product misuse	1130.96	24.95	630	31157	44981	34880163
Intentional overdose	1049.30	24.95	591	31196	43083	34882061
Poisoning	982.39	24.95	382	31405	11844	34913300
Respiratory arrest	966.48	24.95	483	31304	27560	34897584
Overdose	844.55	24.95	682	31105	90377	34834767
Cardiac arrest	602.98	24.95	577	31210	95582	34829562
Alcohol abuse	543.79	24.95	192	31595	4498	34920646
Suicide attempt	524.50	24.95	366	31421	38750	34886394
Alcohol interaction	519.82	24.95	165	31622	2748	34922396
Death	509.38	24.95	1114	30673	396935	34528209
Alcohol poisoning	458.47	24.95	158	31629	3435	34921709
Exposure via ingestion	432.82	24.95	134	31653	2047	34923097
Suspected suicide	351.66	24.95	140	31647	4608	34920536
Substance abuse	318.10	24.95	150	31637	7491	34917653
Drug dependence	313.62	24.95	222	31565	23995	34901149
Coma	268.42	24.95	265	31522	45413	34879731
Poisoning deliberate	251.84	24.95	129	31658	7715	34917429
Asphyxia	218.24	24.95	112	31675	6723	34918421
Alcohol use	216.12	24.95	89	31698	3199	34921945
Diarrhoea	208.08	24.95	50	31737	389862	34535282
Drug ineffective	200.44	24.95	83	31704	456668	34468476
Respiratory depression	198.94	24.95	144	31643	16101	34909043
Exposure to toxic agent	193.52	24.95	85	31702	3590	34921554
Pneumonia	177.44	24.95	55	31732	362572	34562572
Aggression	176.82	24.95	197	31590	38767	34886377
Blood alcohol increased	165.09	24.95	51	31736	772	34924372
Fatigue	156.58	24.95	71	31716	370582	34554562
Dyspnoea	148.81	24.95	79	31708	376703	34548441
Accidental death	133.19	24.95	58	31729	2398	34922746
Off label use	128.51	24.95	116	31671	419408	34505736
Anaemia	125.99	24.95	29	31758	233306	34691838
Pyrexia	121.19	24.95	77	31710	332936	34592208
Rash	119.63	24.95	28	31759	222724	34702420
Incorrect route of product administration	105.93	24.95	96	31691	14749	34910395
Intentional self-injury	100.12	24.95	90	31697	13681	34911463
Arthralgia	98.21	24.95	18	31769	170023	34755121
Febrile neutropenia	97.51	24.95	7	31780	136842	34788302
Pain	96.40	24.95	33	31754	204642	34720502
Substance use disorder	94.49	24.95	33	31754	746	34924398
Sepsis	91.24	24.95	20	31767	166541	34758603
Asthenia	90.07	24.95	56	31731	245195	34679949
Intentional product use issue	88.86	24.95	179	31608	59637	34865507
Cough	86.45	24.95	16	31771	150124	34775020
Nausea	86.07	24.95	110	31677	339798	34585346
Drug use disorder	85.14	24.95	51	31736	4140	34921004
Condition aggravated	83.79	24.95	35	31752	192161	34732983
Constipation	80.15	24.95	14	31773	136968	34788176
Neutropenia	79.68	24.95	22	31765	156756	34768388
Depressed level of consciousness	76.93	24.95	139	31648	42702	34882442
Suicidal ideation	76.32	24.95	134	31653	40254	34884890
Pain in extremity	76.08	24.95	12	31775	126501	34798643
Drug withdrawal syndrome	76.03	24.95	92	31695	19742	34905402
Miosis	74.66	24.95	65	31722	9470	34915674
Decreased appetite	74.63	24.95	29	31758	166363	34758781
Agitation	71.61	24.95	160	31627	57239	34867905
Prescription drug used without a prescription	70.78	24.95	36	31751	2118	34923026
Medication error	70.71	24.95	101	31686	25464	34899680
Pruritus	70.15	24.95	21	31766	141960	34783184
Drug screen positive	69.93	24.95	44	31743	3899	34921245
Mydriasis	68.39	24.95	55	31732	7182	34917962
Alcohol withdrawal syndrome	67.49	24.95	31	31756	1455	34923689
Weight decreased	66.42	24.95	39	31748	176262	34748882
Infection	63.74	24.95	5	31782	90910	34834234
Back pain	62.03	24.95	17	31770	121772	34803372
Oedema peripheral	60.50	24.95	17	31770	119795	34805349
White blood cell count decreased	59.82	24.95	8	31779	95437	34829707
Malignant neoplasm progression	58.60	24.95	6	31781	88040	34837104
Product dose omission issue	58.59	24.95	18	31769	119693	34805451
Environmental exposure	58.17	24.95	18	31769	274	34924870
General physical health deterioration	58.08	24.95	22	31765	128247	34796897
Unresponsive to stimuli	58.05	24.95	96	31691	27473	34897671
Pancytopenia	57.25	24.95	9	31778	95148	34829996
Pulmonary oedema	56.50	24.95	130	31657	47399	34877745
Sopor	56.09	24.95	62	31725	12074	34913070
Blood ethanol increased	56.02	24.95	20	31767	483	34924661
Dizziness	55.93	24.95	70	31717	218451	34706693
Alcohol intolerance	54.50	24.95	19	31768	427	34924717
Alcoholism	52.37	24.95	33	31754	2932	34922212
Accidental overdose	51.95	24.95	77	31710	20063	34905081
Peripheral swelling	51.50	24.95	5	31782	76536	34848608
Road traffic accident	49.81	24.95	70	31717	17380	34907764
Nasopharyngitis	48.61	24.95	4	31783	69964	34855180
Atrial fibrillation	47.60	24.95	26	31761	122367	34802777
Abdominal pain	46.64	24.95	48	31739	163570	34761574
Renal impairment	46.62	24.95	14	31773	94499	34830645
Tachycardia	46.54	24.95	176	31611	84596	34840548
Metabolic acidosis	46.00	24.95	114	31673	43566	34881578
Dehydration	45.82	24.95	31	31756	129938	34795206
Cardiac failure congestive	45.54	24.95	10	31777	83260	34841884
Malaise	44.99	24.95	62	31725	185763	34739381
Drug interaction	44.95	24.95	355	31432	225591	34699553
Headache	44.63	24.95	71	31716	200564	34724580
Cerebrovascular accident	42.86	24.95	12	31775	84799	34840345
Drug intolerance	42.53	24.95	3	31784	59567	34865577
Cardiac failure	42.39	24.95	15	31772	91233	34833911
Urinary tract infection	42.30	24.95	12	31775	84069	34841075
Drug abuser	41.56	24.95	32	31755	3922	34921222
Ex-drug abuser	41.55	24.95	12	31775	142	34925002
Haemoglobin decreased	40.99	24.95	30	31757	120742	34804402
Withdrawal syndrome	40.14	24.95	53	31734	12402	34912742
Myocardial infarction	39.91	24.95	31	31756	121054	34804090
Neuropathy peripheral	39.87	24.95	13	31774	83250	34841894
Respiratory tract infection bacterial	39.64	24.95	23	31764	1759	34923385
Erythema	38.90	24.95	16	31771	88764	34836380
Amnesia	38.82	24.95	79	31708	26484	34898660
Acute kidney injury	38.58	24.95	145	31642	304843	34620301
Loss of consciousness	38.45	24.95	163	31624	82504	34842640
Platelet count decreased	37.78	24.95	32	31755	119685	34805459
Homicide	37.55	24.95	18	31769	931	34924213
Chest pain	37.47	24.95	36	31751	126726	34798418
Muscular weakness	37.42	24.95	10	31777	72887	34852257
Brain oedema	37.32	24.95	54	31733	13767	34911377
Weight increased	37.29	24.95	19	31768	93014	34832130
Physical assault	37.22	24.95	19	31768	1126	34924018
Septic shock	36.60	24.95	10	31777	71824	34853320
Deep vein thrombosis	35.34	24.95	8	31779	65240	34859904
Neutrophil count decreased	35.28	24.95	3	31784	51101	34874043
Pleural effusion	35.24	24.95	15	31772	81531	34843613
Respiratory tract infection viral	34.70	24.95	24	31763	2493	34922651
Infusion related reaction	34.32	24.95	4	31783	53053	34872091
Chills	33.31	24.95	16	31771	81027	34844117
Hepatic fibrosis	33.26	24.95	30	31757	4577	34920567
Renal failure	33.17	24.95	42	31745	130515	34794629
Shock	33.09	24.95	70	31717	24109	34901035
Opiates positive	32.41	24.95	14	31773	567	34924577
Influenza	31.49	24.95	4	31783	49662	34875482
Thrombocytopenia	31.34	24.95	59	31728	156188	34768956
Myalgia	31.08	24.95	19	31768	84091	34841053
Blood ethanol	30.25	24.95	9	31778	119	34925025
Therapeutic product effect incomplete	29.89	24.95	5	31782	50536	34874608
Impaired driving ability	29.20	24.95	22	31765	2611	34922533
Foetal alcohol syndrome	29.14	24.95	9	31778	136	34925008
Haematochezia	28.90	24.95	4	31783	46530	34878614
Chronic obstructive pulmonary disease	28.58	24.95	5	31782	48913	34876231
Hypersensitivity	28.40	24.95	10	31777	61025	34864119
Leukopenia	28.06	24.95	11	31776	62845	34862299
Electrocardiogram QRS complex prolonged	27.96	24.95	28	31759	4866	34920278
Wheezing	27.08	24.95	3	31784	41399	34883745
Hospitalisation	27.03	24.95	9	31778	56893	34868251
Musculoskeletal stiffness	26.78	24.95	5	31782	46675	34878469
Self-medication	26.51	24.95	21	31766	2682	34922462
Toxicologic test abnormal	26.51	24.95	12	31775	544	34924600
Gun shot wound	26.27	24.95	15	31772	1113	34924031
Somnolence	26.25	24.95	182	31605	110934	34814210
Thrombosis	25.75	24.95	7	31780	50451	34874693
Myocardial fibrosis	25.44	24.95	15	31772	1182	34923962
Accidental poisoning	25.37	24.95	13	31774	777	34924367
Hyperkalaemia	25.18	24.95	16	31771	69373	34855771
Electrocardiogram repolarisation abnormality	25.14	24.95	14	31773	990	34924154
Pulmonary congestion	25.12	24.95	45	31742	13720	34911424

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	17487.24	21.50	6388	47340	239379	79451281
Drug abuse	12106.17	21.50	4393	49335	158298	79532362
Toxicity to various agents	11589.26	21.50	5579	48149	415961	79274699
Cardio-respiratory arrest	3884.14	21.50	1743	51985	106767	79583893
Respiratory arrest	2366.28	21.50	1021	52707	56529	79634131
Intentional overdose	2210.12	21.50	1179	52549	104781	79585879
Intentional product misuse	1930.75	21.50	1040	52688	94125	79596535
Poisoning	1900.43	21.50	694	53034	24578	79666082
Overdose	1810.59	21.50	1266	52462	182940	79507720
Cardiac arrest	1728.93	21.50	1199	52529	170897	79519763
Death	1708.96	21.50	1994	51734	564520	79126140
Alcohol interaction	876.16	21.50	259	53469	4615	79686045
Suicide attempt	868.65	21.50	594	53134	82338	79608322
Exposure via ingestion	758.53	21.50	235	53493	4939	79685721
Suspected suicide	690.15	21.50	262	53466	10314	79680346
Alcohol poisoning	690.06	21.50	215	53513	4606	79686054
Alcohol use	639.64	21.50	203	53525	4628	79686032
Alcohol abuse	547.03	21.50	185	53543	5178	79685482
Drug ineffective	458.15	21.50	88	53640	1080825	78609835
Coma	457.56	21.50	443	53285	100206	79590454
Exposure to toxic agent	423.53	21.50	177	53551	8981	79681679
Poisoning deliberate	403.73	21.50	214	53514	18614	79672046
Diarrhoea	361.51	21.50	77	53651	880412	78810248
Drug dependence	352.36	21.50	260	53468	40509	79650151
Substance abuse	352.16	21.50	162	53566	10364	79680296
Fatigue	310.51	21.50	120	53608	929607	78761053
Dyspnoea	292.12	21.50	107	53621	856918	78833742
Pain	289.69	21.50	61	53667	703741	78986919
Arthralgia	269.87	21.50	34	53694	571769	79118891
Off label use	265.51	21.50	141	53587	907074	78783586
Blood alcohol increased	264.43	21.50	76	53652	1219	79689441
Rash	255.24	21.50	42	53686	578316	79112344
Asphyxia	222.75	21.50	123	53605	11597	79679063
Pneumonia	212.21	21.50	90	53638	660156	79030504
Accidental death	198.60	21.50	83	53645	4208	79686452
Condition aggravated	196.78	21.50	48	53680	501076	79189584
Headache	196.30	21.50	98	53630	653674	79036986
Nausea	195.48	21.50	215	53513	956981	78733679
Pyrexia	191.68	21.50	110	53618	678599	79012061
Respiratory depression	188.07	21.50	153	53575	27477	79663183
Aggression	181.76	21.50	197	53531	50761	79639899
Intentional self-injury	180.63	21.50	160	53568	32259	79658401
Pain in extremity	175.92	21.50	20	53708	364518	79326142
Anaemia	172.00	21.50	44	53684	444971	79245689
Pruritus	170.96	21.50	30	53698	394618	79296042
Agitation	162.10	21.50	262	53466	99453	79591207
Joint swelling	161.27	21.50	8	53720	288638	79402022
Mydriasis	160.25	21.50	116	53612	17527	79673133
Asthenia	150.02	21.50	79	53649	511610	79179050
Cough	138.39	21.50	38	53690	366751	79323909
Drug intolerance	136.59	21.50	11	53717	264108	79426552
Drug use disorder	135.42	21.50	80	53648	8571	79682089
Peripheral swelling	134.64	21.50	13	53715	269604	79421056
Depressed level of consciousness	133.27	21.50	236	53492	96416	79594244
Infusion related reaction	129.82	21.50	6	53722	230231	79460429
Substance use disorder	126.56	21.50	40	53688	898	79689762
Malaise	126.27	21.50	88	53640	489781	79200879
Back pain	125.56	21.50	26	53702	304154	79386506
Nasopharyngitis	124.79	21.50	13	53715	253868	79436792
Urinary tract infection	122.97	21.50	19	53709	274493	79416167
Blood ethanol increased	120.90	21.50	36	53692	657	79690003
Weight decreased	119.47	21.50	45	53683	355153	79335507
Decreased appetite	119.21	21.50	41	53687	342377	79348283
Rheumatoid arthritis	118.95	21.50	5	53723	208465	79482195
Hypersensitivity	117.81	21.50	18	53710	262221	79428439
Somnolence	117.41	21.50	391	53337	238590	79452070
Dizziness	116.47	21.50	110	53618	526331	79164329
Febrile neutropenia	115.69	21.50	11	53717	230988	79459672
Constipation	115.17	21.50	25	53703	283025	79407635
Infection	114.71	21.50	14	53714	241698	79448962
Incorrect route of product administration	114.12	21.50	129	53599	34800	79655860
Neutropenia	113.88	21.50	27	53701	287683	79402977
Alopecia	113.30	21.50	12	53716	231343	79459317
Weight increased	111.84	21.50	25	53703	277361	79413299
Drug abuser	111.23	21.50	62	53666	5951	79684709
Unresponsive to stimuli	110.94	21.50	161	53567	55627	79635033
Drug hypersensitivity	108.97	21.50	33	53695	298883	79391777
Arthropathy	105.41	21.50	3	53725	177108	79513552
Miosis	104.42	21.50	86	53642	15703	79674957
Metabolic acidosis	102.96	21.50	193	53535	82336	79608324
Abdominal discomfort	100.27	21.50	23	53705	250704	79439956
Swelling	97.04	21.50	15	53713	216696	79473964
Loss of consciousness	96.38	21.50	290	53438	167653	79523007
Alcoholism	96.20	21.50	48	53680	3675	79686985
Sepsis	95.95	21.50	31	53697	269397	79421263
Product dose omission issue	94.52	21.50	25	53703	247512	79443148
General physical health deterioration	89.01	21.50	37	53691	275201	79415459
Electrocardiogram QRS complex prolonged	88.87	21.50	67	53661	10766	79679894
Environmental exposure	88.40	21.50	25	53703	377	79690283
Synovitis	88.08	21.50	3	53725	150731	79539929
Drug screen positive	86.95	21.50	53	53675	6010	79684650
Sinusitis	86.47	21.50	14	53714	195487	79495173
Pulmonary oedema	83.45	21.50	184	53544	88070	79602590
Tachycardia	82.97	21.50	286	53442	177482	79513178
Urticaria	82.50	21.50	13	53715	185188	79505472
Postmortem blood drug level abnormal	80.47	21.50	26	53702	628	79690032
Therapeutic product effect decreased	78.94	21.50	9	53719	163854	79526806
Medication error	78.82	21.50	155	53573	68487	79622173
Musculoskeletal stiffness	78.60	21.50	12	53716	174996	79515664
White blood cell count decreased	75.80	21.50	17	53711	188271	79502389
Therapeutic product effect incomplete	75.77	21.50	5	53723	141640	79549020
Abdominal pain	74.30	21.50	92	53636	389477	79301183
Chest pain	73.58	21.50	50	53678	282254	79408406
Pancytopenia	73.00	21.50	12	53716	165733	79524927
Suicidal ideation	71.99	21.50	159	53569	76181	79614479
Fall	71.18	21.50	138	53590	487491	79203169
Accidental overdose	69.79	21.50	108	53620	39473	79651187
Alcohol withdrawal syndrome	67.40	21.50	31	53697	1980	79688680
Prescription drug used without a prescription	67.16	21.50	39	53689	4046	79686614
Sopor	66.69	21.50	96	53632	32914	79657746
Drug interaction	65.39	21.50	491	53237	414692	79275968
Dehydration	64.61	21.50	44	53684	248143	79442517
Stomatitis	63.79	21.50	11	53717	146746	79543914
Muscular weakness	63.72	21.50	15	53713	160714	79529946
Asthma	63.63	21.50	8	53720	135087	79555573
Erythema	63.08	21.50	36	53692	223254	79467406
Drug withdrawal syndrome	62.99	21.50	96	53632	34622	79656038
Systemic lupus erythematosus	62.72	21.50	5	53723	121144	79569516
Intentional product use issue	62.67	21.50	235	53493	151877	79538783
Malignant neoplasm progression	61.80	21.50	9	53719	135981	79554679
Cardiac failure congestive	61.19	21.50	11	53717	142391	79548269
Shock	60.84	21.50	107	53621	43441	79647219
Cerebrovascular accident	60.57	21.50	15	53713	155277	79535383
Seizure	59.83	21.50	269	53459	188565	79502095
Homicide	58.46	21.50	24	53704	1162	79689498
Haemoglobin decreased	58.32	21.50	39	53689	222080	79468580
Mobility decreased	58.12	21.50	7	53721	122168	79568492
Pericarditis	57.81	21.50	3	53725	104233	79586427
Hand deformity	57.61	21.50	3	53725	103916	79586744
Wheezing	57.22	21.50	6	53722	116658	79574002
Chemical submission	56.60	21.50	17	53711	320	79690340
Oedema peripheral	56.52	21.50	52	53676	252236	79438424
Abdominal pain upper	55.22	21.50	42	53686	223777	79466883
Interstitial lung disease	54.69	21.50	6	53722	112594	79578066
Bronchitis	54.20	21.50	11	53717	130633	79560027
Injection site pain	53.73	21.50	11	53717	129827	79560833
Pulmonary congestion	53.55	21.50	78	53650	27022	79663638
Discomfort	53.33	21.50	10	53718	125607	79565053
Brain oedema	53.28	21.50	75	53653	25188	79665472
Electrocardiogram QT prolonged	52.67	21.50	157	53571	90229	79600431
Blood ethanol	52.23	21.50	14	53714	171	79690489
Blister	51.83	21.50	9	53719	119467	79571193
Opiates positive	51.82	21.50	21	53707	983	79689677
Arthritis	51.29	21.50	8	53720	114872	79575788
Loss of personal independence in daily activities	51.02	21.50	5	53723	102575	79588085
Herpes zoster	50.63	21.50	3	53725	93080	79597580
Blood pressure increased	50.45	21.50	41	53687	211319	79479341
Cellulitis	50.06	21.50	7	53721	109053	79581607
Leukopenia	50.05	21.50	9	53719	116504	79574156
Hypertension	49.71	21.50	92	53636	330900	79359760
Septic shock	49.59	21.50	11	53717	122790	79567870
Lower respiratory tract infection	49.39	21.50	13	53715	129207	79561453
Hypoaesthesia	49.12	21.50	30	53698	179322	79511338
Neuropathy peripheral	48.97	21.50	17	53711	141288	79549372
Acute kidney injury	48.57	21.50	183	53545	519221	79171439
Musculoskeletal pain	48.35	21.50	6	53722	102348	79588312
Renal impairment	48.16	21.50	23	53705	157760	79532900
Product use in unapproved indication	47.82	21.50	59	53669	250300	79440360
Influenza	47.75	21.50	14	53714	129592	79561068
Impaired healing	47.15	21.50	3	53725	87652	79603008
Sinus tachycardia	46.86	21.50	87	53641	36821	79653839
Product administration error	46.77	21.50	80	53648	31766	79658894
Deep vein thrombosis	46.53	21.50	12	53716	120907	79569753
Abdominal distension	45.80	21.50	12	53716	119638	79571022
Toxicologic test abnormal	45.69	21.50	21	53707	1339	79689321
Victim of sexual abuse	45.14	21.50	16	53712	516	79690144
Chills	45.01	21.50	26	53702	160208	79530452
Inappropriate schedule of product administration	44.74	21.50	17	53711	133611	79557049
Respiratory tract infection bacterial	42.79	21.50	23	53705	2054	79688606
Platelet count decreased	42.56	21.50	41	53687	194623	79496037
Myocardial infarction	42.36	21.50	37	53691	184092	79506568
Thrombocytopenia	42.29	21.50	71	53657	265188	79425472
Oropharyngeal pain	41.79	21.50	11	53717	109342	79581318
Haematochezia	41.73	21.50	5	53723	87640	79603020
Hepatic enzyme increased	41.65	21.50	37	53691	182573	79508087
Withdrawal syndrome	41.48	21.50	69	53659	26785	79663875
Injection site erythema	41.11	21.50	3	53725	78194	79612466
Inflammation	40.80	21.50	7	53721	93746	79596914
Gastrointestinal disorder	40.17	21.50	16	53712	122189	79568471
Nasal congestion	40.07	21.50	3	53725	76549	79614111
Productive cough	39.77	21.50	6	53722	88325	79602335
Amphetamines positive	39.66	21.50	13	53715	329	79690331
Mucosal inflammation	39.45	21.50	3	53725	75577	79615083
Postmortem blood drug level	39.44	21.50	13	53715	335	79690325
Stress	39.28	21.50	4	53724	79608	79611052
Osteoarthritis	39.15	21.50	6	53722	87303	79603357
Alcohol intolerance	38.93	21.50	14	53714	471	79690189
Neutrophil count decreased	38.79	21.50	8	53720	93951	79596709
Dysphagia	38.52	21.50	17	53711	122119	79568541
Acute hepatic failure	38.25	21.50	71	53657	30042	79660618
Drug level increased	37.84	21.50	83	53645	39568	79651092
Bezoar	37.27	21.50	23	53705	2665	79687995
Gastrooesophageal reflux disease	37.06	21.50	12	53716	104234	79586426
Contraindicated product administered	37.04	21.50	31	53697	157507	79533153
Congestive hepatopathy	37.02	21.50	28	53700	4519	79686141
Muscle spasms	36.82	21.50	38	53690	174692	79515968
Psoriasis	36.22	21.50	8	53720	89579	79601081
Dyspepsia	36.10	21.50	14	53714	108673	79581987
Pupil fixed	35.97	21.50	25	53703	3541	79687119
COVID-19	35.89	21.50	32	53696	157642	79533018
Chronic obstructive pulmonary disease	35.83	21.50	7	53721	85412	79605248
Oedema	35.63	21.50	18	53710	119562	79571098
Hepatic failure	35.34	21.50	106	53622	61106	79629554
Hospitalisation	35.04	21.50	10	53718	94226	79596434
Hypotension	34.80	21.50	451	53277	439866	79250794
Road traffic accident	34.63	21.50	85	53643	43579	79647081
Angioedema	34.61	21.50	5	53723	76030	79614630
Neck pain	34.24	21.50	5	53723	75412	79615248
Chest discomfort	33.91	21.50	26	53702	138018	79552642
Physical assault	33.64	21.50	18	53710	1593	79689067
Brain death	33.58	21.50	29	53699	5648	79685012
Gait disturbance	33.56	21.50	55	53673	207451	79483209
Psoriatic arthropathy	33.55	21.50	6	53722	77993	79612667
Acidosis	33.55	21.50	53	53675	19709	79670951
Victim of chemical submission	33.53	21.50	13	53715	541	79690119
Duodenal ulcer perforation	33.53	21.50	3	53725	66208	79624452
Somnambulism	33.38	21.50	29	53699	5692	79684968
Pulmonary embolism	33.24	21.50	40	53688	171614	79519046
Accidental poisoning	33.16	21.50	18	53710	1639	79689021
Migraine	33.06	21.50	9	53719	87484	79603176
Colitis	32.96	21.50	5	53723	73302	79617358
Myocardial fibrosis	32.55	21.50	18	53710	1700	79688960
Accidental exposure to product	31.53	21.50	67	53661	31255	79659405
Vision blurred	31.46	21.50	16	53712	105882	79584778
Paraesthesia	31.15	21.50	44	53684	176279	79514381
Thrombosis	31.13	21.50	9	53719	84091	79606569
Hepatic fibrosis	31.07	21.50	31	53697	7249	79683411
Insomnia	31.04	21.50	75	53653	245095	79445565
Dyspnoea exertional	31.00	21.50	10	53718	87063	79603597
Cataract	30.96	21.50	3	53725	62117	79628543
Anaphylactic reaction	30.92	21.50	9	53719	83734	79606926
Electrocardiogram ST segment elevation	30.86	21.50	33	53695	8364	79682296
Amnesia	30.73	21.50	103	53625	62954	79627706
Maternal exposure during pregnancy	30.73	21.50	28	53700	136510	79554150
Liver disorder	30.23	21.50	6	53722	72411	79618249
Aspiration	30.07	21.50	51	53677	20107	79670553
Upper respiratory tract infection	29.85	21.50	12	53716	91156	79599504
Respiratory tract infection viral	29.85	21.50	24	53704	4235	79686425
Fibromyalgia	29.83	21.50	4	53724	64336	79626324
Rheumatoid factor positive	29.54	21.50	3	53725	59836	79630824
Respiratory acidosis	29.38	21.50	37	53691	11163	79679497
Therapeutic response decreased	29.07	21.50	5	53723	66848	79623812
Therapy non-responder	28.87	21.50	13	53715	92292	79598368
Visual impairment	28.77	21.50	13	53715	92118	79598542
Rectal haemorrhage	28.54	21.50	8	53720	76292	79614368
Wound	28.38	21.50	22	53706	116157	79574503
Hyponatraemia	27.96	21.50	48	53680	177800	79512860
Dysgeusia	27.88	21.50	3	53725	57174	79633486
Influenza like illness	27.81	21.50	7	53721	71700	79618960
Substance dependence	27.60	21.50	11	53717	493	79690167
Hypertrophic scar	27.58	21.50	5	53723	6	79690654
Hyperkalaemia	27.52	21.50	22	53706	114376	79576284
Myalgia	27.49	21.50	52	53676	185589	79505071
Epistaxis	27.39	21.50	21	53707	111494	79579166
Blood pressure systolic increased	27.04	21.50	6	53722	66980	79623680
Cardiac failure	26.99	21.50	39	53689	154803	79535857
Syncope	26.80	21.50	50	53678	179399	79511261
Fluid retention	26.71	21.50	7	53721	69802	79620858
Delirium tremens	26.70	21.50	12	53716	726	79689934
Suicidal behaviour	26.45	21.50	20	53708	3227	79687433
Irritable bowel syndrome	26.31	21.50	5	53723	62236	79628424
Atrial fibrillation	26.28	21.50	59	53669	197827	79492833
Bradypnoea	26.25	21.50	26	53702	6026	79684634
Euphoric mood	26.02	21.50	29	53699	7697	79682963
Osteoporosis	25.98	21.50	3	53725	54109	79636551
Self-medication	25.96	21.50	24	53704	5108	79685552
Blood cholesterol increased	25.85	21.50	12	53716	83708	79606952
Rash erythematous	25.83	21.50	4	53724	57765	79632895
Type 2 diabetes mellitus	25.44	21.50	4	53724	57118	79633542
Renal failure	25.02	21.50	62	53666	200906	79489754
Coma scale abnormal	24.91	21.50	30	53698	8648	79682012
Impaired driving ability	24.86	21.50	24	53704	5391	79685269
Protein C increased	24.85	21.50	7	53721	104	79690556
Diabetes mellitus	24.57	21.50	11	53717	78379	79612281
Ill-defined disorder	24.47	21.50	7	53721	65868	79624792
Hypothermia	24.46	21.50	50	53678	22696	79667964
Gait inability	24.35	21.50	5	53723	58912	79631748
Drug ineffective for unapproved indication	24.20	21.50	3	53725	51235	79639425
Bone marrow failure	24.12	21.50	3	53725	51104	79639556
Feeling abnormal	24.09	21.50	44	53684	159155	79531505
C-reactive protein increased	24.00	21.50	31	53697	128996	79561664
Exposure via inhalation	23.86	21.50	7	53721	121	79690539
Skin ulcer	23.65	21.50	4	53724	54146	79636514
Sudden death	23.64	21.50	49	53679	22462	79668198
Contusion	23.53	21.50	40	53688	148736	79541924
Pneumonitis	23.48	21.50	6	53722	60854	79629806
Drug diversion	23.42	21.50	13	53715	1237	79689423
Dysarthria	23.42	21.50	99	53629	67523	79623137
Ascites	23.07	21.50	11	53717	75551	79615109
Multiple injuries	23.03	21.50	19	53709	3476	79687184
Pleural effusion	23.02	21.50	39	53689	145223	79545437
Palpitations	22.95	21.50	31	53697	126579	79564081
Abnormal behaviour	22.87	21.50	65	53663	36356	79654304
Alcoholic liver disease	22.75	21.50	10	53718	574	79690086
Cardiac disorder	22.62	21.50	8	53720	65749	79624911
Hypothyroidism	22.60	21.50	4	53724	52388	79638272
Areflexia	22.58	21.50	23	53705	5511	79685149
Bone pain	22.48	21.50	5	53723	55737	79634923
Pulmonary hypertension	22.26	21.50	3	53725	48077	79642583
Rhabdomyolysis	22.23	21.50	132	53596	102999	79587661
Haematocrit decreased	21.89	21.50	7	53721	61305	79629355
Behaviour disorder	21.79	21.50	24	53704	6289	79684371
Injection site swelling	21.69	21.50	3	53725	47129	79643531
Generalised tonic-clonic seizure	21.64	21.50	72	53656	43838	79646822

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AB02	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment
ATC	D08AX01	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Other antiseptics and disinfectants
ATC	D11AX25	DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals
ATC	S02AA06	SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local
MeSH PA	D009676	Noxae
MeSH PA	D016877	Oxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:33281	antibiotics
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:50902	genotoxic agent
CHEBI has role	CHEBI:50910	agente neurotoxico
CHEBI has role	CHEBI:59163	biological marker
CHEBI has role	CHEBI:63248	oxidizer
CHEBI has role	CHEBI:63490	explosive compounds
CHEBI has role	CHEBI:65259	GABA antagonists
CHEBI has role	CHEBI:68495	Type I cell-death inducers
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:149552	emetics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Antiseptic preparation	indication	261276004

🐶 Veterinary Drug Use

Species	Use	Relation
Fish	Control mortality caused by saprolegniasis	Indication
Fish	Control mortality caused by bacterial gill disease associated with Flavobacterium branchiophilum	Indication
Fish	Control mortality caused by saprolegniasis	Indication
Fish	Control mortality caused by external columnaris disease associated with Flavobacterium columnare (Flexibacter columnaris)	Indication
Fish	Control mortality caused by external columnaris disease associated with Flavobacterium columnare (Flexibacter columnaris)	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
35% PEROX-AID	Syndel USA	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.99	acidic
pKa2	12.0	acidic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
40%	ESKATA	ACLARIS	N209305	Dec. 14, 2017	DISCN	SOLUTION	TOPICAL	10098910	April 21, 2035	TREATMENT OF SEBORRHEIC KERATOSES THAT ARE RAISED
40%	ESKATA	ACLARIS	N209305	Dec. 14, 2017	DISCN	SOLUTION	TOPICAL	9980983	April 21, 2035	TREATMENT OF SEBORRHEIC KERATOSES THAT ARE RAISED
40%	ESKATA	ACLARIS	N209305	Dec. 14, 2017	DISCN	SOLUTION	TOPICAL	9675639	July 4, 2035	TREATMENT OF SEBORRHEIC KERATOSES THAT ARE RAISED

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
BBX060AN9V	UNII
D00008	KEGG_DRUG
4019590	VANDF
C0020281	UMLSCUI
CHEBI:16240	CHEBI
PEO	PDB_CHEM_ID
CHEMBL71595	ChEMBL_ID
784	PUBCHEM_CID
DB11091	DRUGBANK_ID
D006861	MESH_DESCRIPTOR_UI
372426	RXNORM
35389	MMSL
35390	MMSL
4847	MMSL
5359	MMSL
003157	NDDF
31231007	SNOMEDCT_US
387171003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
PEROXYL MOUTH SORE MILD MINT	HUMAN OTC DRUG LABEL	1	0126-0083	RINSE	15 mg	BUCCAL	OTC MONOGRAPH NOT FINAL	13 sections
PEROXYL MOUTH SORE MILD MINT	HUMAN OTC DRUG LABEL	1	0126-0083	RINSE	15 mg	BUCCAL	OTC MONOGRAPH NOT FINAL	13 sections
Sore Mouth Cleanser	HUMAN OTC DRUG LABEL	1	0363-0085	MOUTHWASH	15 mg	TOPICAL	OTC monograph not final	12 sections
Sore Mouth Cleanser	HUMAN OTC DRUG LABEL	1	0363-0085	MOUTHWASH	1588 mg	TOPICAL	OTC monograph not final	12 sections
Sore Mouth Cleanser	HUMAN OTC DRUG LABEL	1	0363-0085	MOUTHWASH	1588 mg	TOPICAL	OTC monograph not final	12 sections
Hydrogen Peroxide3 Percent	HUMAN OTC DRUG LABEL	1	0363-0267	LIQUID	2.65 mL	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Hydrogen Peroxide3 Percent	HUMAN OTC DRUG LABEL	1	0363-0267	LIQUID	2.65 mL	TOPICAL	OTC MONOGRAPH NOT FINAL	13 sections
Hydrogen Peroxide3 Percent	HUMAN OTC DRUG LABEL	1	0363-0268	LIQUID	2.65 mL	TOPICAL	OTC monograph not final	13 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0363-0871	SOLUTION	30 mg	TOPICAL	OTC monograph not final	12 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0363-0871	SOLUTION	30 mg	TOPICAL	OTC monograph not final	12 sections
Oral Sore Antiseptic	HUMAN OTC DRUG LABEL	2	0363-1045	LIQUID	1.50 mg	ORAL	OTC monograph not final	13 sections
Oral Sore Antiseptic	HUMAN OTC DRUG LABEL	2	0363-1045	LIQUID	1.50 mg	ORAL	OTC monograph not final	13 sections
Humco Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0395-1113	LIQUID	30 mg	TOPICAL	OTC monograph not final	12 sections
Humco Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0395-1113	LIQUID	30 mg	TOPICAL	OTC monograph not final	12 sections
Humco Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0395-9116	LIQUID	30 mg	TOPICAL	OTC monograph not final	12 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0404-0001	SOLUTION	30 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0404-0001	SOLUTION	30 mg	TOPICAL	OTC MONOGRAPH NOT FINAL	14 sections
Henry Schein Mouth	HUMAN OTC DRUG LABEL	1	0404-0012	RINSE	1.50 mL	ORAL	OTC monograph not final	12 sections
Sore Mouth Cleanser	HUMAN OTC DRUG LABEL	1	0869-0462	MOUTHWASH	1588 mg	TOPICAL	OTC monograph not final	12 sections
Sore Mouth Cleanser	HUMAN OTC DRUG LABEL	1	0869-0462	MOUTHWASH	1588 mg	TOPICAL	OTC monograph not final	12 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0869-0871	SOLUTION	30 mg	TOPICAL	OTC monograph not final	13 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0869-0871	SOLUTION	30 mg	TOPICAL	OTC monograph not final	13 sections
Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0869-0871	SOLUTION	30 mg	TOPICAL	OTC monograph not final	13 sections
First Aid Only Hydrogen Peroxide	HUMAN OTC DRUG LABEL	1	0924-0171	SPRAY	30 mL	TOPICAL	OTC monograph not final	11 sections
Hydrogen Peroxide Antiseptic	HUMAN OTC DRUG LABEL	1	0924-0932	SPRAY	30 mL	TOPICAL	OTC monograph not final	11 sections
First Aid Only Hydrogen Peroxide 3%	HUMAN OTC DRUG LABEL	1	0924-0935	SPRAY	30 mg	TOPICAL	OTC monograph not final	13 sections
Perio Armor	HUMAN OTC DRUG LABEL	1	10129-018	GEL	17 g	DENTAL	OTC monograph not final	12 sections
Perio Armor	HUMAN OTC DRUG LABEL	1	10129-019	GEL	17 g	DENTAL	OTC monograph not final	12 sections
Perio Armor	HUMAN OTC DRUG LABEL	1	10129-020	GEL	17 g	DENTAL	OTC monograph not final	12 sections
Perio Armor	HUMAN OTC DRUG LABEL	1	10129-032	GEL	17 g	DENTAL	OTC monograph not final	12 sections