hydrogen peroxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3281 7722-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxydol
  • hydrogen peroxide topical solution
  • hydrogen peroxide
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
  • Molecular weight: 34.01
  • Formula: H2O2
  • CLOGP:
  • LIPINSKI: None
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS:
  • ROTB: 0

Drug dosage:

DoseUnitRoute
60 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4697.31 25.94 1724 12764 144196 46527378
Toxicity to various agents 2983.48 25.94 1391 13097 210375 46461199
Drug abuse 1096.51 25.94 485 14003 62923 46608651
Intentional overdose 1078.94 25.94 483 14005 64461 46607113
Cardio-respiratory arrest 951.78 25.94 432 14056 59437 46612137
Overdose 758.27 25.94 441 14047 101538 46570036
Suicide attempt 697.68 25.94 340 14148 54696 46616878
Alcohol interaction 428.64 25.94 108 14380 2337 46669237
Suspected suicide 275.23 25.94 88 14400 4573 46667001
Intentional product misuse 274.88 25.94 175 14313 46953 46624621
Alcohol poisoning 252.85 25.94 70 14418 2198 46669376
Respiratory arrest 249.52 25.94 146 14342 33670 46637904
Alcohol use 229.72 25.94 66 14422 2376 46669198
Cardiac arrest 216.02 25.94 197 14291 90202 46581372
Coma 187.99 25.94 151 14337 58198 46613376
Somnolence 175.81 25.94 229 14259 156292 46515282
Alcohol abuse 174.74 25.94 52 14436 2120 46669454
Death 164.81 25.94 337 14151 335211 46336363
Drug ineffective 119.20 25.94 32 14456 677806 45993768
Loss of consciousness 93.82 25.94 140 14348 108098 46563476
Blood alcohol increased 87.58 25.94 24 14464 724 46670850
Poisoning deliberate 85.42 25.94 44 14444 7882 46663692
Mydriasis 84.22 25.94 48 14440 10505 46661069
Alcoholism 83.96 25.94 30 14458 2188 46669386
Diarrhoea 81.67 25.94 36 14452 559566 46112008
Intentional self-injury 80.83 25.94 64 14424 24102 46647472
Exposure to toxic agent 71.58 25.94 26 14462 1988 46669586
Substance abuse 68.81 25.94 31 14457 4136 46667438
Agitation 68.18 25.94 85 14403 55330 46616244
Dyspnoea 67.88 25.94 38 14450 515510 46156064
Arthralgia 64.24 25.94 17 14471 364586 46306988
Pneumonia 63.61 25.94 19 14469 376301 46295273
Pain 60.14 25.94 37 14451 476911 46194663
Aggression 58.98 25.94 52 14436 22692 46648882
Drug withdrawal syndrome 58.17 25.94 56 14432 27328 46644246
Fatigue 57.27 25.94 63 14425 608634 46062940
Victim of sexual abuse 56.89 25.94 16 14472 532 46671042
Suicidal ideation 54.72 25.94 77 14411 56305 46615269
Rash 53.37 25.94 22 14466 356490 46315084
Drug dependence 52.60 25.94 46 14442 19855 46651719
Postmortem blood drug level abnormal 50.16 25.94 13 14475 315 46671259
Headache 48.92 25.94 46 14442 478306 46193268
Liver injury 48.46 25.94 40 14448 15961 46655613
Seizure 47.97 25.94 113 14375 122941 46548633
Pain in extremity 47.58 25.94 11 14477 258669 46412905
Drug use disorder 47.24 25.94 21 14467 2714 46668860
Pruritus 45.18 25.94 10 14478 242342 46429232
Poisoning 44.52 25.94 36 14452 13958 46657616
Somnambulism 43.13 25.94 24 14464 5013 46666561
Anaemia 43.01 25.94 13 14475 255766 46415808
Back pain 42.68 25.94 7 14481 210032 46461542
Electrocardiogram QT prolonged 42.42 25.94 65 14423 51260 46620314
Depressed level of consciousness 41.81 25.94 62 14426 47507 46624067
Tachycardia 41.59 25.94 94 14394 99528 46572046
Joint swelling 40.09 25.94 3 14485 166070 46505504
Urinary tract infection 39.25 25.94 10 14478 220256 46451318
Sopor 39.21 25.94 39 14449 19789 46651785
Nausea 38.79 25.94 99 14389 687355 45984219
Condition aggravated 38.49 25.94 14 14474 245038 46426536
Myocarditis 38.35 25.94 26 14462 7713 46663861
Hypertrophic scar 38.31 25.94 6 14482 6 46671568
Electrocardiogram QRS complex prolonged 36.15 25.94 22 14466 5427 46666147
Asthenia 35.30 25.94 27 14461 311048 46360526
Pyrexia 35.06 25.94 34 14454 348768 46322806
Amnesia 33.38 25.94 52 14436 41579 46629995
Drug interaction 33.37 25.94 138 14350 202956 46468618
Homicide 32.94 25.94 10 14478 436 46671138
Drug hypersensitivity 31.93 25.94 18 14470 243807 46427767
Metabolic acidosis 31.88 25.94 49 14439 38731 46632843
Alopecia 31.70 25.94 6 14482 162408 46509166
Product dose omission issue 31.29 25.94 7 14481 168513 46503061
Off label use 30.71 25.94 44 14444 379797 46291777
Peripheral swelling 30.51 25.94 6 14482 158065 46513509
Drug intolerance 29.64 25.94 5 14483 147044 46524530
Chemical submission 29.10 25.94 8 14480 244 46671330
Asphyxia 29.06 25.94 19 14469 5307 46666267
Cough 28.74 25.94 18 14470 230231 46441343
Abnormal behaviour 28.63 25.94 34 14454 21024 46650550
Neutropenia 28.57 25.94 5 14483 143199 46528375
Accidental death 28.24 25.94 13 14475 1822 46669752
Sinus tachycardia 27.88 25.94 34 14454 21615 46649959
Application site discolouration 27.28 25.94 10 14478 784 46670790
Constipation 27.23 25.94 10 14478 174087 46497487
Protein C increased 27.07 25.94 7 14481 168 46671406
Weight increased 26.48 25.94 9 14479 164464 46507110

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2998.89 22.71 1264 15746 80808 29854660
Completed suicide 2918.48 22.71 1312 15698 98180 29837288
Toxicity to various agents 2805.37 22.71 1533 15477 175650 29759818
Intentional overdose 786.37 22.71 409 16601 41072 29894396
Cardio-respiratory arrest 640.10 22.71 400 16610 56906 29878562
Overdose 606.28 22.71 448 16562 83889 29851579
Alcohol abuse 554.48 22.71 179 16831 5174 29930294
Suicide attempt 525.90 22.71 301 16709 36396 29899072
Intentional product misuse 427.20 22.71 258 16752 34409 29901059
Alcohol interaction 425.19 22.71 125 16885 2617 29932851
Alcohol poisoning 260.26 22.71 93 16917 3671 29931797
Suspected suicide 252.64 22.71 87 16923 3074 29932394
Substance abuse 252.32 22.71 108 16902 6932 29928536
Drug dependence 210.54 22.71 138 16872 21157 29914311
Alcohol use 180.16 22.71 71 16939 3684 29931784
Respiratory arrest 150.32 22.71 128 16882 29130 29906338
Coma 141.89 22.71 143 16867 40306 29895162
Aggression 135.94 22.71 134 16876 36773 29898695
Poisoning deliberate 122.33 22.71 62 16948 5842 29929626
Asphyxia 118.36 22.71 59 16951 5366 29930102
Incorrect route of product administration 113.40 22.71 74 16936 11241 29924227
Respiratory depression 109.86 22.71 73 16937 11430 29924038
Intentional product use issue 103.19 22.71 115 16895 36325 29899143
Blood alcohol increased 99.86 22.71 32 16978 899 29934569
Pneumonia 98.10 22.71 34 16976 334272 29601196
Cardiac arrest 91.75 22.71 178 16832 92672 29842796
Diarrhoea 91.31 22.71 38 16972 334065 29601403
Anaemia 83.77 22.71 10 17000 207982 29727486
Intentional self-injury 83.71 22.71 66 16944 13466 29922002
Drug withdrawal syndrome 82.49 22.71 77 16933 19732 29915736
Sopor 82.11 22.71 60 16950 10931 29924537
Pyrexia 79.60 22.71 34 16976 294455 29641013
Drug ineffective 79.06 22.71 48 16962 340339 29595129
Poisoning 78.01 22.71 59 16951 11323 29924145
Alcohol withdrawal syndrome 75.29 22.71 30 16980 1601 29933867
Suicidal ideation 71.31 22.71 95 16915 36019 29899449
Dyspnoea 62.01 22.71 59 16951 333236 29602232
Rash 60.64 22.71 17 16993 191872 29743596
Road traffic accident 55.52 22.71 58 16952 17013 29918455
Fatigue 54.83 22.71 61 16949 320612 29614856
Accidental death 52.52 22.71 25 16985 2054 29933414
Drug screen positive 49.54 22.71 31 16979 4376 29931092
Alcoholism 48.72 22.71 28 16982 3386 29932082
Febrile neutropenia 48.67 22.71 3 17007 106690 29828778
Amnesia 48.02 22.71 64 16946 24257 29911211
Neutropenia 47.43 22.71 8 17002 128532 29806936
Sepsis 44.34 22.71 14 16996 146381 29789087
Medication error 44.21 22.71 57 16953 20915 29914553
Ex-drug abuser 43.24 22.71 12 16998 202 29935266
Alcohol intolerance 42.62 22.71 14 16996 426 29935042
Somnolence 42.39 22.71 136 16874 96627 29838841
Miosis 41.90 22.71 35 16975 7741 29927727
Death 40.57 22.71 343 16667 356940 29578528
Cough 39.89 22.71 11 16999 125631 29809837
Hepatic fibrosis 39.78 22.71 25 16985 3555 29931913
Drug use disorder 39.44 22.71 24 16986 3224 29932244
Platelet count decreased 38.28 22.71 7 17003 106122 29829346
Pruritus 38.18 22.71 10 17000 118194 29817274
Haemoglobin decreased 38.12 22.71 9 17001 114089 29821379
Asthenia 37.85 22.71 42 16968 221248 29714220
Arthralgia 37.67 22.71 15 16995 135776 29799692
Agitation 37.59 22.71 90 16920 53983 29881485
Drug abuser 37.41 22.71 26 16984 4375 29931093
Pain 36.37 22.71 27 16983 172614 29762854
Exposure to toxic agent 36.18 22.71 16 16994 1109 29934359
Depressed level of consciousness 36.11 22.71 72 16938 38150 29897318
Constipation 35.62 22.71 10 17000 112896 29822572
Homicide 34.03 22.71 15 16995 1031 29934437
White blood cell count decreased 33.82 22.71 4 17006 83943 29851525
Drug interaction 33.13 22.71 210 16800 199358 29736110
Condition aggravated 32.49 22.71 19 16991 137847 29797621
Tachycardia 30.79 22.71 102 16908 73637 29861831
Loss of consciousness 30.69 22.71 107 16903 79268 29856200
Off label use 30.26 22.71 60 16950 249230 29686238
Metabolic acidosis 30.06 22.71 66 16944 37395 29898073
Foetal alcohol syndrome 30.04 22.71 9 17001 201 29935267
Decreased appetite 29.61 22.71 25 16985 149885 29785583
Pain in extremity 29.23 22.71 13 16997 110208 29825260
Impaired driving ability 29.03 22.71 18 16992 2500 29932968
Back pain 28.99 22.71 11 16999 102585 29832883
Physical assault 28.86 22.71 14 16996 1199 29934269
Pancytopenia 27.83 22.71 7 17003 85045 29850423
Shock 27.79 22.71 48 16962 22811 29912657
Malignant neoplasm progression 27.78 22.71 4 17006 72283 29863185
Product dose omission issue 27.30 22.71 9 17001 91622 29843846
General physical health deterioration 26.17 22.71 12 16998 99932 29835536
Gun shot wound 26.04 22.71 13 16997 1185 29934283
Oedema peripheral 25.77 22.71 14 16996 105818 29829650
Cardiac failure 25.19 22.71 8 17002 83410 29852058
Abnormal behaviour 25.08 22.71 49 16961 25574 29909894
Nausea 24.93 22.71 86 16924 296871 29638597
Atrial fibrillation 23.95 22.71 16 16994 108108 29827360
Mydriasis 23.88 22.71 23 16987 6120 29929348
Dysarthria 23.64 22.71 53 16957 30437 29905031
Myocardial infarction 23.53 22.71 22 16988 125603 29809865
Thrombocytopenia 23.40 22.71 26 16984 137018 29798450
Weight decreased 23.27 22.71 31 16979 150890 29784578
Bezoar 23.06 22.71 11 16999 908 29934560
Abdominal pain 22.87 22.71 26 16984 135628 29799840
Dextrocardia 22.81 22.71 7 17003 170 29935298
Somnambulism 22.77 22.71 17 16993 3197 29932271

Pharmacologic Action:

SourceCodeDescription
ATC A01AB02 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC D08AX01 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC D11AX25 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC S02AA06 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D009676 Noxae
MeSH PA D016877 Oxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:48219 disinfectants
CHEBI has role CHEBI:50902 genotoxic agent
CHEBI has role CHEBI:50910 agente neurotoxico
CHEBI has role CHEBI:59163 biological marker
CHEBI has role CHEBI:63248 oxidizing agent
CHEBI has role CHEBI:63490 explosive material
CHEBI has role CHEBI:65259 gamma-aminobutyric acid receptor antagonists
CHEBI has role CHEBI:68495 type i programmed cell-death inducer
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolites
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:149552 emetics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.99 acidic
pKa2 12.0 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00008 KEGG_DRUG
4019590 VANDF
C0020281 UMLSCUI
CHEBI:16240 CHEBI
PEO PDB_CHEM_ID
CHEMBL71595 ChEMBL_ID
DB11091 DRUGBANK_ID
D006861 MESH_DESCRIPTOR_UI
BBX060AN9V UNII
784 PUBCHEM_CID
372426 RXNORM
35389 MMSL
35390 MMSL
4847 MMSL
5359 MMSL
003157 NDDF
31231007 SNOMEDCT_US
387171003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PEROXYL MOUTH SORE MILD MINT HUMAN OTC DRUG LABEL 1 0126-0083 RINSE 15 mg BUCCAL OTC MONOGRAPH NOT FINULLL 13 sections
PEROXYL MOUTH SORE MILD MINT HUMAN OTC DRUG LABEL 1 0126-0083 RINSE 15 mg BUCCAL OTC MONOGRAPH NOT FINULLL 13 sections
Sore Mouth Cleanser HUMAN OTC DRUG LABEL 1 0363-0085 MOUTHWASH 1588 mg TOPICAL OTC monograph not final 10 sections
Hydrogen Peroxide3 Percent HUMAN OTC DRUG LABEL 1 0363-0267 LIQUID 2.65 mL TOPICAL OTC MONOGRAPH NOT FINULLL 13 sections
Hydrogen Peroxide3 Percent HUMAN OTC DRUG LABEL 1 0363-0268 LIQUID 2.65 mL TOPICAL OTC MONOGRAPH NOT FINULLL 13 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0363-0871 SOLUTION 30 mg TOPICAL OTC monograph not final 12 sections
Oral Sore Antiseptic HUMAN OTC DRUG LABEL 2 0363-1045 LIQUID 1.50 mg ORAL OTC monograph not final 12 sections
Humco Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0395-1113 LIQUID 30 mg TOPICAL OTC monograph not final 12 sections
Humco Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0395-9116 LIQUID 30 mg TOPICAL OTC monograph not final 12 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0404-0001 SOLUTION 30 mg TOPICAL OTC MONOGRAPH NOT FINULLL 14 sections
Sore Mouth Cleanser HUMAN OTC DRUG LABEL 1 0869-0462 MOUTHWASH 1588 mg TOPICAL OTC monograph not final 12 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0869-0871 SOLUTION 30 mg TOPICAL OTC monograph not final 12 sections
First Aid Only Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 0924-0171 SPRAY 30 mL TOPICAL OTC monograph not final 11 sections
Hydrogen Peroxide Antiseptic HUMAN OTC DRUG LABEL 1 0924-0932 SPRAY 30 mL TOPICAL OTC monograph not final 11 sections
MedPak Peroxide Oral Rinse HUMAN OTC DRUG LABEL 1 10031-008 LIQUID 15 mg ORAL OTC monograph not final 12 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 10202-001 SOLUTION 30 mg TOPICAL OTC MONOGRAPH NOT FINULLL 13 sections
Orajel Alcohol Free Antiseptic RinseFor All Mouth Sores HUMAN OTC DRUG LABEL 2 10237-759 LIQUID 1.50 mL ORAL OTC monograph not final 11 sections
Orajel Antiseptic RinseFor All Mouth Sores HUMAN OTC DRUG LABEL 2 10237-760 LIQUID 1.50 mL ORAL OTC monograph not final 11 sections
Orajel Antiseptic Alcohol-Free Mouth Sore Rinse HUMAN OTC DRUG LABEL 2 10237-784 LIQUID 1.50 mg ORAL OTC monograph not final 11 sections
Orajel Antiseptic Rinse for Mouth Sores HUMAN OTC DRUG LABEL 1 10237-793 LIQUID 0.02 mL ORAL OTC monograph not final 11 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 10565-001 SOLUTION 3 mL TOPICAL OTC monograph not final 14 sections
HYDROGEN PEROXIDE HUMAN OTC DRUG LABEL 1 10733-800 SOLUTION 2.65 mL TOPICAL OTC monograph not final 9 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 11344-002 SOLUTION 30 mg TOPICAL OTC monograph not final 13 sections
Hydrogen Peroxide3 Percent HUMAN OTC DRUG LABEL 1 11673-268 LIQUID 2.65 mL TOPICAL OTC MONOGRAPH NOT FINULLL 13 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 11673-871 SOLUTION 30 mg TOPICAL OTC monograph not final 11 sections
Hydrogen Peroxide HUMAN OTC DRUG LABEL 1 11822-0871 SOLUTION 0.30 kg TOPICAL OTC monograph not final 13 sections
Sore Mouth Cleanser HUMAN OTC DRUG LABEL 1 11822-1462 MOUTHWASH 1588 mg TOPICAL OTC monograph not final 12 sections
Hydrogen Peroxide3 Percent HUMAN OTC DRUG LABEL 1 11822-3155 LIQUID 2.65 mL TOPICAL OTC monograph not final 13 sections
HYDROGEN PEROXIDE HUMAN OTC DRUG LABEL 1 12745-202 LIQUID 8.57 g TOPICAL OTC monograph not final 8 sections
HYDROGEN PEROXIDE HUMAN OTC DRUG LABEL 1 12745-205 LIQUID 8.57 g TOPICAL OTC monograph not final 8 sections