homosalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
analgesic anti-inflammatory	3279	118-56-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: homosalate homomenthyl salicylate kemester	cpd not photoallergenic Molecular weight: 262.35 Formula: C16H22O3 CLOGP: 5.92 LIPINSKI: 1 HAC: 3 HDO: 1 TPSA: 46.53 ALOGS: -3.85 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

homosalate
homomenthyl salicylate
kemester

cpd not photoallergenic

Molecular weight: 262.35
Formula: C16H22O3
CLOGP: 5.92
LIPINSKI: 1
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -3.85
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	733.46	15.23	224	8124	24152	63456522
Chronic sinusitis	226.84	15.23	79	8269	12764	63467910
Paraesthesia oral	199.14	15.23	80	8268	19176	63461498
Procedural pain	187.02	15.23	79	8269	21490	63459184
Drug ineffective	114.61	15.23	347	8001	1044418	62436256
Body tinea	114.18	15.23	30	8318	1855	63478819
Vaginal flatulence	110.50	15.23	33	8315	3260	63477414
Inhibitory drug interaction	101.92	15.23	30	8318	2819	63477855
Proctitis	98.06	15.23	34	8314	5407	63475267
Radiculopathy	96.72	15.23	38	8310	8573	63472101
Infection susceptibility increased	95.65	15.23	30	8318	3491	63477183
Therapeutic product effect incomplete	95.58	15.23	99	8249	124957	63355717
Female genital tract fistula	94.29	15.23	36	8312	7523	63473151
Dyspepsia	80.03	15.23	82	8266	102114	63378560
Vaginal discharge	77.38	15.23	33	8315	9165	63471509
Glucose tolerance impaired	77.31	15.23	30	8318	6547	63474127
Poor quality sleep	77.22	15.23	42	8306	19893	63460781
Purpura	67.55	15.23	32	8316	11353	63469321
Impaired quality of life	61.74	15.23	32	8316	13751	63466923
Bone density decreased	57.18	15.23	31	8317	14581	63466093
Colitis ulcerative	54.49	15.23	37	8311	26054	63454620
Hyperlipidaemia	53.82	15.23	33	8315	19538	63461136
Impaired work ability	52.01	15.23	31	8317	17444	63463230
Oral candidiasis	51.63	15.23	34	8314	22764	63457910
Frequent bowel movements	48.92	15.23	33	8315	22989	63457685
Skin disorder	45.92	15.23	35	8313	29472	63451202
Local anaesthetic systemic toxicity	43.57	15.23	12	8336	887	63479787
Oral herpes	42.95	15.23	32	8316	26042	63454632
Removal of foreign body	42.09	15.23	7	8341	41	63480633
Pyrexia	41.66	15.23	146	8202	470332	63010342
Tracheal deviation	39.45	15.23	8	8340	154	63480520
Weight decreased	38.74	15.23	101	8247	276697	63203977
Colitis	38.05	15.23	39	8309	48489	63432185
Phrenic nerve paralysis	37.93	15.23	8	8340	188	63480486
Rectal haemorrhage	35.92	15.23	38	8310	48992	63431682
Herpes zoster	32.85	15.23	47	8301	82415	63398259
Haematochezia	31.49	15.23	37	8311	53507	63427167
Cellulitis	27.34	15.23	43	8305	81915	63398759
Infusion related reaction	26.87	15.23	82	8266	245439	63235235
Foreign body in respiratory tract	23.84	15.23	6	8342	312	63480362
Anaphylactic shock	22.25	15.23	21	8327	23612	63457062
Cataract	21.96	15.23	32	8316	57021	63423653
Constipation	21.74	15.23	72	8276	224871	63255803
Rheumatoid arthritis	20.94	15.23	4	8344	253815	63226859
Nausea	20.45	15.23	186	8162	854285	62626389
Alopecia	19.55	15.23	10	8338	337526	63143148
Purtscher retinopathy	18.97	15.23	4	8344	94	63480580
Anaemia	18.52	15.23	82	8266	293348	63187326
Jarisch-Herxheimer reaction	18.12	15.23	5	8343	372	63480302
Drug intolerance	18.09	15.23	9	8339	308652	63172022
Systemic lupus erythematosus	17.86	15.23	3	8345	208915	63271759
Chemical burn	17.53	15.23	5	8343	420	63480254
Foetal exposure during delivery	16.92	15.23	4	8344	160	63480514
Dermatophytosis	16.29	15.23	4	8344	188	63480486
Language disorder	15.72	15.23	7	8341	2153	63478521
Live birth	15.54	15.23	18	8330	25612	63455062

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	75.73	18.85	20	4513	1280	34951118
SARS-CoV-2 test negative	65.72	18.85	17	4516	1003	34951395
Proctalgia	53.36	18.85	22	4511	5701	34946697
Accident	49.09	18.85	20	4513	5027	34947371
Appendicolith	44.77	18.85	22	4511	8579	34943819
Ventricular fibrillation	42.37	18.85	30	4503	22924	34929474
Cardiogenic shock	40.59	18.85	31	4502	26587	34925811
Appendicitis	38.59	18.85	24	4509	14783	34937615
Removal of foreign body	35.76	18.85	6	4527	38	34952360
Haemorrhoids	33.93	18.85	22	4511	14553	34937845
Cardiac arrest	30.68	18.85	49	4484	96110	34856288
Body temperature increased	28.18	18.85	21	4512	17347	34935051
Ascites	25.82	18.85	31	4502	46540	34905858
Stress	23.37	18.85	24	4509	30323	34922075
Constipation	22.84	18.85	53	4480	136929	34815469
Methaemoglobinaemia	21.17	18.85	10	4523	3571	34948827
Abdominal distension	20.29	18.85	31	4502	58461	34893937
Hyponatraemia	19.63	18.85	37	4496	82654	34869744

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	209.66	14.80	74	11519	11222	79721573
Chronic sinusitis	206.74	14.80	76	11517	12950	79719845
Paraesthesia oral	186.55	14.80	80	11513	20391	79712404
Procedural pain	167.84	14.80	77	11516	23007	79709788
Body tinea	111.68	14.80	30	11563	1824	79730971
Vaginal flatulence	110.76	14.80	32	11561	2543	79730252
Female genital tract fistula	95.29	14.80	35	11558	5940	79726855
Infection susceptibility increased	91.05	14.80	30	11563	3691	79729104
Inhibitory drug interaction	89.62	14.80	31	11562	4422	79728373
Proctitis	85.58	14.80	33	11560	6399	79726396
Radiculopathy	85.38	14.80	36	11557	8788	79724007
Therapeutic product effect incomplete	85.32	14.80	104	11489	141541	79591254
Vaginal discharge	77.42	14.80	32	11561	7431	79725364
Glucose tolerance impaired	68.40	14.80	30	11563	8054	79724741
Dyspepsia	67.37	14.80	81	11512	108606	79624189
Anal inflammation	67.01	14.80	19	11574	1411	79731384
Poor quality sleep	65.63	14.80	41	11552	22681	79710114
Removal of foreign body	64.12	14.80	11	11582	71	79732724
Impaired quality of life	57.42	14.80	32	11561	14354	79718441
Bone density decreased	56.88	14.80	31	11562	13316	79719479
SARS-CoV-2 test negative	54.38	14.80	16	11577	1355	79731440
Purpura	50.83	14.80	33	11560	19494	79713301
Local anaesthetic systemic toxicity	49.37	14.80	14	11579	1040	79731755
Hyperlipidaemia	48.85	14.80	36	11557	26057	79706738
Impaired work ability	43.39	14.80	30	11563	19651	79713144
Skin disorder	42.52	14.80	37	11556	33906	79698889
Appendicolith	42.48	14.80	22	11571	8529	79724266
Oral herpes	40.74	14.80	33	11560	27421	79705374
Pyrexia	39.71	14.80	199	11394	678510	79054285
Constipation	39.52	14.80	110	11483	282940	79449855
Proctalgia	39.24	14.80	22	11571	9979	79722816
Anaphylactic shock	38.70	14.80	36	11557	35960	79696835
Oral candidiasis	38.54	14.80	33	11560	29595	79703200
Ventricular fibrillation	38.39	14.80	34	11559	31892	79700903
Colitis ulcerative	37.84	14.80	35	11558	34707	79698088
Tracheal deviation	37.77	14.80	8	11585	173	79732622
Frequent bowel movements	36.60	14.80	32	11561	29507	79703288
Accident	36.22	14.80	20	11573	8811	79723984
Chemical burn	32.92	14.80	9	11584	584	79732211
Phrenic nerve paralysis	32.72	14.80	8	11585	333	79732462
Foreign body	32.03	14.80	13	11580	2881	79729914
Foreign body in respiratory tract	31.36	14.80	8	11585	397	79732398
Appendicitis	30.86	14.80	25	11568	20769	79712026
Cardiogenic shock	30.58	14.80	34	11559	41880	79690915
Herpes zoster	30.26	14.80	51	11542	93032	79639763
Methaemoglobinaemia	29.64	14.80	15	11578	5542	79727253
Cardiac arrest	26.10	14.80	69	11524	172027	79560768
Completed suicide	25.34	14.80	3	11590	245764	79487031
Colitis	24.94	14.80	41	11552	73266	79659529
Abdominal distension	24.63	14.80	54	11539	119596	79613199
Infusion related reaction	24.15	14.80	81	11512	230156	79502639
Kounis syndrome	24.14	14.80	12	11581	4270	79728525
Haemorrhoids	23.64	14.80	25	11568	29103	79703692
Rectal haemorrhage	22.43	14.80	40	11553	76260	79656535
Haematochezia	22.08	14.80	43	11550	87602	79645193
Cataract	21.48	14.80	35	11558	62085	79670710
Weight decreased	21.28	14.80	105	11488	355093	79377702
Rheumatoid arthritis	20.40	14.80	3	11590	208467	79524328
Nausea	20.21	14.80	220	11373	956976	78775819
Ascites	18.95	14.80	37	11556	75525	79657270
Cellulitis	17.84	14.80	45	11548	109015	79623780
Purtscher retinopathy	17.56	14.80	4	11589	122	79732673
Abdominal pain	17.18	14.80	106	11487	389463	79343332
Malaise	16.10	14.80	124	11469	489745	79243050
Anaesthetic complication	16.08	14.80	8	11585	2851	79729944
Arthritis bacterial	15.71	14.80	12	11581	9154	79723641
Administration related reaction	14.99	14.80	4	11589	237	79732558
Injection site infection	14.89	14.80	7	11586	2205	79730590

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.91	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021147	VUID
N0000179485	NUI
D04450	KEGG_DRUG
4021147	VANDF
C0304631	UMLSCUI
CHEBI:91642	CHEBI
CHEMBL1377575	ChEMBL_ID
DB11064	DRUGBANK_ID
C060446	MESH_SUPPLEMENTAL_RECORD_UI
8362	PUBCHEM_CID
3183	INN_ID
V06SV4M95S	UNII
91326	RXNORM
001969	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 50 Sunscreen	HUMAN OTC DRUG LABEL	4	0023-5501	LOTION	60 mg	TOPICAL	OTC monograph not final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.12 g	TOPICAL	OTC monograph final	8 sections
Solbar Thirty SPF 30	HUMAN OTC DRUG LABEL	5	0096-0685	CREAM	0.12 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections
Solbar Zinc SPF38	HUMAN OTC DRUG LABEL	3	0096-0688	CREAM	0.10 g	TOPICAL	OTC monograph final	8 sections
Solbar Zinc SPF38	HUMAN OTC DRUG LABEL	3	0096-0688	CREAM	0.10 1	TOPICAL	OTC monograph final	8 sections
Daily Facial MoisturizerSPF 25	HUMAN OTC DRUG LABEL	4	0096-0721	CREAM	0.06 g	TOPICAL	OTC monograph final	11 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	125 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	125 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4136	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	5 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	3.50 mg	TOPICAL	OTC monograph final	5 sections
Almay Healthy Biome Makeup	HUMAN OTC DRUG LABEL	5	0311-0723	EMULSION	5 mg	TOPICAL	OTC monograph final	7 sections
Walgreens SPF 70 Sport Continuous	HUMAN OTC DRUG LABEL	4	0363-0035	SPRAY	150 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 55 Sheer Face Mist Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0053	SPRAY	1000 mg	TOPICAL	OTC monograph not final	13 sections
Walgreens SPF 50 Clear Complexion Face Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0066	LOTION	40 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Sport Faces	HUMAN OTC DRUG LABEL	5	0363-0087	LOTION	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Sport Faces	HUMAN OTC DRUG LABEL	4	0363-0090	LOTION	130 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 30 Sport	HUMAN OTC DRUG LABEL	4	0363-0093	LOTION	80 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens SPF 50 Sport Continuous Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0128	SPRAY	100 mg	TOPICAL	OTC monograph not final	12 sections
WALGREENS SPF 100 SHEER BODY SUNSCREEN MIST	HUMAN OTC DRUG LABEL	4	0363-0135	AEROSOL, SPRAY	150 mg	TOPICAL	OTC monograph not final	13 sections
Walgreens SPF 50 Hydrating	HUMAN OTC DRUG LABEL	4	0363-0136	LOTION	150 mg	TOPICAL	OTC monograph not final	11 sections
Walgreens SPF 30 Hydrating	HUMAN OTC DRUG LABEL	4	0363-0146	LOTION	80 mg	TOPICAL	OTC monograph not final	12 sections
Walgreens Daytime Facial Moisturizer with Broad Spectrum SPF 30 Sunscreen	HUMAN OTC DRUG LABEL	3	0363-0187	LOTION	150 mg	TOPICAL	OTC monograph final	12 sections
WALGREENS 100 SHEER BROAD SPECTRUM SPF 100	HUMAN OTC DRUG LABEL	4	0363-0228	LOTION	150 mg	TOPICAL	OTC monograph final	12 sections
Walgreens Advanced 50 Clear Complexion Broad Spectrum SPF 50 Sunscreen	HUMAN OTC DRUG LABEL	4	0363-0231	LOTION	100 mg	TOPICAL	OTC monograph final	12 sections
WALGREENS 100 DRY TOUCH BROAD SPECTRUM SPF 100 FACE SUNSCREEN	HUMAN OTC DRUG LABEL	5	0363-0232	LOTION	150 mg	TOPICAL	OTC monograph final	12 sections