homosalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
analgesic anti-inflammatory	3279	118-56-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: homosalate homomenthyl salicylate kemester	cpd not photoallergenic Molecular weight: 262.35 Formula: C16H22O3 CLOGP: 5.92 LIPINSKI: 1 HAC: 3 HDO: 1 TPSA: 46.53 ALOGS: -3.85 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

homosalate
homomenthyl salicylate
kemester

cpd not photoallergenic

Molecular weight: 262.35
Formula: C16H22O3
CLOGP: 5.92
LIPINSKI: 1
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -3.85
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	733.46	15.23	224	8124	24152	63456522
Chronic sinusitis	226.84	15.23	79	8269	12764	63467910
Paraesthesia oral	199.14	15.23	80	8268	19176	63461498
Procedural pain	187.02	15.23	79	8269	21490	63459184
Drug ineffective	114.61	15.23	347	8001	1044418	62436256
Body tinea	114.18	15.23	30	8318	1855	63478819
Vaginal flatulence	110.50	15.23	33	8315	3260	63477414
Inhibitory drug interaction	101.92	15.23	30	8318	2819	63477855
Proctitis	98.06	15.23	34	8314	5407	63475267
Radiculopathy	96.72	15.23	38	8310	8573	63472101

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	75.73	18.85	20	4513	1280	34951118
SARS-CoV-2 test negative	65.72	18.85	17	4516	1003	34951395
Proctalgia	53.36	18.85	22	4511	5701	34946697
Accident	49.09	18.85	20	4513	5027	34947371
Appendicolith	44.77	18.85	22	4511	8579	34943819
Ventricular fibrillation	42.37	18.85	30	4503	22924	34929474
Cardiogenic shock	40.59	18.85	31	4502	26587	34925811
Appendicitis	38.59	18.85	24	4509	14783	34937615
Removal of foreign body	35.76	18.85	6	4527	38	34952360
Haemorrhoids	33.93	18.85	22	4511	14553	34937845

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	209.66	14.80	74	11519	11222	79721573
Chronic sinusitis	206.74	14.80	76	11517	12950	79719845
Paraesthesia oral	186.55	14.80	80	11513	20391	79712404
Procedural pain	167.84	14.80	77	11516	23007	79709788
Body tinea	111.68	14.80	30	11563	1824	79730971
Vaginal flatulence	110.76	14.80	32	11561	2543	79730252
Female genital tract fistula	95.29	14.80	35	11558	5940	79726855
Infection susceptibility increased	91.05	14.80	30	11563	3691	79729104
Inhibitory drug interaction	89.62	14.80	31	11562	4422	79728373
Proctitis	85.58	14.80	33	11560	6399	79726396

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
MeSH PA	D003358	Cosmetics
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D020011	Protective Agents
MeSH PA	D011837	Radiation-Protective Agents
MeSH PA	D013473	Sunscreening Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.91	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
001969	NDDF
3183	INN_ID
4021147	VUID
4021147	VANDF
8362	PUBCHEM_CID
91326	RXNORM
C0304631	UMLSCUI
C060446	MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:91642	CHEBI
CHEMBL1377575	ChEMBL_ID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Almay Anti Aging Lip Care SPF 20	HUMAN OTC DRUG LABEL	5	0311-0709	LIPSTICK	5 mg	TOPICAL	OTC monograph final	8 sections
Almay Best Blend Forever Makeup	HUMAN OTC DRUG LABEL	4	0311-0719	LOTION	3.50 mg	TOPICAL	OTC monograph final	5 sections
Almay Healthy Biome Makeup	HUMAN OTC DRUG LABEL	5	0311-0723	EMULSION	5 mg	TOPICAL	OTC monograph final	7 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	HUMAN OTC DRUG LABEL	4	0299-4113	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	125 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Radiance Whipped Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4118	LOTION	125 mg	TOPICAL	OTC monograph final	12 sections
Cetaphil Healthy Renew Day Cream Broad Spectrum SPF 30	HUMAN OTC DRUG LABEL	4	0299-4136	LOTION	95 mg	TOPICAL	OTC monograph final	12 sections
Daily Facial MoisturizerSPF 25	HUMAN OTC DRUG LABEL	4	0096-0721	CREAM	0.06 g	TOPICAL	OTC monograph final	11 sections
Solbar Avo SPF35	HUMAN OTC DRUG LABEL	4	0096-0687	CREAM	0.08 g	TOPICAL	OTC monograph final	8 sections

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