fumagillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics produced by Aspergillus strains | 3253 | 23110-15-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
empirical formula C25-27H34-37O7, a monoester of decatetraenedioic acid (HOOC-(C=CH)4-COOH and fumagillin (C16-17H25-26O3); FR 65814 lacks the fat
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P01AX10 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES Other agents against amoebiasis and other protozoal diseases |
| MeSH PA | D020533 | Angiogenesis Inhibitors |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D006131 | Growth Inhibitors |
| MeSH PA | D006133 | Growth Substances |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:48422 | angiogenesis antagonist |
| CHEBI has role | CHEBI:73361 | methionine aminopeptidase 2 inhibitors |
| CHEBI has role | CHEBI:76946 | fungal metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.13 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 2 | Enzyme | IC50 | 9.20 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0060819 | UMLSCUI |
| CHEBI:48635 | CHEBI |
| FUG | PDB_CHEM_ID |
| CHEMBL32838 | ChEMBL_ID |
| DB02640 | DRUGBANK_ID |
| C026211 | MESH_SUPPLEMENTAL_RECORD_UI |
| 225 | INN_ID |
| 7OW73204U1 | UNII |
| 6917655 | PUBCHEM_CID |
| 1926480 | RXNORM |
| 29765001 | SNOMEDCT_US |
Pharmaceutical products:
None