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benzocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	323	94-09-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: benzocaine norcaine 4-Carbethoxyaniline benzocaine hydrobromide benzocaine hydrochloride benzocaine HCl benzocaine methanesulfonate ethyl aminobenzoate parathesin americaine benzocaine formate	A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS. Molecular weight: 165.19 Formula: C9H11NO2 CLOGP: 1.92 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 52.32 ALOGS: -1.76 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

benzocaine
norcaine
4-Carbethoxyaniline
benzocaine hydrobromide
benzocaine hydrochloride
benzocaine HCl
benzocaine methanesulfonate
ethyl aminobenzoate
parathesin
americaine
benzocaine formate

A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.

Molecular weight: 165.19
Formula: C9H11NO2
CLOGP: 1.92
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 52.32
ALOGS: -1.76
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Irritable bowel syndrome	250.74	23.50	182	14315	82230	63392295
Gastrointestinal toxicity	219.36	23.50	78	14419	7663	63466862
Methaemoglobinaemia	217.65	23.50	59	14438	2344	63472181
Helicobacter infection	210.17	23.50	172	14325	92613	63381912
Pulmonary toxicity	204.15	23.50	78	14419	9377	63465148
Arthropathy	200.85	23.50	257	14240	234535	63239990
Ill-defined disorder	192.39	23.50	155	14342	81600	63392925
Muscle injury	184.43	23.50	138	14359	65207	63409318
Folliculitis	181.94	23.50	141	14356	70176	63404349
Blister	176.92	23.50	181	14316	129633	63344892

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	279.72	21.30	65	3140	3516	34950210
Drug abuse	246.40	21.30	137	3068	98959	34854767
Intentional product misuse	137.81	21.30	72	3133	45539	34908187
Toxicity to various agents	129.06	21.30	122	3083	200240	34753486
Serotonin syndrome	82.41	21.30	39	3166	19894	34933832
Completed suicide	79.06	21.30	68	3137	98100	34855626
Respiratory arrest	78.14	21.30	42	3163	28001	34925725
Hangover	41.23	21.30	11	3194	1040	34952686
Cardiac arrest	37.38	21.30	45	3160	96114	34857612
Intentional overdose	34.53	21.30	30	3175	43644	34910082

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	447.42	19.26	117	13539	5440	79725292
Drug abuse	215.28	19.26	196	13460	162495	79568237
Irritable bowel syndrome	184.07	19.26	121	13535	62120	79668612
Helicobacter infection	167	19.26	119	13537	69585	79661147
Arthropathy	142.08	19.26	163	13493	176948	79553784
Pericarditis	130.73	19.26	122	13534	104114	79626618
Sleep disorder due to general medical condition, insomnia type	127.07	19.26	84	13572	43472	79687260
Blister	120.28	19.26	124	13532	119352	79611380
Ill-defined disorder	116.83	19.26	94	13562	65781	79664951
Discomfort	113.35	19.26	123	13533	125494	79605238

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C05AD03	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics
ATC	D04AB04	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use
ATC	N01BA05	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Esters of aminobenzoic acid
ATC	R02AD01	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Anesthetics, local
CHEBI has role	CHEBI:48425	topical anesthetic
CHEBI has role	CHEBI:50904	alergeno
CHEBI has role	CHEBI:59683	antipruritic drugs
CHEBI has role	CHEBI:139492	sensitizers
FDA CS	M0000728	Allergens
FDA EPC	N0000185508	Standardized Chemical Allergen

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Tinea pedis	indication	6020002	DOID:12403
Cough	indication	49727002
Tinea corporis	indication	84849002
Sore throat symptom	indication	267102003
Skin irritation	indication	367466007
Local anesthesia	indication	386761002
Itching of skin	indication	418363000
Suppression of the Gag Reflex	indication
Tinea Infections	indication
Minor Skin Wound Pain	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.5	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium channel protein type 1 subunit alpha	Ion channel	P35498	SCN1A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 2 subunit alpha	Ion channel	Q99250	SCN2A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 3 subunit alpha	Ion channel	Q9NY46	SCN3A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 4 subunit alpha	Ion channel	P35499	SCN4A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 8 subunit alpha	Ion channel	Q9UQD0	SCN8A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 9 subunit alpha	Ion channel	Q15858	SCN9A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 11 subunit alpha	Ion channel	Q9UI33	SCNBA_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 10 subunit alpha	Ion channel	Q9Y5Y9	SCNAA_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 7 subunit alpha	Ion channel	Q01118	SCN7A_HUMAN	BLOCKER			SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN	BLOCKER	ED50	3.50	SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

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External reference:

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ID	Source
001366	NDDF
1049105	RXNORM
199	MMSL
23239-88-5	SECONDARY_CAS_RN
2337	PUBCHEM_CID
359	MMSL
387357002	SNOMEDCT_US
3953	INN_ID
4018117	VUID
4018117	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
good sense vagicaineanti itch	HUMAN OTC DRUG LABEL	2	0113-0142	CREAM	20 g	TOPICAL	OTC monograph not final	13 sections
HurriCaine	HUMAN OTC DRUG LABEL	1	0283-0610	SPRAY	200 mg	DENTAL	OTC monograph not final	12 sections
HurriCaine	HUMAN OTC DRUG LABEL	1	0283-0610	SPRAY	200 mg	DENTAL	OTC monograph not final	12 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0914	SPRAY	200 mg	ORAL	OTC monograph not final	11 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0914	SPRAY	200 mg	ORAL	OTC monograph not final	11 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0220	GEL	200 mg	ORAL	OTC monograph not final	12 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0220	GEL	200 mg	ORAL	OTC monograph not final	12 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0520	GEL	200 mg	ORAL	OTC monograph not final	12 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0520	GEL	200 mg	ORAL	OTC monograph not final	12 sections
HurriCaine Topical Anesthetic	HUMAN OTC DRUG LABEL	1	0283-0871	GEL	200 mg	ORAL	OTC monograph not final	12 sections

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