fumaric acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3229 110-17-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fumaric acid
  • 2-(E)-butenedioic acid
  • allomaleic acid
see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters
  • Molecular weight: 116.07
  • Formula: C4H4O4
  • CLOGP: -0.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -0.68
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D05AX01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Other antipsoriatics for topical use
CHEBI has role CHEBI:64049 food acidity regulator

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 4.93 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Egl nine homolog 1 Enzyme IC50 4.72 CHEMBL

External reference:

IDSource
4020189 VUID
N0000179140 NUI
C0060825 UMLSCUI
D02308 KEGG_DRUG
4020189 VANDF
NOCODE MMSL
25389 RXNORM
006838 NDDF
88XHZ13131 UNII
444972 PUBCHEM_CID
CHEBI:18012 CHEBI
CHEMBL503160 ChEMBL_ID
FUM PDB_CHEM_ID
DB01677 DRUGBANK_ID
C032005 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Viatrexx-Adipose HUMAN PRESCRIPTION DRUG LABEL 10 73069-024 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Cellulite HUMAN PRESCRIPTION DRUG LABEL 10 73069-081 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Facial HUMAN PRESCRIPTION DRUG LABEL 11 73069-164 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Liver HUMAN PRESCRIPTION DRUG LABEL 9 73069-300 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections
Viatrexx-Pigmentation HUMAN PRESCRIPTION DRUG LABEL 9 73069-410 INJECTION 31 [kp_C] INTRAVENOUS unapproved drug other 11 sections