fumaric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3229 110-17-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fumaric acid
  • 2-(E)-butenedioic acid
  • allomaleic acid
see also record for ferrous fumarate; use FUMARATES for general fumaric acid esters
  • Molecular weight: 116.07
  • Formula: C4H4O4
  • CLOGP: -0.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -0.68
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D05AX01 DERMATOLOGICALS
ANTIPSORIATICS
ANTIPSORIATICS FOR TOPICAL USE
Other antipsoriatics for topical use
CHEBI has role CHEBI:64049 pH control agents
CHEBI has role CHEBI:78675 fundamental metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Psoriasis indication 9014002 DOID:8893




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.46 acidic
pKa2 4.93 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Egl nine homolog 1 Enzyme IC50 4.72 CHEMBL

External reference:

IDSource
4020189 VUID
N0000179140 NUI
D02308 KEGG_DRUG
4020189 VANDF
C0060825 UMLSCUI
CHEBI:18012 CHEBI
FUM PDB_CHEM_ID
CHEMBL503160 ChEMBL_ID
DB01677 DRUGBANK_ID
C032005 MESH_SUPPLEMENTAL_RECORD_UI
88XHZ13131 UNII
444972 PUBCHEM_CID
25389 RXNORM
NOCODE MMSL
006838 NDDF

Pharmaceutical products:

None