femoxetine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 3220 59859-58-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • femoxetine
serotonin uptake inhibitor; RN given refers to (3R-trans)-isomer
  • Molecular weight: 311.43
  • Formula: C20H25NO2
  • CLOGP: 4.07
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 21.70
  • ALOGS: -4.41
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 8 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR Ki 6.66 PDSP
Muscarinic acetylcholine receptor M2 GPCR Ki 6.82 PDSP
Sodium-dependent serotonin transporter Transporter Ki 7.96 PDSP
Muscarinic acetylcholine receptor M1 GPCR Ki 7.04 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 6.40 PDSP
Muscarinic acetylcholine receptor M4 GPCR Ki 6.33 PDSP
D(2) dopamine receptor GPCR Ki 6.23 PDSP
Sodium-dependent noradrenaline transporter Transporter Ki 6.12 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.69 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 5.64 PDSP
Histamine H1 receptor GPCR Ki 5.38 PDSP
Sodium-dependent dopamine transporter Transporter Ki 8.04 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 6.92 CHEMBL

External reference:

IDSource
8Y719ZLX8C UNII
4032 INN_ID
CHEMBL94739 ChEMBL_ID
C010655 MESH_SUPPLEMENTAL_RECORD_UI
3012003 PUBCHEM_CID

Pharmaceutical products:

None