exisulind 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antineoplastics, sulindac metabolites | 3219 | 59973-80-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
inhibits K-ras-dependent cyclooxygenase-2; sulfated analog of indomethacin;; CP248 is an antineoplastic agent that fosters microtubule depolymerization
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D016588 | Anticarcinogenic Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:50629 | COX-2 inhibitor |
| CHEBI has role | CHEBI:64964 | 5delta-lipoxygenase inhibitor |
| CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.33 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | GPCR | Ki | 5.22 | DRUG MATRIX | |||||
| Mitogen-activated protein kinase 1 | Kinase | IC50 | 4.86 | DRUG MATRIX | |||||
| Aldose reductase | Enzyme | IC50 | 6.57 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| C0075616 | UMLSCUI |
| CHEBI:64212 | CHEBI |
| SLO | PDB_CHEM_ID |
| CHEMBL488025 | ChEMBL_ID |
| DB06246 | DRUGBANK_ID |
| 5472495 | PUBCHEM_CID |
| C025463 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7744 | INN_ID |
| K619IIG2R9 | UNII |
Pharmaceutical products:
None