evans blue 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3217 | 314-13-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An azo dye used in blood volume and cardiac output measurement by the dye dilution method. It is very soluble, strongly bound to plasma albumin, and disappears very slowly.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PARKE DAVIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D004396 | Coloring Agents |
| CHEBI has role | CHEBI:38633 | sodium channel blockers |
| CHEBI has role | CHEBI:50905 | teratogeno |
| CHEBI has role | CHEBI:51217 | fluorochromes |
| CHEBI has role | CHEBI:77178 | biological stain |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.35 | acidic |
| pKa2 | 8.95 | acidic |
| pKa3 | 1.19 | Basic |
| pKa4 | 0.58 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | Enzyme | IC50 | 5.89 | CHEMBL | |||||
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enzyme | Ki | 6.08 | CHEMBL | |||||
| Tyrosine-protein phosphatase 1 | Enzyme | IC50 | 5.92 | CHEMBL | |||||
| Vesicular glutamate transporter 3 | Transporter | Ki | 7.40 | CHEMBL | |||||
| Luciferin 4-monooxygenase | Enzyme | IC50 | 5.77 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019071 | VUID |
| N0000147338 | NUI |
| 4019071 | VANDF |
| C0015205 | UMLSCUI |
| CHEBI:82467 | CHEBI |
| CHEMBL1200712 | ChEMBL_ID |
| CHEMBL1015 | ChEMBL_ID |
| D005070 | MESH_DESCRIPTOR_UI |
| DB09361 | DRUGBANK_ID |
| 45PG892GO1 | UNII |
| 9409 | PUBCHEM_CID |
| 4191 | RXNORM |
| 002040 | NDDF |
| 002625 | NDDF |
Pharmaceutical products:
None