nordefrin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3203	74812-63-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cobefrin
nordefrin
nordefrin hydrochloride
nordefrin HCl

A norepinephrine derivative used as a vasoconstrictor agent.

Molecular weight: 183.21
Formula: C9H13NO3
CLOGP: -0.68
LIPINSKI: 0
HAC: 4
HDO: 4
TPSA: 86.71
ALOGS: -1.10
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014662	Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.45	acidic
pKa2	12.29	acidic
pKa3	12.9	acidic
pKa4	8.73	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		Ki	8.11		CHEMBL

External reference:

ID	Source
61-96-1	SECONDARY_CAS_RN
CHEBI:81386	CHEBI
CHEMBL677	ChEMBL_ID
CHEMBL764	ChEMBL_ID
CHEMBL1612659	ChEMBL_ID
R81X549E70	UNII
387230002	SNOMEDCT_US
C0025805	UMLSCUI
D008771	MESH_DESCRIPTOR_UI
164739	PUBCHEM_CID

Pharmaceutical products:

None