estriol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 3187 50-27-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estriol
  • destriol
  • estratriol
  • ovestrion
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
  • Molecular weight: 288.39
  • Formula: C18H24O3
  • CLOGP: 3.20
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: -3.38
  • ROTB: 0

Drug dosage:

DoseUnitRoute
2 mg O
2 mg P
0.20 mg V

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lip blister 31.58 19.74 9 2251 2066 46681736
Hyponatraemia 27.57 19.74 29 2231 101303 46582499
Chronotropic incompetence 23.43 19.74 4 2256 83 46683719
Local reaction 22.13 19.74 5 2255 452 46683350
Therapeutic drug monitoring analysis incorrectly performed 20.83 19.74 4 2256 163 46683639

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC G03CA04 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Natural and semisynthetic estrogens, plain
ATC G03CC06 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
ESTROGENS
Estrogens, combinations with other drugs
CHEBI has role CHEBI:50114 oestrogene
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST Ki 8.67 IUPHAR IUPHAR
Glucocorticoid receptor Nuclear hormone receptor Ki 4.75 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 6.63 CHEMBL
Estrogen receptor beta Nuclear hormone receptor AGONIST Ki 8.40 IUPHAR
Sodium-dependent serotonin transporter Transporter Ki 5.26 DRUG MATRIX
Corticosteroid-binding globulin Secreted Ki 5 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.06 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme Kd 4 CHEMBL

External reference:

IDSource
N0000167513 NUI
D00185 KEGG_DRUG
C0014927 UMLSCUI
CHEBI:27974 CHEBI
ESL PDB_CHEM_ID
CHEMBL193482 ChEMBL_ID
DB04573 DRUGBANK_ID
D004964 MESH_DESCRIPTOR_UI
5756 PUBCHEM_CID
2821 IUPHAR_LIGAND_ID
FB33469R8E UNII
4094 RXNORM
132550 MMSL
18220 MMSL
NOCODE MMSL
d05027 MMSL
001285 NDDF
354050008 SNOMEDCT_US
73723004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BiEST 2.5 Estrogen Cream HUMAN OTC DRUG LABEL 2 82018-0007 CREAM 2 mg TRANSDERMAL unapproved drug other 10 sections
BiEST 2.5 Estrogen Cream (Lavender scented) HUMAN OTC DRUG LABEL 2 82018-0008 CREAM 2 mg TRANSDERMAL unapproved drug other 10 sections
BiEST 5.0 Estrogen Cream HUMAN OTC DRUG LABEL 2 82018-0009 CREAM 4 mg TRANSDERMAL unapproved drug other 10 sections
Estriol 5.0 Cream HUMAN OTC DRUG LABEL 1 82018-0010 CREAM 5 mg TRANSDERMAL unapproved drug other 10 sections