Stem definition | Drug id | CAS RN |
---|---|---|
antiarrhythmics | 318 | 3562-84-3 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Hosey CM, Chan R, Benet LZ |
None
None
None
Source | Code | Description |
---|---|---|
ATC | M04AB03 | MUSCULO-SKELETAL SYSTEM ANTIGOUT PREPARATIONS ANTIGOUT PREPARATIONS Preparations increasing uric acid excretion |
CHEBI has role | CHEBI:35841 | uricosuric agent |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D006074 | Gout Suppressants |
MeSH PA | D014528 | Uricosuric Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hyperuricemia | indication | 35885006 | DOID:1920 |
Gout | indication | 90560007 | DOID:13189 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.91 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Solute carrier family 22 member 12 | Transporter | INHIBITOR | IC50 | 7.59 | CHEMBL | SCIENTIFIC LITERATURE | |||
Adenosine receptor A3 | GPCR | Ki | 5.53 | DRUG MATRIX | |||||
Cytochrome P450 2C9 | Enzyme | IC50 | 7.80 | DRUG MATRIX | |||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Enzyme | IC50 | 5.98 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 14 | Kinase | IC50 | 5.91 | DRUG MATRIX | |||||
Mitogen-activated protein kinase 1 | Kinase | IC50 | 5.71 | DRUG MATRIX | |||||
Multidrug resistance-associated protein 1 | Transporter | Ki | 6.72 | CHEMBL | |||||
Aldo-keto reductase family 1 member C1 | Enzyme | IC50 | 7.32 | CHEMBL | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.94 | DRUG MATRIX | |||||
Envelope glycoprotein gp160 | Unclassified | IC50 | 4.89 | CHEMBL | |||||
M1-family alanyl aminopeptidase | Unclassified | IC50 | 4.20 | CHEMBL |
ID | Source |
---|---|
4POG0RL69O | UNII |
N0000166974 | NUI |
D01056 | KEGG_DRUG |
C0005035 | UMLSCUI |
CHEBI:3023 | CHEBI |
R75 | PDB_CHEM_ID |
CHEMBL388590 | ChEMBL_ID |
DB12319 | DRUGBANK_ID |
D001553 | MESH_DESCRIPTOR_UI |
2333 | PUBCHEM_CID |
1427 | INN_ID |
1385 | RXNORM |
005311 | NDDF |
698025001 | SNOMEDCT_US |
703372005 | SNOMEDCT_US |
None