enoxolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 3178 471-53-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • enoxolone
  • uralenic acid
  • arthrodont
  • biosone
  • glycyrrhetic acid
  • glycyrrhetin
  • glycyrrhetinic acid
  • subglycyrrhelinic acid
An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
  • Molecular weight: 470.69
  • Formula: C30H46O4
  • CLOGP: 6.48
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 2
  • TPSA: 74.60
  • ALOGS: -5.44
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D03AX10 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:50846 Biomodulator
CHEBI has role CHEBI:76924 plant metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Arachidonate 5-lipoxygenase Enzyme IC50 4.61 CHEMBL
Tyrosine-protein phosphatase non-receptor type 1 Enzyme IC50 4.34 CHEMBL
Liver carboxylesterase 1 Enzyme IC50 4.68 CHEMBL
Protein kinase C eta type Kinase Kd 6.60 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme IC50 8.91 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 8.07 CHEMBL
Cocaine esterase Enzyme IC50 4.16 CHEMBL
Aldo-keto reductase family 1 member B10 Enzyme IC50 5.31 CHEMBL
Tyrosine-protein phosphatase non-receptor type 11 Enzyme IC50 5.02 CHEMBL
Protein-tyrosine phosphatase 1C Enzyme IC50 4.18 CHEMBL
High mobility group protein B1 Nuclear other Kd 4.06 CHEMBL
Glycogen phosphorylase, muscle form Enzyme IC50 4.18 CHEMBL
Beta-glucuronidase Enzyme IC50 4.01 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 8.70 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme IC50 7.05 CHEMBL
Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme IC50 6.44 CHEMBL
Lactoylglutathione lyase Enzyme Ki 6.54 CHEMBL
Beta-glucuronidase Enzyme IC50 4.92 CHEMBL

External reference:

IDSource
N0000166340 NUI
D00156 KEGG_DRUG
C0017986 UMLSCUI
CHEBI:30853 CHEBI
CBW PDB_CHEM_ID
CHEMBL230006 ChEMBL_ID
CHEMBL441687 ChEMBL_ID
DB13089 DRUGBANK_ID
11264 IUPHAR_LIGAND_ID
1794 INN_ID
P540XA09DR UNII
10114 PUBCHEM_CID
1311506 RXNORM
005620 NDDF
414356009 SNOMEDCT_US
414357000 SNOMEDCT_US
D006034 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None