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eicosapentaenoic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3174	10417-94-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: eicosapentaenoic acid icosapent icosapentaenoic acid timnodonic acid	Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families. Molecular weight: 302.46 Formula: C20H30O2 CLOGP: 6.91 LIPINSKI: 1 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -6.02 ROTB: 13 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

eicosapentaenoic acid
icosapent
icosapentaenoic acid
timnodonic acid

Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.

Molecular weight: 302.46
Formula: C20H30O2
CLOGP: 6.91
LIPINSKI: 1
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -6.02
ROTB: 13

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatic disorder	102.78	35.92	23	2001	3049	63483949
Blood immunoglobulin M increased	87.58	35.92	17	2007	1126	63485872
Blood immunoglobulin A decreased	85.18	35.92	17	2007	1300	63485698
Colitis microscopic	77.41	35.92	23	2001	9316	63477682
Blood immunoglobulin G increased	74.82	35.92	17	2007	2410	63484588
Hernia	70.67	35.92	23	2001	12551	63474447
Cataract operation	70.21	35.92	19	2005	5503	63481495
Multiple allergies	68.57	35.92	23	2001	13779	63473219
Skin reaction	66.92	35.92	23	2001	14826	63472172
Drug-induced liver injury	66.06	35.92	30	1994	40192	63446806

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatic disorder	97.66	27.66	23	3065	3135	79738165
Blood immunoglobulin M increased	81.23	27.66	17	3071	1349	79739951
Blood immunoglobulin A decreased	80.19	27.66	17	3071	1436	79739864
Colitis microscopic	73.77	27.66	24	3064	10744	79730556
Cataract operation	72.29	27.66	20	3068	5165	79736135
Multiple allergies	70.39	27.66	23	3065	10437	79730863
Blood immunoglobulin G increased	67.99	27.66	17	3071	2972	79738328
Skin reaction	60.73	27.66	23	3065	16045	79725255
Glaucoma	59.55	27.66	24	3064	19737	79721563
Hernia	59.39	27.66	23	3065	17036	79724264

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35821	anticholesteremic drugs
CHEBI has role	CHEBI:50733	Dietary Supplement
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76946	fungal metabolites
CHEBI has role	CHEBI:83038	Daphnia galeata metabolites
CHEBI has role	CHEBI:35476	neuroleptics
CHEBI has role	CHEBI:50266	Prodrugs

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Pregnancy, function	indication	289908002
Breastfeeding (mother)	indication	413712001
Hypertriglyceridemia	off-label use	302870006
Myocardial Reinfarction Prevention	off-label use
Prevention of Fetal Neural Tube Defects during Pregnancy	off-label use
Arteriosclerotic Vascular Disease Prevention	off-label use
Peptic ulcer	contraindication	13200003	DOID:750
Bipolar disorder	contraindication	13746004	DOID:3312
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.79	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Aromatase	Enzyme	P11511	CP19A_HUMAN	IC50	4.27	CHEMBL
Peroxisome proliferator-activated receptor alpha	Nuclear hormone receptor	Q07869	PPARA_HUMAN	IC50	5.96	CHEMBL
Peroxisome proliferator-activated receptor gamma	Nuclear hormone receptor	P37231	PPARG_HUMAN	Kd	5.70	CHEMBL
Retinoic acid receptor RXR-alpha	Nuclear hormone receptor	P19793	RXRA_HUMAN	Ki	5.12	CHEMBL
Peroxisome proliferator-activated receptor delta	Nuclear hormone receptor	Q03181	PPARD_HUMAN	IC50	5.40	CHEMBL
Tissue factor	Membrane receptor	P13726	TF_HUMAN	IC50	4.11	CHEMBL
Oxoeicosanoid receptor 1	GPCR	Q8TDS5	OXER1_HUMAN	IC50	5.70	CHEMBL
Prostaglandin G/H synthase 2	Enzyme		PGH2_SHEEP	IC50	5.15	CHEMBL
Prostaglandin G/H synthase 1	Enzyme		PGH1_BOVIN	IC50	4.89	CHEMBL

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External reference:

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ID	Source
002052	NDDF
226367006	SNOMEDCT_US
4020139	VUID
4020139	VANDF
446284	PUBCHEM_CID
6328	INN_ID
7441	IUPHAR_LIGAND_ID
763707009	SNOMEDCT_US
90	RXNORM
AAN7QOV9EA	UNII

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Animi-3	HUMAN PRESCRIPTION DRUG LABEL	8	66213-543	CAPSULE	35 mg	ORAL	unapproved drug other	14 sections
Animi-3 with Vitamin D	HUMAN PRESCRIPTION DRUG LABEL	8	66213-542	CAPSULE	35 mg	ORAL	unapproved drug other	14 sections
PNV-Omega	HUMAN PRESCRIPTION DRUG LABEL	13	42192-332	CAPSULE, GELATIN COATED	40 mg	ORAL	unapproved drug other	12 sections
Prenate Essential	HUMAN PRESCRIPTION DRUG LABEL	14	75854-313	CAPSULE, GELATIN COATED	40 mg	ORAL	unapproved drug other	13 sections
TRICARE PRENATAL DHA ONE	HUMAN PRESCRIPTION DRUG LABEL	17	67112-401	CAPSULE, GELATIN COATED	45 mg	ORAL	unapproved drug other	12 sections
TriStart DHA	HUMAN PRESCRIPTION DRUG LABEL	15	15370-250	CAPSULE, LIQUID FILLED	15 mg	ORAL	UNAPPROVED DRUG OTHER	12 sections

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