Stem definition | Drug id | CAS RN |
---|---|---|
3157 | 520-27-4 |
None
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tubulointerstitial nephritis and uveitis syndrome | 67.48 | 40.79 | 10 | 1029 | 225 | 56290803 |
Erysipelas | 65.71 | 40.79 | 17 | 1022 | 7196 | 56283832 |
Myoglobin blood increased | 43.98 | 40.79 | 9 | 1030 | 1355 | 56289673 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood lactic acid | 94.54 | 49.06 | 14 | 544 | 332 | 31696454 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood lactic acid | 86.62 | 29.88 | 14 | 1616 | 449 | 70926365 |
Tubulointerstitial nephritis and uveitis syndrome | 62.03 | 29.88 | 10 | 1620 | 315 | 70926499 |
Erysipelas | 56.61 | 29.88 | 17 | 1613 | 9907 | 70916907 |
Ventricular tachycardia | 38.16 | 29.88 | 18 | 1612 | 36405 | 70890409 |
Myoglobin blood increased | 34.80 | 29.88 | 9 | 1621 | 3038 | 70923776 |
Hypercapnia | 33.79 | 29.88 | 11 | 1619 | 8318 | 70918496 |
Lentigo maligna | 31.87 | 29.88 | 6 | 1624 | 470 | 70926344 |
None
Source | Code | Description |
---|---|---|
ATC | C05CA03 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
ATC | C05CA53 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
CHEBI has role | CHEBI:22586 | antioxidants |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.73 | acidic |
pKa2 | 10.43 | acidic |
pKa3 | 12.32 | acidic |
pKa4 | 13.05 | acidic |
pKa5 | 13.7 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Inhibitor of nuclear factor kappa-B kinase subunit beta | Kinase | IC50 | 5.41 | CHEMBL | |||||
Lysine-specific histone demethylase 1A | Enzyme | IC50 | 4.99 | CHEMBL |
ID | Source |
---|---|
N0000167025 | NUI |
D07858 | KEGG_DRUG |
4036523 | VANDF |
C0012498 | UMLSCUI |
CHEBI:4631 | CHEBI |
CHEMBL231884 | ChEMBL_ID |
D004145 | MESH_DESCRIPTOR_UI |
DB08995 | DRUGBANK_ID |
4370 | INN_ID |
7QM776WJ5N | UNII |
5281613 | PUBCHEM_CID |
3489 | RXNORM |
005803 | NDDF |
126142004 | SNOMEDCT_US |
8143001 | SNOMEDCT_US |
None