Stem definition | Drug id | CAS RN |
---|---|---|
3157 | 520-27-4 |
None
None
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Tubulointerstitial nephritis and uveitis syndrome | 70.51 | 38.55 | 10 | 912 | 166 | 50604036 |
Erysipelas | 57.62 | 38.55 | 15 | 907 | 6593 | 50597609 |
Myoglobin blood increased | 44.58 | 38.55 | 9 | 913 | 1284 | 50602918 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood lactic acid | 94.28 | 44.94 | 14 | 517 | 332 | 29573664 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Blood lactic acid | 86.17 | 30.43 | 14 | 1517 | 449 | 64496752 |
Tubulointerstitial nephritis and uveitis syndrome | 63.06 | 30.43 | 10 | 1521 | 274 | 64496927 |
Erysipelas | 53.21 | 30.43 | 16 | 1515 | 9065 | 64488136 |
Myoglobin blood increased | 35.44 | 30.43 | 9 | 1522 | 2738 | 64494463 |
Lentigo maligna | 31.83 | 30.43 | 6 | 1525 | 458 | 64496743 |
None
Source | Code | Description |
---|---|---|
ATC | C05CA03 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
ATC | C05CA53 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES CAPILLARY STABILIZING AGENTS Bioflavonoids |
CHEBI has role | CHEBI:22586 | antioxidants |
CHEBI has role | CHEBI:67079 | anti-inflammatory agents |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.73 | acidic |
pKa2 | 10.43 | acidic |
pKa3 | 12.32 | acidic |
pKa4 | 13.05 | acidic |
pKa5 | 13.7 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Inhibitor of nuclear factor kappa-B kinase subunit beta | Kinase | IC50 | 5.41 | CHEMBL | |||||
Lysine-specific histone demethylase 1A | Enzyme | IC50 | 4.99 | CHEMBL |
ID | Source |
---|---|
N0000167025 | NUI |
D07858 | KEGG_DRUG |
4036523 | VANDF |
C0012498 | UMLSCUI |
CHEBI:4631 | CHEBI |
CHEMBL231884 | ChEMBL_ID |
D004145 | MESH_DESCRIPTOR_UI |
DB08995 | DRUGBANK_ID |
4370 | INN_ID |
7QM776WJ5N | UNII |
5281613 | PUBCHEM_CID |
3489 | RXNORM |
005803 | NDDF |
126142004 | SNOMEDCT_US |
8143001 | SNOMEDCT_US |
None