DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
diosmin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
3157
520-27-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
diosmin
barosmin
diosmil
diosmine
flebosten
flebosmil
A bioflavonoid that strengthens vascular walls.
Molecular weight: 608.55
Formula: C28H32O15
CLOGP: 0.23
LIPINSKI: 3
HAC: 15
HDO: 8
TPSA: 234.29
ALOGS: -2.60
ROTB: 7
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
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entries
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Tubulointerstitial nephritis and uveitis syndrome
67.86
34.67
10
1072
235
63487705
Erysipelas
65.51
34.67
17
1065
7888
63480052
Myoglobin blood increased
44.42
34.67
9
1073
1396
63486544
Delirium
37.71
34.67
18
1064
50523
63437417
Hypercapnia
36.96
34.67
10
1072
5421
63482519
Showing 1 to 5 of 5 entries
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1
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FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Blood lactic acid
95.49
48.84
14
561
332
34956024
Showing 1 to 1 of 1 entries
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1
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FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Blood lactic acid
87.64
30.61
14
1690
449
79742235
Tubulointerstitial nephritis and uveitis syndrome
62.46
30.61
10
1694
325
79742359
Erysipelas
56.33
30.61
17
1687
10833
79731851
Ventricular tachycardia
36.98
30.61
18
1686
41917
79700767
Myoglobin blood increased
35.15
30.61
9
1695
3142
79739542
Hypercapnia
33.82
30.61
11
1693
8924
79733760
Lentigo maligna
31.31
30.61
6
1698
556
79742128
Showing 1 to 7 of 7 entries
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C05CA03
CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
CAPILLARY STABILIZING AGENTS
Bioflavonoids
ATC
C05CA53
CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
CAPILLARY STABILIZING AGENTS
Bioflavonoids
CHEBI has role
CHEBI:22586
antioxidants
CHEBI has role
CHEBI:67079
anti-inflammatory agents
Showing 1 to 4 of 4 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
6.73
acidic
pKa2
10.43
acidic
pKa3
12.32
acidic
pKa4
13.05
acidic
pKa5
13.7
acidic
Showing 1 to 5 of 5 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Inhibitor of nuclear factor kappa-B kinase subunit beta
Kinase
O14920
IKKB_HUMAN
IC50
5.41
CHEMBL
Lysine-specific histone demethylase 1A
Enzyme
O60341
KDM1A_HUMAN
IC50
4.99
CHEMBL
Showing 1 to 2 of 2 entries
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External reference:
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entries
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ID
Source
005803
NDDF
126142004
SNOMEDCT_US
3489
RXNORM
4036523
VANDF
4370
INN_ID
5281613
PUBCHEM_CID
7QM776WJ5N
UNII
8143001
SNOMEDCT_US
C0012498
UMLSCUI
CHEBI:4631
CHEBI
Showing 1 to 10 of 15 entries
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Pharmaceutical products:
None
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diosmin